Pharmaceuticals,
Год журнала:
2024,
Номер
17(12), С. 1596 - 1596
Опубликована: Ноя. 27, 2024
Background:
Curcuminoids,
the
bioactive
compounds
found
in
turmeric,
exhibit
potent
antioxidant,
anti-inflammatory,
and
neuroprotective
properties.
This
study
aims
to
enhance
extraction
of
curcuminoids
from
turmeric
using
environmentally
friendly
solvents
supercritical
CO2
(scCO2)
combined
with
natural
deep
eutectic
(NADESs)
one
process,
evaluate
resulting
biological
activity.
Methods:
A
Box–Behnken
statistical
design
was
applied
optimize
scCO2
conditions—pressure,
volume,
temperature—to
maximize
curcuminoid
yield.
Next,
menthol
lactic
acid
NADESs
were
selected,
these
two
into
a
single
process.
The
activity
extract
evaluated
antioxidant
assays
(ferric
reducing
power
2,2-diphenyl-1-picrylhydrazyl)
enzyme
inhibition
(acetylcholinesterase,
butyrylcholinesterase,
tyrosinase).
Toxicity
assessments
conducted
on
aquatic
invertebrates
Daphnia
pulex,
Artemia
sp.,
Chironomus
aprilinus.
Results:
most
effective
achieved
menthol–lactic
NADES
as
cosolvent,
integrated
at
1:20
ratio
plant
material
while
combination
scCO2.
optimized
scCO2–NADES
resulted
high
yield
(33.35
mg/g),
outperforming
(234.3
μg/g),
ultrasound-assisted
(30.50
alcohol-based
(22.95–26.42
mg/g).
In
assays,
demonstrated
significant
enzymes
studies
showed
concentration-dependent
response,
EC50
for
aprilinus
level
0.098
μL/mL
pulex
exhibiting
sensitivity
extract.
Conclusions:
highlights
potential
combining
demonstrating
effectiveness
maximizing
enhancing
bioactivity.
Separation Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 1 - 27
Опубликована: Янв. 15, 2025
The
sustainable
extraction
of
natural
antioxidants
from
plants
has
gained
significant
attention
as
a
viable
alternative
to
synthetic
options
in
the
food
industry.
However,
traditional
processes
often
rely
on
hazardous
solvents,
raising
concerns
about
toxicity
and
environmental
impact.
This
review
highlights
transformative
potential
green
solvents
innovative
technologies
advancing
practices
aligned
with
Sustainable
Development
Goals.
Key
findings
include
effectiveness
intensification
techniques,
such
ultrasound-assisted
microwave-assisted
extractions,
enhancing
efficiency
reducing
resource
use.
also
explores
solutions
critical
challenges
like
solvent
recovery
recycling,
promising
approaches
biphasic
systems
situ
methods
demonstrating
industrial
feasibility.
Notably,
this
work
bridges
gap
between
laboratory-scale
research
large-scale
production
by
emphasizing
strategies
improve
process
scalability.
By
synthesizing
current
trends
identifying
future
directions,
offers
unique
insights
into
commercially
for
antioxidant
extraction,
positioning
essential
tools
more
Food Chemistry X,
Год журнала:
2025,
Номер
26, С. 102273 - 102273
Опубликована: Фев. 1, 2025
Grape
seeds
are
by-products
of
vinification
process.
In
this
work,
a
green
ultrasound-assisted
extraction
grape
oil
was
performed
by
using
the
natural
volatile
deep
eutectic
solvent
(NADES)
menthol:
thymol
1:1.
The
obtained
compared
to
that
deriving
from
UAE
with
n-hexane
in
terms
fatty
acids
composition
and
biological
activities.
content
linoleic
acid
low
for
DES
extracted
oil;
linolenic
increased
0.53
%
5.18
%.
showed
best
total
phenolic
(18.65
mg
GAE/g)
flavonoid
(0.73
RE/g)
contents
highest
results
FRAP,
CUPRAC,
MCA
Phosphomolybdenum
assays.
also
higher
amylase
inhibition
(0.57
mmol
ACAE/g)
than
extract
(0.47
ACAE/g).
Finally,
anti-inflammatory
activity
assessed
vivo
through
tree
different
assays,
suggesting
their
could
be
partially
responsible
significant
effect
seed
NADES.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 601 - 601
Опубликована: Янв. 12, 2025
This
study
investigates
the
biorefinery
approach
to
extracting
blood–brain
barrier
(BBB)-permeable
compounds
from
Eucalyptus
globulus
Labill.
and
Salvia
officinalis
L.
for
neuroprotective
purposes.
