Editorial: Special issue SCDB “Cell death and survival” DOI

Maddalena Nano,

Denise J. Montell

Seminars in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 157, P. 1 - 2

Published: Dec. 2, 2023

Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination DOI
Zhaokai Zhou, Yumiao Mai, Ge Zhang

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217079 - 217079

Published: June 25, 2024

Language: Английский

Citations

11
Cascade-recharged macrophage-biomimetic ruthenium-based nanobattery for enhanced photodynamic-induced immunotherapy DOI Creative Commons

Guoyu Xia,

Zhongxiong Fan, Qi Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

Photodynamic-induced immunotherapy (PDI) is often hampered by low reactive oxygen species (ROS) yield, intra-tumor hypoxia, high glutathione (GSH) concentration, and immunosuppressive microenvironment. In view of this, a ruthenium (Ru)-based nanobattery (termed as IRD) with cascade-charged (O2), ROS, photodynamic-induced coordination-driven self-assembly transition-metal Ru, photosensitizer indocyanine green (ICG), organic ligand dithiobispropionic acid (DTPA). Then, IRD camouflaged macrophage membranes to obtain IRD@M) targeting immune evasion capabilities. Upon intravenous administration, IRD@M core-shell structure, nano diameter, good stability can specifically hoard in tumor location internalize into cells. disassembly triggered GSH, the released Ru³⁺ not only catalyzes conversion endogenous hydrogen peroxide (H₂O₂) O₂ alleviate hypoxia reduce expression hypoxia-inducible factor-1α (HIF-1α), but also generates hydroxyl radicals (·OH) elevate intracellular ROS levels. This process significantly enhances photodynamic therapy (PDT) efficacy ICG. Meanwhile, DTPA downregulate overexpressed GSH elimination deriving from PDT exchange reaction thiol-disulfide bond. It found that alleviating hypoxic microenvironment synergistically efficacy, which turn cascades recharge subsequent response, improving activating systemic tumor-specific immunity. Notably, vitro vivo experimental results jointly confirm such cascade-recharged macrophage-biomimetic Ru-based achieve an obvious while minimized side effect. Taken together, this work highlights promising strategy for simple, flexible, effective immunogenic cell death (ICD) agents within PDI.

Language: Английский

Citations

0
Novel L-cysteine-functionalized Au@MnO2/MoO3 nanocomposites for electrochemical detection of apoptosis-related proteins in immunogenic cell death of patient-derived lung cancer cells DOI Creative Commons
Yi‐An Chen, Ming‐You Shie,

Kai Chang

et al.

Sensors and Actuators Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100316 - 100316

Published: March 1, 2025

Language: Английский

Citations

0
Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway DOI
Zhaoshi Bai,

Yaling Peng,

Xue'er Xia

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 586, P. 216695 - 216695

Published: Feb. 5, 2024

Language: Английский

Citations

2
Traditional Chinese medicine enhances the effectiveness of immune checkpoint inhibitors in tumor treatment: A mechanism discussion DOI
Manting Wang, Fan Yang,

Jingwei Kong

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 118955 - 118955

Published: Oct. 18, 2024

Language: Английский

Citations

1
Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer DOI Creative Commons
Xiangdong Liu, Wanqiu Zhang,

Shaozhong Wei

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 3, 2024

Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, a novel therapeutic methodology, opened up new possibilities for colorectal patients. However, its actual clinical efficacy requires further enhancement. Copper, an exceptionally crucial trace element, can influence various signaling pathways, gene expression, and biological metabolic processes in cells, thus playing critical role pathogenesis cancer. Recent studies have revealed that cuproptosis, mode cell death, holds promise to become potential target overcome resistance immunotherapy. This shows substantial combination treatment Conveying copper into tumor cells via nano-drug delivery system induce cuproptosis could offer strategy eliminating drug-resistant vastly improving immunotherapy while ultimately destroy tumors. Moreover, combining induction with other anti-tumor approaches such photothermal therapy, photodynamic chemodynamic therapy enhance effect. review aims illuminate practical significance cuproptosis-inducing nano-drugs immunotherapy, scrutinize current challenges limitations this thereby providing innovative thoughts references advancement cuproptosis-based strategies.

