Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Дек. 3, 2022
Abstract
Background
The
prevalence
of
viral
infectious
diseases
has
become
a
serious
threat
to
public
safety,
economic
and
social
development.
Vaccines
have
been
served
as
the
most
effective
platform
prevent
virus
transmission
via
activation
host
immune
responses,
while
low
immunogenicity
or
high
cost
production,
storage,
transport
limit
their
clinical
application.
Therefore,
there
is
need
develop
promising
strategy
improve
safety
vaccines.
Methods
We
developed
splenic-targeting
biomimetic
nanovaccine
(NV)
that
can
boost
protective
humoral
cellular
immunity
against
african
swine
fever
(ASFV)
infection.
universal
PLGA
nanoparticles
(CMR-PLGA/p54
NPs)
coated
with
mannose
CpG
(TLR9
agonist)
co-modified
red
blood
cell
(RBC)
membrane
were
prepared,
which
comprised
antigen
(p54)
be
versatile
for
elevating
immunity.
Results
CMR-PLGA/p54
NVs
could
effectively
uptaken
by
BMDC
promoted
maturation
in
vitro.
After
subcutaneous
immunization,
delivered
splenic
dendritic
cells
(DCs)
due
homing
ability
RBC
DC
targeting
capacity
mannose,
presentation
DCs
maturation,
further
elicited
higher
levels
cytokines
secretion
specific
IgG
titers,
CD4
+
CD8
T
B
maturation.
Moreover,
demonstrated
notable
during
immunization
period.
Conclusions
This
study
demonstrates
potential
CMR-PLGA
NPs
vaccine
delivery
carriers
promote
it
provides
safe
vaccines
diseases.
Chemical & Biomedical Imaging,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Aggregation-induced
emission
(AIE)
materials,
due
to
their
unique
ability
significantly
enhance
optical
in
aggregated
states,
have
demonstrated
vast
potential
immunology,
particularly
early
disease
diagnosis
and
immunotherapy.
AIE
materials
can
serve
as
highly
efficient
fluorescent
probes
for
biomarker
detection,
providing
critical
insights
diagnosis.
Additionally,
they
act
cancer
vaccines,
enhancing
the
effectiveness
of
immunotherapy
through
photodynamic
therapy,
photothermal
or
activation
immune
cells.
This
review
highlights
applications
focusing
on
recent
advancements
diagnostics
while
also
discussing
challenges
face
directions
future
development.
Heliyon,
Год журнала:
2024,
Номер
10(5), С. e27234 - e27234
Опубликована: Март 1, 2024
Cellular
immunotherapy
is
a
crucial
aspect
of
current
tumor
immunotherapy,
though
it
presents
several
challenges
such
as
immune
cell
dysfunction,
limited
recognition
neoantigens,
and
inadequate
lymphocyte
infiltration
into
the
microenvironment.
This
study
proposes
novel
approach
utilizing
combination
dendritic
(DC)-based
cellular
photothermal
nanoadjuvant
black
phosphorus
(BP)
nanoparticles
to
overcome
these
challenges.
A
new
platform
called
PLGA@BP-R848,
which
consists
modifying
poly-(lactic-co-glycolic
acid)
(PLGA)
onto
BP
nanosheets
loading
adjuvant
R848.
The
PLGA@BP-R848
demonstrated
exceptional
drug
delivery
release
capabilities,
well
effect,
biocompatibility,
ability
activate
mitochondrial
apoptotic
pathway
Blc-2-Bax-Cytochrome
c-caspase-3
inhibit
PI3K-AKT-mTOR
signaling
pathway.
In
hepatocellular
carcinoma
mouse
model,
binding
cells
primed
with
GPC3
peptides,
successfully
induced
systemic
anti-tumor
response.
bolster
tumors
induce
cancer
apoptosis.
synergistic
therapy
involving
effectively
suppressed
growth,
facilitated
formation
tertiary
lymphatic
structures
(TLS)
in
tumors.
using
nanoadjuvants
advance
antitumor
effect
DCs
therapy.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Дек. 3, 2022
Abstract
Background
The
prevalence
of
viral
infectious
diseases
has
become
a
serious
threat
to
public
safety,
economic
and
social
development.
Vaccines
have
been
served
as
the
most
effective
platform
prevent
virus
transmission
via
activation
host
immune
responses,
while
low
immunogenicity
or
high
cost
production,
storage,
transport
limit
their
clinical
application.
Therefore,
there
is
need
develop
promising
strategy
improve
safety
vaccines.
Methods
We
developed
splenic-targeting
biomimetic
nanovaccine
(NV)
that
can
boost
protective
humoral
cellular
immunity
against
african
swine
fever
(ASFV)
infection.
universal
PLGA
nanoparticles
(CMR-PLGA/p54
NPs)
coated
with
mannose
CpG
(TLR9
agonist)
co-modified
red
blood
cell
(RBC)
membrane
were
prepared,
which
comprised
antigen
(p54)
be
versatile
for
elevating
immunity.
Results
CMR-PLGA/p54
NVs
could
effectively
uptaken
by
BMDC
promoted
maturation
in
vitro.
After
subcutaneous
immunization,
delivered
splenic
dendritic
cells
(DCs)
due
homing
ability
RBC
DC
targeting
capacity
mannose,
presentation
DCs
maturation,
further
elicited
higher
levels
cytokines
secretion
specific
IgG
titers,
CD4
+
CD8
T
B
maturation.
Moreover,
demonstrated
notable
during
immunization
period.
Conclusions
This
study
demonstrates
potential
CMR-PLGA
NPs
vaccine
delivery
carriers
promote
it
provides
safe
vaccines
diseases.
