Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machine learning study DOI Creative Commons
Lele Ye,

Chunhao Long,

Binbing Xu

и другие.

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Янв. 8, 2025

Abstract Background Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, programmed cell death (PCD) increasingly recognized as potential target in cancer therapy prognosis. However, PCD-based predictive model for serous ovarian carcinoma (SOC) lacking. In present study, we to establish index (CDI)–based using PCD-related genes. Methods We included 1254 genes from 12 PCD patterns our analysis. Differentially expressed (DEGs) Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) were screened. Subsequently, 14 PCD-gene-based CDI model. Genomics, single-cell transcriptomes, bulk spatial clinical information TCGA-OV, GSE26193, GSE63885, GSE140082 collected analyzed verify prediction Results The was an independent prognostic risk factor patients with SOC. Patients SOC high had lower survival rates poorer prognoses than those low CDI. Specific parameters combined nomogram that accurately assessed patient survival. used PCD-genes observe differences between groups. results showed immunosuppression hardly benefited immunotherapy; therefore, trametinib_1372 BMS-754807 may be therapeutic agents these patients. Conclusions CDI-based model, which established genes, predicted tumor microenvironment, immunotherapy response, drug sensitivity Thus this help improve diagnostic efficacy PPPM.

Язык: Английский

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research DOI Creative Commons

Xuhui Tong,

Rong Tang,

Mingming Xiao

и другие.

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Дек. 8, 2022

Abstract Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various activities, including clearance aberrant cells. Thus, RCD pathways represented by apoptosis have increased in importance as a target development cancer medications recent years. However, because tumor show avoidance apoptosis, which causes treatment resistance recurrence, numerous studies been devoted alternative mortality processes, namely necroptosis, pyroptosis, ferroptosis, cuproptosis; these modalities extensively studied shown be crucial therapy effectiveness. Furthermore, evidence suggests that undergoing may alter immunogenicity microenvironment (TME) some extent, rendering it more suitable inhibiting progression metastasis. In addition, other components TME undergo abovementioned forms induce immune attacks on cells, resulting enhanced antitumor responses. Hence, this review discusses molecular processes features cuproptosis effects novel proliferation Importantly, introduces complex affect biology. It also summarizes potential agents nanoparticles or inhibit their therapeutic based from vivo vitro reports clinical trials inducers evaluated treatments patients. Lastly, we summarized impact modulating drug advantages adding modulators over conventional treatments.

Язык: Английский

Процитировано

500
Unraveling tumor microenvironment of small-cell lung cancer: Implications for immunotherapy DOI
Tian Li,

Tianyun Qiao

Seminars in Cancer Biology, Год журнала: 2022, Номер 86, С. 117 - 125

Опубликована: Сен. 29, 2022

Язык: Английский

Процитировано

90
PANoptosis: Mechanisms, biology, and role in disease DOI Open Access

Xu Sun,

Yanpeng Yang,

Xiaona Meng

и другие.

Immunological Reviews, Год журнала: 2023, Номер 321(1), С. 246 - 262

Опубликована: Окт. 12, 2023

Summary Cell death can be executed through distinct subroutines. PANoptosis is a unique inflammatory cell modality involving the interactions between pyroptosis, apoptosis, and necroptosis, which mediated by multifaceted PANoptosome complexes assembled via integrating components from other modalities. There growing interest in process function of PANoptosis. Accumulating evidence suggests that occurs under diverse stimuli, for example, viral or bacterial infection, cytokine storm, cancer. Given impact across disease spectrum, this review briefly describes relationships highlights key molecules formation activation, outlines roles diseases together with potential therapeutic targeting. We also discuss important concepts pressing issues future research. Improved understanding its mechanisms crucial identifying novel targets strategies.

Язык: Английский

Процитировано

72
Small cell lung cancer: Novel treatments beyond immunotherapy DOI Creative Commons

Job-Joris Meijer,

Alessandro Leonetti, Giulia Airò

и другие.

Seminars in Cancer Biology, Год журнала: 2022, Номер 86, С. 376 - 385

Опубликована: Май 11, 2022

Small cell lung cancer (SCLC) arises in peribronchial locations and infiltrates the bronchial submucosa, including about 15% of cases. Despite decades research, prognosis for SCLC patients remains poor because this tumor is characterized by an exceptionally high proliferative rate, strong tendency early widespread metastasis acquired chemoresistance. Omics profiling revealed that harbor extensive chromosomal rearrangements a very mutation burden. This led to development immune-checkpoint inhibitors as single agents or combination with chemotherapy, which however resulted prolonged benefit only small subset patients. Thus, present review discusses rationale limitations immunotherapeutic approaches, presenting current biological understanding aberrant signaling pathways might be exploited new potential treatments. In particular, targeting DNA damage repair, cycle checkpoint, apoptosis showed several promising results different preclinical models. Epigenetic alterations, gene amplifications mutations can act biomarkers context. Future research improved clinical outcome will depend on integration between these omics pharmacological studies translational order identify specific predictive hopefully validated using trials biomarker-selected targeted

Язык: Английский

Процитировано

71
Immuno-photodynamic Therapy (IPDT): Organic Photosensitizers and Their Application in Cancer Ablation DOI Creative Commons
Lu Yang, Wen Sun, Jianjun Du

и другие.