Language: Английский

Citations

1
Antitumor host immunity enhanced by near‐infrared photoimmunotherapy DOI Creative Commons
Hiroshi Fukushima, Aki Furusawa, Ryuhei Okada

et al.

Cancer Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Near‐infrared photoimmunotherapy (NIR‐PIT) is a novel antitumor therapy that selectively kills cancer cells by NIR light‐triggered photochemical reaction of IRDye700DX within Ab–photoabsorber conjugates (APCs). NIR‐PIT induces immunogenic cell death, causing immune migration between the tumor and tumor‐draining lymph nodes, expanding multiclonal tumor‐infiltrating CD8 + T cells. Crucially, cytotoxic effects are limited to cells, sparing such as antigen‐presenting which key players in boosting host immunity. By modifying Ab used APC synthesis, can be repurposed target deplete noncancerous immunosuppressive including regulatory myeloid‐derived suppressor cancer‐associated fibroblasts microenvironment. Immunosuppressive targeted strongly potentiates immunity, induction abscopal development memory. Furthermore, responses therapeutic efficacy synergistically enhanced when combined with other immune‐activating treatments, interleukin‐15 checkpoint inhibitors. These new findings make valuable tool evolving landscape immunotherapy. This review explains role activating

Language: Английский

Citations

1
High circulating HMGB1 indicates good prognosis in patients with advanced leiomyosarcoma under chemoimmunotherapy DOI Creative Commons
Lucillia Bezu,

Guido Kroemer

OncoImmunology, Journal Year: 2024, Volume and Issue: 13(1)

Published: Nov. 21, 2024

Few clinical studies investigated the putative link between activation of immunogenic cell death (ICD) and oncological outcome. Recent data, published in a Phase 1b trial, demonstrated that an ICD-associated surge plasma concentration high-mobility group box 1 (HMGB1) indicates favorable prognosis patients with advanced leiomyosarcomas treated combination doxorubicin, dacarbazine nivolumab.

Language: Английский

Citations

0
Biomimetic porous silicon for rationally engineered combination therapy to induce immunogenic cell death DOI Creative Commons

Silja Saarela,

Emilia Happonen,

Milla-Iida Laari

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Combined chemo-photothermal therapy (CHT-PTT) is a promising treatment for metastatic cancers. It enables the synergistic induction of immunogenic cell death (ICD), while sensitising suppressive tumour microenvironment to immunotherapy. To induce ICD, rational design combined CHT-PTT regimen remains unclear. In present study, black porous silicon nanoparticles (BPSi NPs) were utilized as both drug carriers and photothermal conversion agents. enhance their colloidal stability homotypic targeting, BPSi NP surfaces modified with polyethylene glycol further coated cancer membranes (CMs). Six chemotherapeutic drugs different growth inhibition mechanisms tested against MDA-MB-231 breast cells evaluate ICD potentials. Finally, in CHT-PTT, effect temperature was evaluated. Based on analysis markers, high-mobility group box 1 calreticulin proteins, we found that bromodomain-containing protein 4 inhibitor, (+)-JQ-1 (JQ1) optimal drug, mild-hyperthermia 45 °C best setting ICD. Thus, our study provides rationally designed efficient high efficacy low side effects.

Language: Английский

Citations

0
Immunogenic cell death: A new strategy to enhancing cancer immunotherapy DOI Creative Commons
Lei Dou, Yu Fang, Huiyuan Yang

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: Dec. 10, 2024

Immunogenic cell death (ICD) is a distinct type of stress-induced regulated that can lead to adaptive immune responses and the establishment immunological memory. ICD exhibits both similarities differences when compared apoptosis other non-apoptotic forms (RCD). The interplay between ICD-mediated immunosurveillance against cancer ability cells evade influences host-tumor interaction. Consequently, restoration development effective strategies induce have emerged as crucial considerations in treatment within context immunotherapy. To enhance comprehension setting cancer, this paper examines interconnected responsive pathways associated with ICD, corresponding biomarkers indicative mechanisms through which tumors subvert ICD. Additionally, review explores for reinstating therapeutic potential harnessing

Language: Английский

Citations

0