Advanced Materials,
Год журнала:
2024,
Номер
36(27)
Опубликована: Март 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Molecular Biomedicine,
Год журнала:
2024,
Номер
5(1)
Опубликована: Окт. 17, 2024
It
has
long
been
widely
acknowledged
that
ultraviolet
(UV)
light
is
an
environment
risk
factor
can
lead
to
cancer,
particularly
skin
cancer.
However,
it
worth
noting
UV
radiation
holds
potential
for
cancer
treatment
as
a
relatively
high-energy
electromagnetic
wave.
With
the
help
of
nanomaterials,
role
caught
increasing
attention
in
treatment.
In
this
review,
we
briefly
summarized
types
UV-induced
cancers,
including
malignant
melanoma,
squamous
cell
carcinoma,
basal
Merkel
carcinoma.
Importantly,
discussed
primary
mechanisms
underlying
carcinogenesis,
mutations
by
DNA
damage,
immunosuppression,
inflammation
and
epigenetic
alterations.
Historically
limited
its
shallow
penetration
depth,
introduction
nanomaterials
dramatically
transformed
utilization
The
direct
effect
itself
generally
leads
suppression
growth
initiation
apoptosis
ferroptosis.
also
be
utilized
activate
photosensitizers
reactive
oxygen
species
(ROS)
production,
sensitize
radiotherapy
achieve
controlled
drug
release.
Finally,
comprehensively
weigh
significant
risks
limitations
associated
with
therapeutic
use
radiation.
And
contradictory
exposure
promoting
inhibiting
tumor
discussed.
This
review
provides
clues
clinical
therapy
well
future
study
directions
field.
precise
delivery
control
or
wavelength
dose
effects
are
needed
thorough
understanding
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
X‐ray
induced
photodynamic
therapy
(X‐PDT)
leverages
penetrating
to
generate
singlet
oxygen
(
1
O
2
)
for
treating
deep‐seated
tumors.
However,
conventional
X‐PDT
typically
relies
on
heavy
metal
inorganic
scintillators
and
organic
photosensitizers
produce
,
which
presents
challenges
related
toxicity
energy
conversion
efficiency.
In
this
study,
highly
biocompatible
phosphorescent
nanoscintillators
based
hydrogen‐bonded
frameworks
(HOF)
are
designed
engineered,
termed
BPT‐HOF@PEG,
enhance
in
hepatocellular
carcinoma
(HCC)
treatment.
BPT‐HOF@PEG
functions
simultaneously
as
both
scintillator
photosensitizer,
effectively
absorbing
transferring
abundant
.
Both
vitro
vivo
investigations
demonstrate
that
internalized
efficiently
produces
significant
quantities
of
upon
irradiation.
Additionally,
exposure
directly
inflicts
DNA
damage,
the
synergistic
effects
these
mechanisms
result
pronounced
cell
death
substantial
tumor
growth
inhibition,
with
a
inhibition
rate
up
90.4%
assessments.
RNA
sequencing
analyses
reveal
induces
apoptosis
Hepa1‐6
cells
while
inhibiting
proliferation,
culminating
death.
Therefore,
work
highlights
considerable
potential
efficient
HOF
nanoscintillators‐based
promising
therapeutic
approach
HCC,
providing
effective
alternative
negligible
patients
unresectable
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Март 18, 2025
In
the
domain
of
addressing
cancer
resistance,
challenges
such
as
limited
effectiveness
and
treatment
resistance
remain
persistent.
Hypoxia
is
a
key
feature
solid
tumors
strongly
associated
with
poor
prognosis
in
patients.
Another
significant
portion
development
acquired
drug
attributed
to
tumor
stemness.
Cancer
stem
cells
(CSCs),
small
cell
subset
self-renewal
proliferative
abilities,
are
crucial
for
initiation,
metastasis,
intra-tumoral
heterogeneity.
Studies
have
shown
association
between
hypoxia
CSCs
context
resistance.
Recent
studies
reveal
strong
link
stemness,
which
together
promote
survival
progression
during
treatment.
This
review
elucidates
interplay
CSCs,
well
their
correlation
therapeutic
drugs.
Targeting
pivotal
genes
stemness
holds
promise
novel
therapeutics
combat
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(12), С. 5106 - 5131
Опубликована: Ноя. 2, 2024
Reactive
oxygen
species
(ROS)-responsive
drug
delivery
systems
(DDSs)
have
garnered
significant
attention
in
cancer
research
because
of
their
potential
for
precise
spatiotemporal
release
tailored
to
high
ROS
levels
within
tumors.
