Therapeutic Potential of Luteolin on Cancer

Vaccines, Год журнала: 2023, Номер 11(3), С. 554 - 554

Опубликована: Фев. 27, 2023

Cancer is a global concern, as the rate of incidence increasing each year. The challenges related to current chemotherapy drugs, such concerns toxicity, turn cancer therapeutic research discover alternative therapy strategies that are less toxic normal cells. Among those studies, use flavonoids—natural compounds produced by plants secondary metabolites for therapy—has been hot topic in treatment. Luteolin, flavonoid has present many fruits, vegetables, and herbs, identified exhibit numerous biological activities, including anti-inflammatory, antidiabetic, anticancer properties. property Luteolin extensively researched types its ability inhibit tumor growth targeting cellular processes apoptosis, angiogenesis, migration, cell cycle progression. It achieves this interacting with various signaling pathways proteins. In review, molecular targets it exerts properties, combination includes other flavonoids or chemotherapeutic nanodelivery described several types.

Язык: Английский

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Lipid Nanoparticles Optimized for Targeting and Release of Nucleic Acid

Advanced Materials, Год журнала: 2023, Номер 36(4)

Опубликована: Авг. 7, 2023

Abstract Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug delivery vehicles. LNPs prevent degradation of cargo during blood circulation. Upon entry into cell, specific components lipid can promote endosomal escape acids. These basic properties as acid carriers. As exhibit hepatic aggregation characteristics, enhancing targeting out liver is a crucial way to improve administrated in vivo. Meanwhile, loaded often considered inadequate, and therefore, much effort devoted intracellular release efficiency Here, different strategies efficiently deliver from concluded their mechanisms investigated. In addition, based on information that trials or have completed trials, issues necessary be approached translation discussed, which it hoped will shed light development LNP drugs.

Язык: Английский

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Multimodal Golden DNA Superstructures (GDSs) for Highly Efficient Photothermal Immunotherapy

ACS Nano, Год журнала: 2024, Номер 18(2), С. 1744 - 1755

Опубликована: Янв. 4, 2024

DNA-templated metallization has emerged as an efficient strategy for creating nanoscale-metal DNA hybrid structures with a desirable conformation and function. Despite the potential of DNA–metal hybrids, their use combinatory therapeutic agents rarely been examined. Herein, we present simple approach fabricating multipurpose superstructure that serves photoimmunotherapy agent. Specifically, adsorb locally concentrate Au ions onto superstructures through induced local reduction, resulting in formation nanoclusters. The mechanical optical properties these metallic nanoclusters can be rationally controlled by conformations metal ions. golden (GDSs) exhibit significant photothermal effects induce cancer cell apoptosis. When sequence-specific immunostimulatory are combined, GDSs provide synergistic effect to eradicate inhibit metastasis, demonstrating agent tumor treatment. Altogether, superstructure-templated casting system offers promising materials future biomedical applications.

Язык: Английский

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Immunotherapy: an alternative promising therapeutic approach against cancers

Molecular Biology Reports, Год журнала: 2022, Номер 49(10), С. 9903 - 9913

Опубликована: Июнь 27, 2022

Язык: Английский

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Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 2659 - 2676

Опубликована: Май 1, 2023

Abstract: Although various treatments are currently being developed, lung cancer still has a very high mortality rate. Moreover, while strategies for the diagnosis and treatment of used in clinical settings, many cases, does not respond to presents reducing survival rates. Cancer nanotechnology, also known as nanotechnology cancer, is relatively new topic study that brings together scientists from variety fields, including chemistry, biology, engineering, medicine. The use lipid-based nanocarriers aid drug distribution already had significant impact several scientific fields. Lipid-based have been demonstrated help stabilize therapeutic compounds, overcome barriers cellular tissue absorption, improve vivo delivery specific target areas. For this reason, actively researched vaccine development. This review discusses improvements achieved with nanocarriers, obstacles exist applications, current experimental applications management. Keywords: liposome, system

Язык: Английский

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Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

ChemBioChem, Год журнала: 2024, Номер 25(10)

