Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 26, 2025
As
a
well-known
cancer
risk
region,
the
8q24
locus
is
frequently
amplified
in
variety
of
solid
tumors.
Here
we
identify
pseudogene-derived
oncogenic
lncRNA,
ZNF252P,
which
upregulated
types
by
copy
number
gain
as
well
c-Myc-mediated
transcriptional
activation.
Mechanistically,
ZNF252P
binds
and
drives
"phase
separation"
HNRNPK
ILF3
protein
nucleus
cytoplasm,
respectively,
to
transcriptionally
posttranscriptionally
activate
c-Myc,
thus
forming
c-Myc/ZNF252P/c-Myc
positive
feedback
loop.
These
findings
expand
understanding
relationship
between
genomic
instability
region
tumorigenesis
clarify
regulatory
mechanism
involved
transcription
posttranscription
from
perspective
RNA-mediated
nuclear
cytoplasmic
phase
separation,
sheds
light
on
dialogue
with
driver
oncogene
c-Myc.
The
pivotal
axis
ZNF252P/c-Myc
has
potential
promising
biomarker
therapeutic
target
development.
most
human
cancers.
Here,
authors
discover
that
located
8q24,
promotes
regulating
loop
through
separation
ILF3.
Cell Death Discovery,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Jan. 31, 2025
Abstract
The
Hippo
pathway
represents
a
highly
conserved
evolutionary
pathway,
dysfunction
of
which
has
been
implicated
in
various
diseases.
RNA-binding
proteins
(RBPs)
intricately
modulate
gene
expression
through
interacting
with
non-coding
RNAs
or
other
proteins.
To
data,
while
an
array
RBPs
have
identified
as
modulators
the
there
remains
notable
absence
comprehensive
review
addressing
mechanistic
regulations
transduction
signaling.
Herein,
this
aims
to
consolidate
recent
advances
and
elucidate
intricate
mechanisms
underlying
binding
target
RNA.
It
also
explores
dynamic
interplay
between
RBPs,
RNAs,
TFs,
DNA
on
chromatin.
Additionally,
it
outlines
future
perspectives,
including
essential
non-canonical
functions
emerging
roles
transcription
factors
(TFs)
genes
transcription.
Overall,
provides
insights
into
eukaryotic
RBP
regulation
crucial
signaling
cascades.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 12, 2025
Lung
cancer
is
one
of
the
deadliest
malignancies
worldwide,
with
distant
metastasis
being
a
major
cause
death.
However,
specific
mechanisms
lung
remain
unclear.
NcRNAs,
widely
present
type
non-coding
RNAs
in
body,
constitute
about
98%
human
genome,
lacking
protein-coding
capacity
but
involved
various
cellular
processes
such
as
proliferation,
apoptosis,
invasion,
and
migration.
Studies
have
shown
that
ncRNAs
play
crucial
role
cancer,
although
research
this
area
limited.
This
review
summarizes
biological
origins
functions
ncRNAs,
their
roles
metastasis,
discusses
potential
for
early
screening
therapeutic
applications
cancer.
Furthermore,
it
outlines
challenges
translating
basic
advancements
into
clinical
practice.
Cancer Reports,
Journal Year:
2025,
Volume and Issue:
8(2)
Published: Feb. 1, 2025
ABSTRACT
Background
The
World
Health
Organization
has
mentioned
breast
cancer
holds
the
highest
incidence
rate
among
all
types
of
globally.
Death‐associated
protein
kinase
2
(
DAPK2
)
is
a
serine/threonine
linked
to
various
forms
malignancy,
such
as
cancer.
This
assumes
pivotal
function
in
multitude
cellular
mechanisms,
including
apoptosis,
autophagy,
and
cell
migration.
Aims
study
aimed
LOC101928988
regulatory
effect
on
expression
Methods
In
this
study,
38
paired
tumoral
normal
tissues
were
selected
from
patients.
Quantitative
real‐time
PCR
was
used
analyze
.
interactions
its
intermediate
elements
with
predicted
by
docking
analysis.
Results
downregulated
tumor
compared
control
group.
Further
analysis
revealed
significant
positive
correlation
between
levels
adjacent
tissues.
A
comparison
gene
different
grades,
stages,
HER2
statuses
showed
findings.
ROC
curve
77%
72%
AUC
for
BC
tissue,
respectively.
Conclusions
Overall,
our
results
suggest
that
alterations
may
be
involved
initiation
progression
It
also
been
reported
probably
role
regulating
through
interaction
transcription
factors.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 26, 2025
As
a
well-known
cancer
risk
region,
the
8q24
locus
is
frequently
amplified
in
variety
of
solid
tumors.
Here
we
identify
pseudogene-derived
oncogenic
lncRNA,
ZNF252P,
which
upregulated
types
by
copy
number
gain
as
well
c-Myc-mediated
transcriptional
activation.
Mechanistically,
ZNF252P
binds
and
drives
"phase
separation"
HNRNPK
ILF3
protein
nucleus
cytoplasm,
respectively,
to
transcriptionally
posttranscriptionally
activate
c-Myc,
thus
forming
c-Myc/ZNF252P/c-Myc
positive
feedback
loop.
These
findings
expand
understanding
relationship
between
genomic
instability
region
tumorigenesis
clarify
regulatory
mechanism
involved
transcription
posttranscription
from
perspective
RNA-mediated
nuclear
cytoplasmic
phase
separation,
sheds
light
on
dialogue
with
driver
oncogene
c-Myc.
The
pivotal
axis
ZNF252P/c-Myc
has
potential
promising
biomarker
therapeutic
target
development.
most
human
cancers.
Here,
authors
discover
that
located
8q24,
promotes
regulating
loop
through
separation
ILF3.
