Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Advanced Science, Год журнала: 2023, Номер 10(22)

Опубликована: Май 31, 2023

Abstract Cancer immunotherapies have improved human health, and one among the important technologies for cancer immunotherapy is vaccine. Antigens are most components in vaccines. Generally, antigens vaccines can be divided into two categories: pre‐defined unidentified antigens. Although, loaded with predefined commonly used, vaccine mixed antigens, especially whole cells or cell lysates, a very promising approach, such obviate some limitations Their advantages include, but not limited to, inclusion of pan‐spectra (all kinds of) inducing pan‐clones specific T cells, overcoming heterogeneity cells. In this review, recent advances based on whole‐tumor either summarized. terms focus applying water‐soluble lysates as Recently, utilizing has become feasible. Considering that pre‐determined antigen‐based (mainly peptide‐based mRNA‐based) various limitations, developing alternative.

Язык: Английский

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Lymphoid organ-targeted nanomaterials for immunomodulation of cancer, inflammation, and beyond

Chemical Society Reviews, Год журнала: 2024, Номер 53(15), С. 7657 - 7680

Опубликована: Янв. 1, 2024

Nanomaterials exhibit significant potential for stimulating immune responses, offering both local and systemic modulation across a variety of diseases. The lymphoid organs, such as the spleen lymph nodes, are home to various cells, including monocytes dendritic which contribute progression prevention/treatment Consequently, many nanomaterial formulations being rationally designed target these organs engage with specific cell types, thereby inducing therapeutic protective effects. In this review, we explore crucial cellular interactions processes involved in regulation highlight innovative nano-based immunomodulatory approaches. We outline essential considerations design an emphasis on their impact biological interactions, targeting capabilities, treatment efficacy. Through selected examples, illustrate strategic therapeutically active nanomaterials subsequent immunomodulation infection resistance, inflammation suppression, self-antigen tolerance, cancer immunotherapy. Additionally, address current challenges, discuss emerging topics, share our outlook future developments field.

Язык: Английский

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Application of biomimetic nanovaccines in cancer immunotherapy: A useful strategy to help combat immunotherapy resistance

Drug Resistance Updates, Год журнала: 2024, Номер 75, С. 101098 - 101098

Опубликована: Июнь 1, 2024

Язык: Английский

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A Spleen‐Targeted Tolerogenic mRNA‐LNPs Vaccine for the Treatment of Experimental Asthma

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Lipid nanoparticles (LNPs)-based mRNA vaccines have witnessed their great advantages in the fight against infectious diseases. However, pro-inflammatory properties of mRNA-LNPs may hinder induction antigen-specific tolerogenic immune responses. Here, it is demonstrated that stearic acid-doped LNPs co-loaded with nucleoside-modified and celastrol selectively target spleen, convert adjuvanticity promote a rather than immunogenic DCs phenotype. Furthermore, vaccine also invokes generation regulatory T cells (Tregs) spleen migration induced Tregs to lung. In mouse model allergic asthma, immunization significantly alleviated symptom induction, reducing eosinophilic granulocyte accumulation mucus secretion. conclusion, this spleen-targeted platform induces responses, offering promise for development therapeutics asthma other conditions requiring tolerance modulation.

Язык: Английский

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Practical approach to development of GS-445124-loaded PLGA nanoparticles for the long-term treatment of feline infectious peritonitis caused by feline coronavirus infection

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125468 - 125468

Опубликована: Март 1, 2025

Язык: Английский

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Recent Advances of Emerging Spleen‐Targeting Nanovaccines for Immunotherapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(23)

Опубликована: Июнь 8, 2023

Abstract Vaccines provide a powerful tool to modulate the immune system for human disease prevention and treatment. Classical vaccines mainly initiate responses in lymph nodes (LNs) after subcutaneous injection. However, some suffer from inefficient delivery of antigens LNs, undesired inflammation, slow induction when encountering rapid proliferation tumors. Alternatively, spleen, as largest secondary lymphoid organ with high density antigen‐presenting cells (APCs) lymphocytes, acts an emerging target vaccinations body. Upon intravenous administration, rationally designed spleen‐targeting nanovaccines can be internalized by APCs spleen induce selective antigen presentation T B their specific sub‐regions, thereby rapidly boosting durable cellular humoral immunity. Herein, recent advances immunotherapy based on anatomical architectures functional zones well limitations perspectives clinical applications are systematically summarized. The aim is emphasize design innovative enhanced intractable diseases future.

