Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Май 2, 2024
Abstract
Long
non-coding
RNAs
(lncRNAs)
are
transcripts
that
contain
more
than
200
nucleotides.
Despite
their
inability
to
code
proteins,
multiple
studies
have
identified
important
role
in
human
cancer
through
different
mechanisms.
LncRNA
lysyl
oxidase
like
1
antisense
RNA
(LOXL1-AS1),
a
newly
discovered
lncRNA
located
on
chromosome
15q24.1,
has
recently
been
shown
be
involved
the
occurrence
and
progression
of
various
malignancies,
such
as
colorectal
cancer,
gastric
hepatocellular
carcinoma,
prostate
non-small
cell
lung
ovarian
cervical
breast
glioma,
thymic
pancreatic
carcinoma.
LOXL1-AS1
acts
competitive
endogenous
(ceRNA)
via
sponging
miRNAs,
including
miR-374b-5p,
miR-21,
miR-423-5p,
miR-589-5p,
miR-28-5p,
miR-324-3p,
miR-708-5p,
miR-143-3p,
miR-18b-5p,
miR-761,
miR-525-5p,
miR-541-3p,
miR-let-7a-5p,
miR-3128,
miR-3614-5p,
miR-377-3p
miR-1224-5p
promote
tumor
proliferation,
invasion,
migration,
apoptosis,
cycle,
epithelial–mesenchymal
transformation
(EMT).
In
addition,
is
regulation
P13K/AKT
MAPK
signaling
pathways.
This
article
reviews
current
understanding
biological
function
clinical
significance
cancers.
These
findings
suggest
may
both
reliable
biomarker
potential
therapeutic
target
for
Experimental & Molecular Medicine,
Год журнала:
2024,
Номер
56(9), С. 1909 - 1920
Опубликована: Сен. 2, 2024
Functional
variations
in
coding
and
noncoding
RNAs
are
crucial
tumorigenesis,
with
cancer-specific
alterations
often
resulting
from
chemical
modifications
posttranscriptional
processes
mediated
by
enzymes.
These
RNA
have
been
linked
to
tumor
cell
proliferation,
growth,
metastasis,
drug
resistance
valuable
for
identifying
diagnostic
or
prognostic
cancer
biomarkers.
The
diversity
of
modifications,
such
as
splicing,
polyadenylation,
methylation,
editing,
is
particularly
significant
due
their
prevalence
impact
on
progression.
Additionally,
other
including
acetylation,
circularization,
miRNA
isomerization,
pseudouridination,
recognized
key
contributors
development.
Understanding
the
mechanisms
underlying
these
can
enhance
our
knowledge
biology
facilitate
development
innovative
therapeutic
strategies.
Targeting
regulatory
enzymes
may
pave
way
novel
RNA-based
therapies,
enabling
tailored
interventions
specific
subtypes.
This
review
provides
a
comprehensive
overview
roles
various
progression
highlights
recent
advancements
applications.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
163, С. 114756 - 114756
Опубликована: Апрель 25, 2023
Long
non-coding
RNAs
(lncRNAs)
are
commonly
known
for
their
important
characters
in
cancer
progression.
LncRNA
MAFG-antisense
1
(AS1)
(MAFG-AS1)
has
been
discovered
as
a
novel
oncogenic
lncRNA
several
years.
Accumulating
data
have
demonstrated
abnormal
overexpression
of
MAFG-AS1
various
human
cancers,
including
breast,
bladder,
liver,
gastric,
and
lung.
Importantly,
through
regulating
microRNAs
cell
signaling
pathways,
to
exhibit
biological
effects,
proliferation,
metastasis,
epithelial-mesenchymal
transition
(EMT).
Meanwhile,
is
closely
linked
with
histological
grade,
TNM
stage,
extensive
depth
invasion,
poor
OS,
lymph
node
metastasis
(LNM).
In
the
present
review,
authors
summarized
previous
studies
on
properties,
molecular
mechanisms,
clinicopathological
cancers.
summary,
promising
prognostic
marker
potential
therapeutic
target
treatment.
Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Дек. 18, 2023
Abstract
RNA
methylation
modification
plays
a
crucial
role
as
an
epigenetic
regulator
in
the
oncogenesis
of
hepatocellular
carcinoma
(HCC).
Numerous
studies
have
investigated
molecular
mechanisms
underlying
protein-coding
RNAs
progression
HCC.
Beyond
their
impact
on
mRNA,
modifications
also
influence
biological
functions
non-coding
(ncRNAs).
Here,
we
present
advanced
and
comprehensive
overview
interplay
between
ncRNAs
HCC,
with
specific
focus
potential
implications
for
tumor
immune
microenvironment.
Moreover,
summarize
promising
therapeutic
targets
HCC
based
methylation-related
proteins.
In
future,
more
profound
investigation
is
warranted
to
elucidate
effects
ncRNA
pathogenesis
devise
valuable
intervention
strategies.
Modern Rheumatology,
Год журнала:
2024,
Номер
34(6), С. 1265 - 1276
Опубликована: Март 5, 2024
Osteoarthritis
(OA)
is
the
most
common
chronic
joint
degenerative
disease.
Herein,
we
investigated
long
non-coding
RNA
Opa-interacting
protein
5-antisense
transcript
1's
(OIP5-AS1)
in
regulating
mitophagy
during
OA.
Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Май 2, 2024
Abstract
Long
non-coding
RNAs
(lncRNAs)
are
transcripts
that
contain
more
than
200
nucleotides.
Despite
their
inability
to
code
proteins,
multiple
studies
have
identified
important
role
in
human
cancer
through
different
mechanisms.
LncRNA
lysyl
oxidase
like
1
antisense
RNA
(LOXL1-AS1),
a
newly
discovered
lncRNA
located
on
chromosome
15q24.1,
has
recently
been
shown
be
involved
the
occurrence
and
progression
of
various
malignancies,
such
as
colorectal
cancer,
gastric
hepatocellular
carcinoma,
prostate
non-small
cell
lung
ovarian
cervical
breast
glioma,
thymic
pancreatic
carcinoma.
LOXL1-AS1
acts
competitive
endogenous
(ceRNA)
via
sponging
miRNAs,
including
miR-374b-5p,
miR-21,
miR-423-5p,
miR-589-5p,
miR-28-5p,
miR-324-3p,
miR-708-5p,
miR-143-3p,
miR-18b-5p,
miR-761,
miR-525-5p,
miR-541-3p,
miR-let-7a-5p,
miR-3128,
miR-3614-5p,
miR-377-3p
miR-1224-5p
promote
tumor
proliferation,
invasion,
migration,
apoptosis,
cycle,
epithelial–mesenchymal
transformation
(EMT).
In
addition,
is
regulation
P13K/AKT
MAPK
signaling
pathways.
This
article
reviews
current
understanding
biological
function
clinical
significance
cancers.
These
findings
suggest
may
both
reliable
biomarker
potential
therapeutic
target
for
