Longitudinal associations of lipid profiles with sleep disorders in patients with Parkinson's disease DOI Open Access
Meijie Ye, Qianqian Ji, Qi Liu

и другие.

Lipids, Год журнала: 2024, Номер 60(3), С. 115 - 123

Опубликована: Дек. 19, 2024

To examine the associations of apolipoprotein E (APOE) carrier status and lipid profiles with sleep disorders, including excessive daytime sleepiness (EDS) probable rapid eye movement behavior disorder (pRBD), among patients early Parkinson's disease (PD) over 5-year follow-up periods. The Progression Markers Initiative is a multicenter cohort study based on an ongoing open-ended registry. Data from baseline visits participants de novo PD were analyzed. Longitudinal APOE disorders estimated via linear mixed-effects models. A total 657 complete genotypes enrolled at baseline. Among them, 153 (25.3%) had available In models, ε2/ε3/ε4 did not exhibit significant EDS pRBD (all p > 0.05) in all However, reduced high-density lipoprotein (HDL) elevated triglycerides (TG) associated developing (β = -0.04, 95% CI: -0.07, -0.00) 0.01, 0.00, 0.02) patients, respectively. ε4+ subgroup, decreased HDL increased TG displayed substantial < respectively, whereas no differences noted ε4- subgroup 0.05). Our demonstrate clear association between patients. presence ε4 was changes profiles, notably affecting levels.

Язык: Английский

Differential striatal dopamine binding in Parkinson’s Disease with and without REM sleep behavior disorder: A Tc-99 m TRODAT-1 SPECT study DOI

Pei-Hsuan Wang,

Yang‐Pei Chang, Ching‐Fang Chien

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Язык: Английский

Процитировано

0
The Tasmania-London (TASLON) 3-step home-based video-polysomnography approach to detect iRBD in the community: protocol and preliminary results DOI
Samantha Bramich, Alastair Noyce, Anna E. King

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Abstract Study Objective: Isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is an early manifestation of alpha-synuclein-related neurodegenerative diseases (NDD). There average delay in iRBD diagnosis 9 years showing that we need easier methods detection to improve access specialist care and disease modifying clinical trials. We designed a 3-step approach detect community older adults (>50years) Tasmania, Australia using home-based video-polysomnography (vPSG). Methods: The Tasmania-London (TASLON) protocol comprised 3 steps: participants completed online screening question; those who screened positive were invited undertake the TASLON Screening Interview by telephone; sample then vPSG based on risk level. Results: A total 2891 (mean [SD] age 64 [7.7] years; 26% male) without any known NDD recruited from throughout Tasmania. 267 (9%; 63[7.7] 45% identified as having ‘probable’ RBD through screening; 85 (32%) agreed complete interview; 48 (56%) underwent vPSG; 21(44%; 68[7] 48% found have iRBD. Conclusion: feasible method improving timely diagnoses community. It streamlines path identifying at highest iRBD, thus diagnostic testing trial opportunities for otherwise may not been identified.

Язык: Английский

Процитировано

0
Longitudinal associations of lipid profiles with sleep disorders in patients with Parkinson's disease DOI Open Access
Meijie Ye, Qianqian Ji, Qi Liu

и другие.

Lipids, Год журнала: 2024, Номер 60(3), С. 115 - 123

Опубликована: Дек. 19, 2024

To examine the associations of apolipoprotein E (APOE) carrier status and lipid profiles with sleep disorders, including excessive daytime sleepiness (EDS) probable rapid eye movement behavior disorder (pRBD), among patients early Parkinson's disease (PD) over 5-year follow-up periods. The Progression Markers Initiative is a multicenter cohort study based on an ongoing open-ended registry. Data from baseline visits participants de novo PD were analyzed. Longitudinal APOE disorders estimated via linear mixed-effects models. A total 657 complete genotypes enrolled at baseline. Among them, 153 (25.3%) had available In models, ε2/ε3/ε4 did not exhibit significant EDS pRBD (all p > 0.05) in all However, reduced high-density lipoprotein (HDL) elevated triglycerides (TG) associated developing (β = -0.04, 95% CI: -0.07, -0.00) 0.01, 0.00, 0.02) patients, respectively. ε4+ subgroup, decreased HDL increased TG displayed substantial < respectively, whereas no differences noted ε4- subgroup 0.05). Our demonstrate clear association between patients. presence ε4 was changes profiles, notably affecting levels.

Язык: Английский

Процитировано

0