Neuroscience, Год журнала: 2024, Номер 565, С. 52 - 62
Опубликована: Ноя. 29, 2024
Язык: Английский
Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15
Опубликована: Июль 6, 2023
Vagus nerve stimulation (VNS) is a technology that provides electrical to the cervical vagus and can be applied in treatment of wide variety neuropsychiatric systemic diseases. VNS exerts its effect by stimulating vagal afferent efferent fibers, which project upward brainstem nuclei relayed circuits downward internal organs influence autonomic, neuroendocrine, neuroimmunology systems. The neuroimmunomodulation mediated through cholinergic anti-inflammatory pathway regulates immune cells decreases pro-inflammatory cytokines. Traditional non-invasive have Food Drug Administration (FDA)-approved indications for patients with drug-refractory epilepsy, treatment-refractory major depressive disorders, headaches. number clinical trials translational studies explore therapeutic potentials mechanisms increasing. In this review, we first introduced anatomical physiological bases immunomodulating functions VNS. We covered investigated implications spectrum brain disorders diseases context neuroimmunomodulation.
Язык: Английский
Процитировано
41
Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13
Опубликована: Апрель 17, 2023
Depression is one of the most common psychiatric conditions, characterized by significant and persistent depressed mood diminished interest, often coexists with various comorbidities. The underlying mechanism depression remain elusive, evidenced lack an appreciate therapy. Recent abundant clinical trials animal studies support new notion that gut microbiota has emerged as a novel actor in pathophysiology depression, which partakes bidirectional communication between brain through neuroendocrine, nervous, immune signaling pathways, collectively known microbiota-gut-brain (MGB) axis. Alterations can trigger changes neurotransmitters, neuroinflammation, behaviors. With transition human microbiome research from studying associations to investigating mechanistic causality, MGB axis therapeutic target its These insights have fueled idea targeting on may open windows for efficient treatment Probiotics, live beneficial microorganisms, be used modulate dysbiosis into eubiosis modify occurrence development In present review, we summarize recent findings regarding discuss potential effects probiotics
Язык: Английский
Процитировано
30
Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16
Опубликована: Фев. 27, 2024
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the distributed over body surface. Studies suggest a correlation between brain-gut-microbiota (BGM) axis and pathogenesis Alzheimer’s disease (AD). The BGM represents complex bidirectional communication system, with being crucial component. Therefore, electrical might have potential modify—most time probably in non-physiological way—the signal transmission within axis, potentially influencing progression or symptoms AD. This review explores interaction percutaneous emphasizing its effects on It examines various aspects, such as specific brain regions, gut microbiota composition, maintenance intestinal environmental homeostasis, inflammatory responses, plasticity, hypothalamic–pituitary–adrenal (HPA) regulation. suggests that tVNS could serve effective strategy modulate intervene treatment future.
Язык: Английский
Процитировано
12
Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown
Опубликована: Июнь 27, 2024
Abstract As the population ages, cognitive decline becomes more common. Strategies targeting gut-brain axis using probiotics are emerging to achieve improvements in neuropsychiatric and neurological disorders. However, beneficial role of on brain function healthy older adults remains unclear. Our aim was evaluate a multi-species probiotic formulation as therapeutic approach reduce emotional associated with aging adults. A randomized double-blind placebo-controlled crossover trial conducted. The study involved 10-week intervention where participants consumed assigned product daily, followed by 4-week washout period before second condition started. Cognitive assessed Mini-Mental State Examination (MMSE) Psychological Experiments Construction Language Test Battery. At level, Beck Depression Inventory (BDI) State-Trait Anxiety (STAI) were used. Thirty-three participants, recruited between July 2020 April 2022, ingested multispecies ( Lactobacillus rhamnosus Bifidobacterium lactis ). After intervention, noticeable enhancements observed (mean difference 1.90, 95% CI 1.09 2.70, p < 0.005), memory 4.60, 2.91 6.29, 0.005) MMSE digit task, depressive symptoms 4.09, 1.70 6.48, BDI. Furthermore, there significant planning problem-solving skills, selective attention, flexibility, impulsivity, inhibitory ability. Probiotics administration improved Limited research supports this, requiring scientific evidence for an effective therapy decline. This has been prospectively registered at ClinicalTrials.gov (NCT04828421; 2020/July/17).
Язык: Английский
Процитировано
9
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 27, 2025
The gut–brain axis, a bidirectional communication pathway, permits the central nervous system (CNS) to exert influence over gastrointestinal function in response stress, while gut microbiota regulates CNS via immune, neuroendocrine, and vagal pathways. Current research highlights importance of stress-related disorders need for further into mechanisms communication, with potential therapeutic implications wide range health conditions. This is challenge taken on this Scientific Reports Collection Gut-Brain Axis. axis has significant neurodegenerative, psychiatric, metabolic disorders. Recent studies have underscored role microbiome conditions such as Parkinson's disease (PD), evidence indicating that dysfunction pathological features can precede motor symptoms by decades. use vivo animal models demonstrated preformed α-synuclein fibrils (PFFs) travel from brain dosage-dependent manner, thereby supporting "gut-first" theory context PD, explored using vitro approaches. There also plays obesity machine learning algorithms may assist differentiating between obese overweight individuals based their data. growing interest at interface post-traumatic stress disorder (PTSD), sleep disturbances, irritable bowel syndrome (IBS). described support expand observations previous preclinical clinical investigations, providing essential novel insights drive discovery previously unexplored avenues brain-gut-microbiome interactions disease.
