Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Язык: Английский
Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer
Seminars in Cancer Biology,
Год журнала:
2024,
Номер
106-107, С. 43 - 57
Опубликована: Авг. 29, 2024
Язык: Английский
Radiotherapy‐Associated Cellular Senescence and EMT Alterations Contribute to Distinct Disease Relapse Patterns in Locally Advanced Cervical Cancer
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Abstract
A
notable
number
of
locally
advanced
cervical
carcinoma
(LACC)
patients
experience
local
or
distant
disease
relapse
following
radiotherapy.
The
contribution
tumor
microenvironment
(TME)
to
recurrence
at
different
sites
remains
unclear.
Here,
single‐nucleus
RNA
sequencing
data
from
28
pre‐
and
on‐treatment
LACC
samples
with
patterns
is
analyzed.
findings
revealed
opposing
alterations
in
the
expression
levels
cellular
senescence
pathway
after
radiotherapy
relapses.
In
contrast,
an
increase
epithelial‐mesenchymal
transition
module
both
groups
observed.
Cell–cell
interactions,
drug‐target
analyses
malignant
cells
radiation,
multiplex
immunofluorescence
tissue
identified
interleukin‐1
receptor
type
I
(IL1R1)
as
a
potential
therapeutic
target.
It
demonstrated
that
combining
IL1R1
inhibitor
anakinra
radiation
can
mitigate
effects
on
cells.
This
study
highlights
distinct
roles
EMT
recurrence.
Язык: Английский
CD34+CLDN5+ tumor associated senescent endothelial cells through IGF2-IGF2R signaling increased cholangiocellular phenotype in hepatocellular carcinoma
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
The
heterogeneity
of
hepatocellular
carcinoma
(HCC)
is
linked
to
tumor
malignancy
and
poor
prognosis.
Nevertheless,
the
precise
mechanisms
underlying
development
cholangiocellular
phenotype
(CCA)
within
HCC
remain
unclear.
Emerging
studies
support
that
cross-talk
among
host
cells
microenvironment
(TME)
sustains
cancer
cell
plasticity.
This
study
sought
identify
specific
types
involved
in
formation
CCA
elucidate
their
functional
roles
progression
HCC.
Single-cell
RNA
sequencing
was
employed
CCA.
Both
vitro
vivo
analyses
were
used
tumor-associated
senescent
ECs
investigate
function
TME.
diethylnitrosamine-induced
model
utilized
interaction
between
MSCs,
aiming
synergistic
contributions
Using
single-cell
sequencing,
we
identified
a
distinct
senescent-associated
subset
endothelial
(ECs),
namely
CD34+CLDN5+
ECs,
which
mainly
enriched
tissue.
Further,
observed
secrete
IGF2,
recruited
mesenchymal
stem
(MSCs)
into
TME
through
IGF2R/MAPK
signaling.
In
primary
liver
model,
MSCs
exhibited
strong
tumor-promoting
effect,
increasing
after
formation.
Interestingly,
knockdown
IGF2R
expression
inhibited
increase
caused
by
Meanwhile,
it
revealed
released
multiple
inflammatory
trophic-related
cytokines
enhance
cell-like
characteristics
cells.
Finally,
demonstrated
CEBPβ
up-regulated
IGF2
combining
with
Igf2-promtor-sequence.
Together,
our
findings
illustrated
associated
TME,
enhancing
(CSC)-like
features
contributing
Язык: Английский
Detecting cell types and densities in the tumor microenvironment improves prognostic risk assessment for breast cancer
Biomolecules and Biomedicine,
Год журнала:
2024,
Номер
25(1), С. 106 - 114
Опубликована: Авг. 16, 2024
A
comprehensive
evaluation
of
the
relationship
between
densities
various
cell
types
in
breast
cancer
tumor
microenvironment
and
patient
prognosis
is
currently
lacking.
Additionally,
absence
a
large
patch-level
whole
slide
imaging
(WSI)
dataset
with
annotated
hinders
ability
artificial
intelligence
to
evaluate
density
WSI.
We
first
employed
Lasso-Cox
regression
build
assessment
model
based
on
population
study.
Pathology
experts
manually
containing
over
70,000
patches
used
transfer
learning
ResNet152
develop
an
for
identifying
different
these
patches.
The
results
showed
that
significant
prognostic
differences
were
observed
among
patients
stratified
by
score
(P
=
0.0018),
identified
as
independent
factor
<
0.05).
In
validation
cohort,
predictive
performance
overall
survival
(OS)
was
satisfactory,
area
under
curve
(AUC)
values
0.893
at
1-year,
0.823
3-year,
0.861
5-year
intervals.
trained
robust
ResNet152,
achieving
99%
classification
accuracy
These
achievements
offer
new
public
resources
tools
personalized
treatment
assessment.
Язык: Английский
Response to Letter to the Editor, “Senolytic Treatment Improve Small Intestine Regeneration in Aging”
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Язык: Английский
New Relevant Evidence in Cholangiocarcinoma Biology and Characterization
Cancers,
Год журнала:
2024,
Номер
16(24), С. 4239 - 4239
Опубликована: Дек. 19, 2024
Among
solid
tumors,
cholangiocarcinoma
(CCA)
emerges
as
one
of
the
most
difficult
to
eradicate.
The
silent
and
asymptomatic
nature
this
tumor,
particularly
in
its
early
stages,
well
high
heterogeneity
at
genomic,
epigenetic,
molecular
levels
delay
diagnosis,
significantly
compromising
efficacy
current
therapeutic
options
thus
contributing
a
dismal
prognosis.
Extensive
research
has
been
conducted
on
pathobiology
CCA,
recent
advances
have
made
classification
characterization
new
targets.
Both
targeted
therapy
immunotherapy
emerged
effective
safe
strategies
for
various
types
cancers,
demonstrating
potential
benefits
advanced
CCA.
Furthermore,
deeper
comprehension
cellular
components
tumor
microenvironment
(TME)
opened
up
possibilities
innovative
treatment
methods.
This
review
discusses
evidence
biology
highlighting
novel
possible
druggable
Язык: Английский