Despite
the
challenges
posed
by
distribution
heterogeneity
and
endogenous
supply
constraints,
this
review
highlights
strategic
alliance
ROS-responsive
DDSs
with
photodynamic
therapy
(PDT),
enabling
selective
leveraging
PDT-induced
enhanced
therapeutic
efficacy.
This
delves
into
biological
importance
progression
treatment.
We
elucidate
detail
operational
mechanisms
linkers,
including
thioether,
thioketal,
selenide,
diselencide,
telluride
aryl
boronic
acids/esters,
as
well
latest
developments
nanomedicines
that
integrate
PDT
strategies.
These
insights
are
intended
inspire
design
innovative
nanocarriers
PDT.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 8, 2025
Radiotherapy
(RT)
is
the
primary
treatment
modality
for
nasopharyngeal
carcinoma
(NPC).
However,
tumor
microenvironment
(TME)-induced
radioresistance
often
compromises
its
therapeutic
efficacy.
Herein,
we
propose
an
innovative
bidirectional
radiosensitization
strategy
NPC.
Specifically,
have
encapsulated
metformin
(Met)
and
copper
sulfide
nanoparticles
(CuS
NPs)
within
injectable
DNA
supramolecular
hydrogels
(DSH)
to
create
a
novel
radiosensitizer,
Met-CuS@DSH.
This
radiosensitizer
not
only
effectively
reverses
hypoxia
promote
reactive
oxygen
species
(ROS)
generation
but
also
significantly
inhibits
glutathione
(GSH)-mediated
ROS
scavenging,
thereby
achieving
by
enhancing
production
suppressing
scavenging.
improves
effect
of
NPC
while
reducing
RT
dose
(3
Gy
in
total),
which
provides
promising
approach
overcoming
caused
TME.
Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Июнь 3, 2024
Leading
anti-tumour
therapeutic
strategies
typically
involve
surgery
and
radiotherapy
for
locally
advanced
(non-metastatic)
cancers,
while
hormone
therapy,
chemotherapy,
molecular
targeted
therapy
are
the
current
treatment
options
metastatic
cancer.
Despite
initially
high
sensitivity
rate
to
anticancer
therapies,
a
large
number
of
patients
develop
resistance,
leading
poor
prognosis.
The
mechanisms
related
drug
resistance
highly
complex,
long
non-coding
RNAs
appear
play
crucial
role
in
these
processes.
Among
these,
lncRNA
homeobox
transcript
antisense
intergenic
RNA
(HOTAIR),
widely
implicated
cancer
initiation
progression,
likewise
plays
significant
resistance.
It
can
modulate
cell
activities
such
as
proliferation,
apoptosis,
hypoxia,
autophagy,
well
epithelial-mesenchymal
transition,
thereby
contributing
development
resistant
tumour
cells.
In
this
manuscript,
we
describe
different
antitumor
which
HOTAIR
is
involved
suggest
its
potential
predictive
biomarker
management
patients.
Molecular Carcinogenesis,
Год журнала:
2024,
Номер
63(11), С. 2119 - 2132
Опубликована: Июль 26, 2024
Many
studies
have
shown
that
tumor
cells
survive
radiotherapy
are
more
likely
to
metastasize,
but
the
underlying
mechanism
remains
unclear.
Here
we
aimed
identify
epithelial-mesenchymal
transition
(EMT)-related
key
genes,
which
associated
with
prognosis
and
radiosensitivity
in
rectal
cancer.
First,
obtained
differentially
expressed
genes
by
analyzing
RNA
expression
profiles
of
cancer
retrieved
from
The
Cancer
Genome
Atlas
database,
EMT-related
radiotherapy-related
databases,
respectively.
Then,
Lasso
Cox
regression
analyses
were
used
establish
an
model
(EMTPM)
based
on
identified
independent
protective
factor
Fibulin5
(FBLN5)
risk
gene
EHMT2.
high-EMTPM
group
exhibited
significantly
poorer
prognosis.
evaluated
signature
external
clinical
validation
cohort.
Through
vivo
experiments,
further
demonstrated
EMTPM
effectively
distinguishes
radioresistant
radiosensitive
patients
Moreover,
individuals
showed
increased
immune
checkpoints
compared
their
counterparts.
Finally,
pan-cancer
analysis
also
indicated
its
potential
for
predicting
lung
squamous
cell
carcinoma
breast
undergoing
radiotherapy.
In
summary,
established
a
novel
predictive
radioresistance
FBLN5
EHMT2
expressions,
suggested
microenvironment
may
be
involved
process
radioresistance.
This
could
select
management
strategies