A
sequential
extraction
process
was
applied,
starting
with
supercritical
CO2
(SC-CO2)
obtain
non-polar
terpenoids,
followed
by
pressurized
natural
deep
eutectic
solvent
(PLE-NaDES)
recover
phenolic
SC-CO2
residue.
PLE-NaDES
extracts
exhibited
higher
antioxidant
anticholinergic
capacities
than
both
plants,
S.
being
more
bioactive
E.
extracts.
total
of
21
terpenoids
were
identified
using
gas
chromatography–mass
spectrometry
while
24
detected
In
addition,
25
different
in
plants
high-performance
liquid
chromatography
coupled
mass
The
permeability
across
BBB
showed
limited
obtained
plants;
however,
polar
high
permeability,
particularly
flavonoids
rosmarinic
acid
officinalis.
revealed,
first
time,
potential
PLE-NaDES,
as
well
when
crossing
exert
their
protective
effects.
research
opens
a
new
pathway
exploring
alternatives
current
drugs
used
treating
neurodegenerative
diseases.
Applied Sciences,
Год журнала:
2025,
Номер
15(8), С. 4423 - 4423
Опубликована: Апрель 17, 2025
The
deterioration
of
the
Carica
papaya
L.
fruit
caused
by
Colletotrichum
gloeosporioides
highlights
importance
postharvest
packaging
for
extending
shelf
life.
To
this
end,
in
present
study,
pectin/gelatin-based
food
(FPC)
was
enriched
with
Azadirachta
indica
hydroethanolic
extract
(HNE),
obtained
pressurized
liquid
extraction
(PLE)
and
microwave-assisted
(MAE).
HNE
showed
a
high
concentration
phenolic
compounds,
values
2893
mg
GAE/100
g
3136
thickness
incorporated
(FPC
+
HNE)
did
not
significantly
differ
HNE-PLE:
0.10
±
0.01,
FPC
HNE-MAE:
0.16
0.04)
from
control
(FPC:
0.11
0.00).
Nevertheless,
exhibited
enhanced
elongation
10.33
0.2%,
9.50
0.2%)
compared
to
(8.00
0.0%).
Variations
water
vapor
permeability
5.2
g·mm/d·m2·kPa,
2.0
6.9
g·mm/d·m2·kPa)
tensile
strength
13.76
0.79
MPa,
16.45
2.25
9.24
2.01
MPa)
were
observed
among
all
samples.
HNE-PLE
resulted
0%
over
15
days.
antifungal
provides
promising
way
reduce
losses
extend
life
fruit.
Separation Science Plus,
Год журнала:
2024,
Номер
7(11)
Опубликована: Сен. 10, 2024
ABSTRACT
Honeysuckle,
a
traditional
Chinese
medicine,
holds
significant
medicinal
value,
making
it
ubiquitous
in
the
medical
field.
However,
efficient
extraction
of
chlorogenic
acid
from
herbal
medicine
while
maintaining
its
pharmacological
activity
remains
pressing
challenge.
To
address
issues
environmental
pollution
and
inefficient
using
solvents,
there
is
need
to
develop
novel
solvent.
Due
their
low
cost,
nontoxic,
environmentally
friendly
characteristics,
deep
eutectic
solvents
can
be
used
for
extracting
materials
preserving
active
ingredients
during
process.
In
this
study,
we
examined
antibacterial
acid,
key
component
honeysuckle,
after
We
gained
preliminary
insights
into
extract
against
various
bacteria,
including
Escherichia
coli
,
Staphylococcus
aureus
Pseudomonas
aeruginosa
.
Furthermore,
analyzed
extracts
different
concentrations
liquid
medium,
morphology
bacteria
inhibition
was
analyzed.
These
findings
suggest
that
solvent
(DES)
an
efficient,
friendly,
cost‐effective
method
components
honeysuckle.
Moreover,
extracted
DES
retain
robust
physiological
activity.
Molecules,
Год журнала:
2024,
Номер
30(1), С. 55 - 55
Опубликована: Дек. 27, 2024
Phenolic
compounds
present
in
plants
and
foods
are
receiving
increasing
attention
for
their
bioactive
sensory
properties,
accompanied
by
consumers’
interest
products
with
health
benefits
derived
from
natural
rather
than
artificial
sources.
This,
together
the
sustainable
development
goals
21st
century,
has
driven
of
green
extraction
techniques
that
allow
obtaining
these
safety
quality
required
to
be
applied
food,
cosmetic
pharmaceutical
industries.
Green
involves
practices
aiming
at
reducing
environmental
impact
preparation
processes,
based
on
using
or
less-polluting
solvents,
lower
energetic
requirements
shorter
times,
while
providing
greater
efficiency
recovery
target
compounds.
In
this
article,
principles
advances
produced
recent
years
regarding
isolation
polyphenols
plants,
food
waste
reviewed.