JACS Au, Год журнала: 2023, Номер 3(3), С. 682 - 699

Опубликована: Фев. 14, 2023

Photosensitizer-based photodynamic therapy (PDT) has been considered as a promising modality for fighting diverse types of cancers. PDT directly inhibits local tumors by minimally invasive strategy, but it seems to be incapable achieving complete eradication and fails prevent metastasis recurrence. Recently, increasing events proved that was associated with immunotherapy triggering immunogenic cell death (ICD). Upon specific wavelength light irradiation, the photosensitizers will turn surrounding oxygen molecules into cytotoxic reactive species (ROS) killing cancer cells. Simultaneously, dying tumor cells release tumor-associated antigens, which could improve immunogenicity activate immune However, progressively enhanced immunity is typically limited intrinsic immunosuppressive microenvironment (TME). To overcome this obstacle, immuno-photodynamic (IPDT) come one most beneficial strategies, takes advantage stimulate response unite inducing immune-OFF immune-ON ones, achieve systemic In Perspective, we provide review recent advances in organic photosensitizer-based IPDT. The general process responses triggered (PSs) how enhance antitumor pathway modifying chemical structure or conjugating targeting component discussed. addition, future perspectives challenges IPDT strategies are also We hope Perspective inspire more innovative ideas executable developments war against cancer.

Язык: Английский

Процитировано

62
Application of artificial intelligence for improving early detection and prediction of therapeutic outcomes for gastric cancer in the era of precision oncology DOI
Zhe Wang, Yang Liu, Xing Niu

и другие.

Seminars in Cancer Biology, Год журнала: 2023, Номер 93, С. 83 - 96

Опубликована: Апрель 27, 2023

Язык: Английский

Процитировано

46
High Immunogenic Cuproptosis Evoked by In Situ Sulfidation‐Activated Pyroptosis for Tumor‐Targeted Immunotherapy of Colorectal Cancer DOI Creative Commons

Wentao Xiao,

Kuiming Qu,

Wei Zhang

и другие.

Small Science, Год журнала: 2024, Номер 4(3)

Опубликована: Янв. 17, 2024

Despite the great potential of cuproptosis in tumor therapy, current cuproptosis‐based therapy still suffers from compromised efficiency immune activation. Pyroptosis, a proinflammatory cell death modality, provides good opportunity to induce immunogenic (ICD) and promote systemic response. However, synergistic pyroptosis has not been fully explored. Herein, it is discovered that Cu(II)‐based metal–organic framework (MOF) nanoparticles (NPs) can synergistically evoke ICD for high‐efficiency tumor‐targeted immunotherapy. Although MOF‐199 widely used immunogenicity unclear. Pluronic F127‐modified NPs ( F127 NPs) show dual‐responsiveness glutathione (GSH) hydrogen sulfide (H 2 S). Once entering cancer cells, dissociate GSH‐enriched microenvironment (TME) release copper ion copper‐overload‐mediated cuproptosis. Meanwhile, transform Cu 2− x S by situ sulfidation under H S‐enriched colorectal (CRC) TME. Under photothermal chemodynamic (PTT/CDT) NPs, caspase‐3 activated gasdermin E (GSDME)‐related triggered. The have proved superior antitumor immunity effect both vitro vivo experiments. This work new strategy achieve immunotherapy with high simple NPs.

Язык: Английский

Процитировано

18
Reshaping the immune microenvironment and reversing immunosenescence by natural products: prospects for immunotherapy in gastric cancer DOI
Zhipeng Cao, Zhilin Wang, Yang Li

и другие.

Seminars in Cancer Biology, Год журнала: 2025, Номер 110, С. 1 - 16

Опубликована: Фев. 8, 2025

Язык: Английский

Процитировано

2
DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma DOI

Zhongyan Zhang,

Qi Zhou, Zhenchong Li

и другие.

Drug Resistance Updates, Год журнала: 2025, Номер 81, С. 101224 - 101224

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

2
Targeting ferroptosis as a vulnerability in pulmonary diseases DOI Creative Commons
Li Yang, Limian Cao, Xiaoju Zhang

и другие.

Cell Death and Disease, Год журнала: 2022, Номер 13(7)

Опубликована: Июль 26, 2022

Abstract Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative phospholipids (PLs). The polyunsaturated fatty acids-containing (PUFA-PLs) are highly susceptible to lipid peroxidation under stress. Numerous pulmonary diseases occurrences and degenerative pathologies driven ferroptosis. This review discusses the role of ferroptosis in pathogenesis including asthma, lung injury, cancer, fibrotic diseases, infection. Additionally, it proposed that targeting a potential treatment for particularly drug-resistant cancer or antibiotic-resistant infection, reduces treatment-related adverse events.

Язык: Английский

Процитировано

60