Опубликована: Март 29, 2024

Abstract Peptides have become an indispensable tool in engineering of multifunctional nanostructure platforms for biomedical applications such as targeted drug and gene delivery, imaging biosensing. They can be covalently incorporated into a variety nanoparticles (NPs) including polymers, metallic nanoparticles, others. Using different bioconjugation techniques, peptide‐modified NPs formulated to produce therapeutical diagnostic offering high specificity, lower toxicity, biocompatibility, stimuli responsive behavior. Targeting peptides direct the specific tissues delivery due their specificity towards certain receptors. Furthermore, stimuli‐responsive features, they offer controlled release therapeutics desired sites disease. In addition, peptide‐based biosensors agents provide non‐invasive detection monitoring diseases cancer, infectious diseases, neurological disorders. this review, we covered design formulation recent NP platforms, well utilization vitro vivo targeting, sensing, applications. end, provided future outlook new peptide conjugated nanomaterials

Язык: Английский

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Cascade Carrier‐Free Nanoparticles Forming In Situ Nanovaccines for Synergistic Photothermal‐Immunotherapy of Cancer

Advanced Functional Materials, Год журнала: 2024, Номер 34(29)

Опубликована: Апрель 5, 2024

Abstract Rapid advances in nanotechnology have made it possible to combine photothermal therapy (PTT) with immunotherapy, enabling activate an situ vaccine effect. However, this effect is severely impeded by low antigen presentation level and highly suppressive tumor immune microenvironment (immune “cold” tumors). To overcome the obstacles, multifunctional carrier‐free nanoparticles (FCDP‐NPs) assembled from Fe 2+ , toll‐like receptor 9 agonist (CpG), cationic lipid (DOTAP) agent polydopamine are developed. After intratumoral injection, FCDP‐NPs carrying positive charge exposed under laser irradiation, which can capture tumor‐associated antigens (TAAs) generated upon post‐PTT form nanovaccines (FCD‐NPs@TAAs). The further promote cross‐presentation of TAAs, stimulate adaptive responses, shape “hot” tumors. As a result, improve survival rates elicit durable memory that remarkedly prevents metastasis, illustrating useful platform for PTT synergized immunotherapy.

Язык: Английский

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Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 7, 2025

This paper explored the novel approach of targeting cyclic guanosine monophosphate (GMP)-adenosine (AMP) synthase-stimulator interferon genes (cGAS-STING) pathway for treatment osteosarcoma (OS). Osteosarcoma is a common malignancy in adolescents. Most patients die from lung metastasis. It reviewed epidemiology and pathological characteristics OS, highlighting its highly malignant nature tendency pulmonary metastasis, underscoring importance identifying new therapeutic targets. The cGAS-STING was closely associated with biological behaviors OS cells, suggesting that this could be promising strategy. Currently, research on role has been limited, underlying mechanisms remain unclear. Therefore, further investigation into exploration strategies based are great significance developing more effective treatments OS. offered fresh perspective providing hope options by pathway.

Язык: Английский

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Recent Advances in Cancer Immunotherapy Delivery Modalities

Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 504 - 504

Опубликована: Фев. 2, 2023

Immunotherapy is crucial in fighting cancer and achieving successful remission. Many novel strategies have recently developed, but there are still some obstacles to overcome before we can effectively attack the cells decimate environment by inducing a cascade of immune responses. To successfully demonstrate antitumor activity, must be delivered exposed system. Such cutting-edge technology necessitates meticulously designed delivery methods with no loss or superior homing onto environments, as well high therapeutic efficacy fewer adverse events. In this paper, discuss recent advances immunotherapy techniques, their future prospects.

Язык: Английский

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Immunotherapy: cancer immunotherapy and its combination with nanomaterials and other therapies

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(36), С. 8586 - 8604

Опубликована: Янв. 1, 2023

Immunotherapy is a new type of tumor treatment. In this review, the main focus on an overview research progress immunotherapy in cancer treatment and combined application with other therapeutic approaches.

Язык: Английский

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