Язык: Английский
Процитировано
1
Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102515 - 102515
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
8
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 13
Опубликована: Янв. 31, 2024
Migraine is a prevalent clinical disorder characterized by recurrent unilateral throbbing headache episodes accompanied symptoms such as nausea, vomiting, photophobia, and phonophobia. Despite its common occurrence, the diagnosis, pathophysiology, treatment of migraine remain controversial. Extensive research has implicated gut microbiota in various central nervous system disorders, including anxiety depression, Parkinson's disease. Some studies have also suggested that may stem from disruptions to neurohormones metabolism. This study aimed investigate disparities metabolites between mice model normal shed light on underlying mechanisms potential therapeutic approaches. Distinct differences microbial composition were observed mouse mouse, indicating correlation these variations pathogenesis migraine. provides evidence mice, which showed Akkermansiaceae constituted most abundant taxon sham injection group, while Lachnospiraceae group group. The associations abundances Akkermansia muciniphila bacteria their roles altered abundance migraine-afflicted correlations with changes suggest it affect host's health. Thus, probiotic therapy emerges possible for Moreover, significant mice. These alterations encompass multiple metabolic pathways, suggesting disturbances contribute development migraines.
Язык: Английский
Процитировано
6
Biomedicines, Год журнала: 2024, Номер 12(8), С. 1719 - 1719
Опубликована: Авг. 1, 2024
Arrhythmias and depression are recognized as diseases of the heart brain, respectively, both major health threats that often co-occur with a bidirectional causal relationship. The autonomic nervous system (ANS) serves crucial component heart–brain axis (HBA) pathway interoception. Cardiac activity can influence emotional states through ascending interoceptive pathways, while psychological stress precipitate arrhythmias via ANS. However, HBA interoception frameworks considered overly broad, precise mechanisms underlying relationship between remain unclear. This narrative review aims to synthesize existing literature, focusing on pathological ANS in arrhythmia integrating other potential detail interactions. In communication we emphasize considering various internal factors such genes, personality traits, stress, endocrine system, inflammation, 5-hydroxytryptamine, behavioral factors. Current research employs multidisciplinary knowledge elucidate relationships, deeper understanding these interactions help optimize clinical treatment strategies. From broader perspective, this study emphasizes importance body complex, interconnected rather than treating organs isolation. Investigating enhance our disease pathogenesis advances medical science, ultimately improving human quality life.
Язык: Английский
Процитировано
5
Perspectives on Psychological Science, Год журнала: 2023, Номер unknown
Опубликована: Сен. 11, 2023
Embodied cognition-the idea that mental states and processes should be understood in relation to one's bodily constitution interactions with the world-remains a controversial topic within cognitive science. Recently, however, increasing interest predictive processing theories among proponents critics of embodiment alike has raised hopes reconciliation. This article sets out appraise unificatory potential processing, focusing particular on embodied formulations active inference. Our analysis suggests most active-inference accounts invoke weak, potentially trivial conceptions embodiment; those making stronger claims do so independently theoretical commitments framework. We argue more compelling version inference can motivated by adopting diachronic perspective way rhythmic physiological activity shapes neural development utero. According this visceral afferent training hypothesis, early-emerging are essential not only for supporting biophysical structures but also configuring architecture entail. Focusing cardiovascular system, we propose three candidate mechanisms through which might operate: (a) activity-dependent neuronal development, (b) periodic signal modeling, (c) oscillatory network coordination.
Язык: Английский
Процитировано
12
Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 16
Опубликована: Янв. 14, 2025
Transcutaneous vagus nerve stimulation (tVNS) has emerged as a novel noninvasive adjunct therapy for advanced Parkinson's disease (PD), yet no quantitative analysis had been conducted to assess its therapeutic effect. This review aimed investigate the efficacy of tVNS on motor function, other potential clinical targets and safety in various treatment conditions. We searched six databases randomized controlled trials (RCTs) that involved treating PD patients with tVNS. Primary outcome was functions, including severity signs, functional mobility balance, gait parameters. Secondary outcomes were cognition, emotion, sleep related impairments, patient reported non-motor outcomes, any adverse events. All classified analyzed according duration medication condition an included study. Risk bias evaluated by referencing Cochrane risk tool 1.0. Data Revman 5.4. 6 RCTs 176 included. Several functions measured during on-medication (severity signs -0.48 [95% CI -0.93, -0.04], -0.85, -0.1], -0.4 -0.78, -0.03]), improved significantly. However, verbal fluency, sleep-related impairment, fatigue negatively impacted condition. No distinct events reported. is relatively safe PD. It small moderate effects may impact few outcomes. Quality level evidence low further research warranted. https://www.crd.york.ac.uk/prospero/#recordDetails, identifier CRD42024503322 (PROSPERO).
Язык: Английский
Процитировано
0