Copper(II)-Based Nano-Regulator Correlates Cuproptosis Burst and Sequential Immunogenic Cell Death for Synergistic Cancer Immunotherapy

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

Immunogenic cell death (ICD) of tumor cells serves as a crucial initial signal in the activation anti-tumor immune responses, holding marked promise field immunotherapy. However, low immunogenicity tumors pose challenges achieving complete induction ICD, thereby limiting response rates immunotherapy clinical patients. The emergence cuproptosis new form regulated has presented promising strategy for enhanced immunogenic tumors. To trigger cuproptosis, copper-ionophore elesclomol (ES) had to be employed copper-transporting-mediated process. Herein, we proposed copper(II)-based metal-organic framework nanoplatform (Cu-MOF) facilitate cooperative delivery encapsulated ES and copper (ES-Cu-MOF) induce burst enhance ICD fibrosarcoma. Our results showed that ES-Cu-MOF nano-regulator could effectively release Cu 2+ intracellular environment, resulting elevated mitochondrial ROS generation initiated cells. Furthermore, sequential ICDs were significantly triggered via activate response. inhibition experiment indicated obviously accumulated site, inducing dendritic activation. This enabled an increased infiltration cytotoxic CD8 + T consequently antitumor responses successfully suppressing fibrosarcoma growth. Thus, offered approach cuproptosis-stimulated cancer

Language: Английский

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T cell exhaustion and senescence for ovarian cancer immunotherapy

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 104-105, P. 1 - 15

Published: July 18, 2024

Language: Английский

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Utilization of aggregation‐induced emission materials in urinary system diseases

Aggregate, Journal Year: 2024, Volume and Issue: 5(5)

Published: May 10, 2024

Abstract With the development of aggregation‐induced emission (AIE) materials, drawbacks conventional fluorescence materials subjected to aggregation‐caused quenching (ACQ) have been resolved. This has allowed for improvement novel AIE fluorescent that exhibit enhanced photostability, a higher signal‐to‐noise ratio, and better imaging quality. Meanwhile, phototherapeutic effect garnered widespread attention in realm tumor treatment. The distinct physiological anatomical characteristics urinary system make it suitable use materials. Additionally, AIE‐based phototherapy provides superior solution deal with weaknesses treatments urologic neoplasms. In this review, scientific advancement on diseases since emergence concept is reviewed detail. review highlights promise biomarkers detection, (FLI) vivo vitro, phototherapy, synergistic therapy from both diagnostic therapeutic viewpoints. It firmly believed hold immense untapped potential diagnosis treatment disease, as well all human body.

Language: Английский

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Small Cell Lung Cancer—An Update on Chemotherapy Resistance

Current Treatment Options in Oncology, Journal Year: 2024, Volume and Issue: 25(8), P. 1112 - 1123

Published: July 27, 2024

Language: Английский

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DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 81, P. 101224 - 101224

Published: Feb. 28, 2025

Language: Английский

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