Язык: Английский

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Inhalable hybrid nanovaccines with virus-biomimetic structure boost protective immune responses against SARS-CoV-2 variants

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Фев. 27, 2024

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with different antigenic variants, has posed a significant threat to public health. It is urgent develop inhalable vaccines, instead of injectable elicit mucosal immunity against viral infections. Methods We reported an hybrid nanovaccine (NV RBD -MLipo) boost protective SARS-CoV-2 infection. Nanovesicles derived from genetically engineered 293T cells expressing ) were fused pulmonary surfactant (PS)-biomimetic liposomes containing MPLA (MLipo) yield NV -MLipo, which possessed virus-biomimetic structure, inherited expression and versatile properties. Results In contrast subcutaneous vaccination, via could efficiently enter the alveolar macrophages (AMs) AMs activation through MPLA-activated TLR4/NF-κB signaling pathway. Moreover, -MLipo induced T B activation, high level RBD-specific IgG secretory IgA (sIgA), thus elevating systemic immune responses, while reducing side effects. also demonstrated broad-spectrum neutralization activity (WT, Delta, Omicron) pseudovirus, protected immunized mice WT pseudovirus Conclusions This as effective safe nanovaccine, holds huge potential provoke robust immunity, might be promising vaccine candidate combat infectious diseases, including COVID-19 influenza.

Язык: Английский

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Dimethyl-Dioctadecyl-Ammonium Bromide/Poly(lactic acid) Nanoadjuvant Enhances the Immunity and Cross-Protection of an NM2e-Based Universal Influenza Vaccine

ACS Nano, Год журнала: 2024, Номер 18(20), С. 12905 - 12916

Опубликована: Май 9, 2024

For most frequent respiratory viruses, there is an urgent need for a universal influenza vaccine to provide cross-protection against intra- and heterosubtypes. We previously developed Escherichia coli fusion protein expressed extracellular domain of matrix 2 (M2e) nucleoprotein, named NM2e, then combined it with aluminum adjuvant, forming vaccine. Although NM2e has demonstrated protective effect the virus in mice some extent, further improvement still needed induction immune responses ensuring adequate influenza. Herein, we fabricated cationic solid lipid nanoadjuvant using poly(lactic acid) (PLA) dimethyl-dioctadecyl-ammonium bromide (DDAB) loaded generate NM2e@DDAB/PLA nanovaccine (Nv). In vitro experiments suggested that bone marrow-derived dendritic cells incubated Nv exhibited ∼4-fold higher antigen (Ag) uptake than at 16 h along efficient activation by Nv. vivo revealed Ag group stayed lymph nodes (LNs) more 14 days after initial immunization DCs LNs were evidently activated matured. Furthermore, primed T B robust humoral cellular immunization. It also induced ratio IgG2a/IgG1 considerable extent. Moreover, quickly restored body weight improved survival homo- heterosubtype challenged mice, efficiency was over 90%. Collectively, our study could offer notable protection challenges, offering potential development

Язык: Английский

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Encapsulin nanoparticle-conjugated p54 protein boosts immune responses against African swine fever virus

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143912 - 143912

Опубликована: Май 1, 2025

Язык: Английский

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Animal vaccine revolution: Nanoparticle adjuvants open the future of vaccinology

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113827 - 113827

Опубликована: Май 1, 2025

Язык: Английский

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