Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machine learning study DOI Creative Commons
Lele Ye,

Chunhao Long,

Binbing Xu

и другие.

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Янв. 8, 2025

Abstract Background Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, programmed cell death (PCD) increasingly recognized as potential target in cancer therapy prognosis. However, PCD-based predictive model for serous ovarian carcinoma (SOC) lacking. In present study, we to establish index (CDI)–based using PCD-related genes. Methods We included 1254 genes from 12 PCD patterns our analysis. Differentially expressed (DEGs) Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) were screened. Subsequently, 14 PCD-gene-based CDI model. Genomics, single-cell transcriptomes, bulk spatial clinical information TCGA-OV, GSE26193, GSE63885, GSE140082 collected analyzed verify prediction Results The was an independent prognostic risk factor patients with SOC. Patients SOC high had lower survival rates poorer prognoses than those low CDI. Specific parameters combined nomogram that accurately assessed patient survival. used PCD-genes observe differences between groups. results showed immunosuppression hardly benefited immunotherapy; therefore, trametinib_1372 BMS-754807 may be therapeutic agents these patients. Conclusions CDI-based model, which established genes, predicted tumor microenvironment, immunotherapy response, drug sensitivity Thus this help improve diagnostic efficacy PPPM.

Язык: Английский

Enhancing cancer immunotherapy with photodynamic therapy and nanoparticle: making tumor microenvironment hotter to make immunotherapeutic work better DOI Creative Commons

Jayalakshmi Thiruppathi,

Veena Vijayan, In‐Kyu Park

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 5, 2024

Cancer immunotherapy has made tremendous advancements in treating various malignancies. The biggest hurdle to successful would be the immunosuppressive tumor microenvironment (TME) and low immunogenicity of cancer cells. To make successful, ‘cold’ TME must converted ‘hot’ immunostimulatory status activate residual host immune responses. this end, equilibrium should broken, immunogenic cell death ought induced stimulate tumor-killing cells appropriately. Photodynamic therapy (PDT) is an efficient way inducing (ICD) disrupting immune-restrictive tissues. PDT trigger a chain reaction that have ICD-induced antigens presented In principle, strategic combination synergize enhance therapeutic outcomes many intractable tumors. Novel technologies employing nanocarriers were developed deliver photosensitizers immunotherapeutic efficiently. New-generation nanomedicines been for recent years, which will accelerate clinical applications.

Язык: Английский

Процитировано

12
Copper(II)-Based Nano-Regulator Correlates Cuproptosis Burst and Sequential Immunogenic Cell Death for Synergistic Cancer Immunotherapy DOI Creative Commons
Luo Yingli, Xianyu Luo, Yi Ru

и другие.

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Immunogenic cell death (ICD) of tumor cells serves as a crucial initial signal in the activation anti-tumor immune responses, holding marked promise field immunotherapy. However, low immunogenicity tumors pose challenges achieving complete induction ICD, thereby limiting response rates immunotherapy clinical patients. The emergence cuproptosis new form regulated has presented promising strategy for enhanced immunogenic tumors. To trigger cuproptosis, copper-ionophore elesclomol (ES) had to be employed copper-transporting-mediated process. Herein, we proposed copper(II)-based metal-organic framework nanoplatform (Cu-MOF) facilitate cooperative delivery encapsulated ES and copper (ES-Cu-MOF) induce burst enhance ICD fibrosarcoma. Our results showed that ES-Cu-MOF nano-regulator could effectively release Cu 2+ intracellular environment, resulting elevated mitochondrial ROS generation initiated cells. Furthermore, sequential ICDs were significantly triggered via activate response. inhibition experiment indicated obviously accumulated site, inducing dendritic activation. This enabled an increased infiltration cytotoxic CD8 + T consequently antitumor responses successfully suppressing fibrosarcoma growth. Thus, offered approach cuproptosis-stimulated cancer

Язык: Английский

Процитировано

10
T cell exhaustion and senescence for ovarian cancer immunotherapy DOI
Jiao Zhao,

Zhongmiao Wang,

Yingying Tian

и другие.

Seminars in Cancer Biology, Год журнала: 2024, Номер 104-105, С. 1 - 15

Опубликована: Июль 18, 2024

Язык: Английский

Процитировано

10
Small Cell Lung Cancer—An Update on Chemotherapy Resistance DOI
Ying Qian,

Ruiyun Fan,

Yili Shen

и другие.

Current Treatment Options in Oncology, Год журнала: 2024, Номер 25(8), С. 1112 - 1123

Опубликована: Июль 27, 2024

Язык: Английский

Процитировано

9
Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machine learning study DOI Creative Commons
Lele Ye,

Chunhao Long,

Binbing Xu

и другие.

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Янв. 8, 2025

Abstract Background Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, programmed cell death (PCD) increasingly recognized as potential target in cancer therapy prognosis. However, PCD-based predictive model for serous ovarian carcinoma (SOC) lacking. In present study, we to establish index (CDI)–based using PCD-related genes. Methods We included 1254 genes from 12 PCD patterns our analysis. Differentially expressed (DEGs) Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) were screened. Subsequently, 14 PCD-gene-based CDI model. Genomics, single-cell transcriptomes, bulk spatial clinical information TCGA-OV, GSE26193, GSE63885, GSE140082 collected analyzed verify prediction Results The was an independent prognostic risk factor patients with SOC. Patients SOC high had lower survival rates poorer prognoses than those low CDI. Specific parameters combined nomogram that accurately assessed patient survival. used PCD-genes observe differences between groups. results showed immunosuppression hardly benefited immunotherapy; therefore, trametinib_1372 BMS-754807 may be therapeutic agents these patients. Conclusions CDI-based model, which established genes, predicted tumor microenvironment, immunotherapy response, drug sensitivity Thus this help improve diagnostic efficacy PPPM.

Язык: Английский

Процитировано

1