Seminars in Cell and Developmental Biology, Год журнала: 2023, Номер 157, С. 1 - 2
Опубликована: Дек. 2, 2023
Cancer Letters, Год журнала: 2024, Номер 598, С. 217079 - 217079
Опубликована: Июнь 25, 2024
Язык: Английский
Процитировано
11
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 4, 2025
Photodynamic-induced immunotherapy (PDI) is often hampered by low reactive oxygen species (ROS) yield, intra-tumor hypoxia, high glutathione (GSH) concentration, and immunosuppressive microenvironment. In view of this, a ruthenium (Ru)-based nanobattery (termed as IRD) with cascade-charged (O2), ROS, photodynamic-induced coordination-driven self-assembly transition-metal Ru, photosensitizer indocyanine green (ICG), organic ligand dithiobispropionic acid (DTPA). Then, IRD camouflaged macrophage membranes to obtain IRD@M) targeting immune evasion capabilities. Upon intravenous administration, IRD@M core-shell structure, nano diameter, good stability can specifically hoard in tumor location internalize into cells. disassembly triggered GSH, the released Ru³⁺ not only catalyzes conversion endogenous hydrogen peroxide (H₂O₂) O₂ alleviate hypoxia reduce expression hypoxia-inducible factor-1α (HIF-1α), but also generates hydroxyl radicals (·OH) elevate intracellular ROS levels. This process significantly enhances photodynamic therapy (PDT) efficacy ICG. Meanwhile, DTPA downregulate overexpressed GSH elimination deriving from PDT exchange reaction thiol-disulfide bond. It found that alleviating hypoxic microenvironment synergistically efficacy, which turn cascades recharge subsequent response, improving activating systemic tumor-specific immunity. Notably, vitro vivo experimental results jointly confirm such cascade-recharged macrophage-biomimetic Ru-based achieve an obvious while minimized side effect. Taken together, this work highlights promising strategy for simple, flexible, effective immunogenic cell death (ICD) agents within PDI.
Язык: Английский
Процитировано
0
Sensors and Actuators Reports, Год журнала: 2025, Номер unknown, С. 100316 - 100316
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2024, Номер 586, С. 216695 - 216695
Опубликована: Фев. 5, 2024
Язык: Английский
Процитировано
2
Journal of Ethnopharmacology, Год журнала: 2024, Номер 338, С. 118955 - 118955
Опубликована: Окт. 18, 2024
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 3, 2024
Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, a novel therapeutic methodology, opened up new possibilities for colorectal patients. However, its actual clinical efficacy requires further enhancement. Copper, an exceptionally crucial trace element, can influence various signaling pathways, gene expression, and biological metabolic processes in cells, thus playing critical role pathogenesis cancer. Recent studies have revealed that cuproptosis, mode cell death, holds promise to become potential target overcome resistance immunotherapy. This shows substantial combination treatment Conveying copper into tumor cells via nano-drug delivery system induce cuproptosis could offer strategy eliminating drug-resistant vastly improving immunotherapy while ultimately destroy tumors. Moreover, combining induction with other anti-tumor approaches such photothermal therapy, photodynamic chemodynamic therapy enhance effect. review aims illuminate practical significance cuproptosis-inducing nano-drugs immunotherapy, scrutinize current challenges limitations this thereby providing innovative thoughts references advancement cuproptosis-based strategies.
Язык: Английский
Процитировано
1
Cancer Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 12, 2024
Abstract Near‐infrared photoimmunotherapy (NIR‐PIT) is a novel antitumor therapy that selectively kills cancer cells by NIR light‐triggered photochemical reaction of IRDye700DX within Ab–photoabsorber conjugates (APCs). NIR‐PIT induces immunogenic cell death, causing immune migration between the tumor and tumor‐draining lymph nodes, expanding multiclonal tumor‐infiltrating CD8 + T cells. Crucially, cytotoxic effects are limited to cells, sparing such as antigen‐presenting which key players in boosting host immunity. By modifying Ab used APC synthesis, can be repurposed target deplete noncancerous immunosuppressive including regulatory myeloid‐derived suppressor cancer‐associated fibroblasts microenvironment. Immunosuppressive targeted strongly potentiates immunity, induction abscopal development memory. Furthermore, responses therapeutic efficacy synergistically enhanced when combined with other immune‐activating treatments, interleukin‐15 checkpoint inhibitors. These new findings make valuable tool evolving landscape immunotherapy. This review explains role activating
Язык: Английский
Процитировано
1
OncoImmunology, Год журнала: 2024, Номер 13(1)
Опубликована: Ноя. 21, 2024
Few clinical studies investigated the putative link between activation of immunogenic cell death (ICD) and oncological outcome. Recent data, published in a Phase 1b trial, demonstrated that an ICD-associated surge plasma concentration high-mobility group box 1 (HMGB1) indicates favorable prognosis patients with advanced leiomyosarcomas treated combination doxorubicin, dacarbazine nivolumab.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 29, 2024
Combined chemo-photothermal therapy (CHT-PTT) is a promising treatment for metastatic cancers. It enables the synergistic induction of immunogenic cell death (ICD), while sensitising suppressive tumour microenvironment to immunotherapy. To induce ICD, rational design combined CHT-PTT regimen remains unclear. In present study, black porous silicon nanoparticles (BPSi NPs) were utilized as both drug carriers and photothermal conversion agents. enhance their colloidal stability homotypic targeting, BPSi NP surfaces modified with polyethylene glycol further coated cancer membranes (CMs). Six chemotherapeutic drugs different growth inhibition mechanisms tested against MDA-MB-231 breast cells evaluate ICD potentials. Finally, in CHT-PTT, effect temperature was evaluated. Based on analysis markers, high-mobility group box 1 calreticulin proteins, we found that bromodomain-containing protein 4 inhibitor, (+)-JQ-1 (JQ1) optimal drug, mild-hyperthermia 45 °C best setting ICD. Thus, our study provides rationally designed efficient high efficacy low side effects.
Язык: Английский
Процитировано
0
Human Vaccines & Immunotherapeutics, Год журнала: 2024, Номер 20(1)
Опубликована: Дек. 10, 2024
Immunogenic cell death (ICD) is a distinct type of stress-induced regulated that can lead to adaptive immune responses and the establishment immunological memory. ICD exhibits both similarities differences when compared apoptosis other non-apoptotic forms (RCD). The interplay between ICD-mediated immunosurveillance against cancer ability cells evade influences host-tumor interaction. Consequently, restoration development effective strategies induce have emerged as crucial considerations in treatment within context immunotherapy. To enhance comprehension setting cancer, this paper examines interconnected responsive pathways associated with ICD, corresponding biomarkers indicative mechanisms through which tumors subvert ICD. Additionally, review explores for reinstating therapeutic potential harnessing
Язык: Английский
Процитировано
0