Lipidome Alterations of Prefrontal Cortex and Hippocampus of Mice‐Induced Sleep Deprivation

ChemistrySelect, Год журнала: 2025, Номер 10(8)

Опубликована: Фев. 1, 2025

Abstract Chronic sleep deprivation (SD) impairscognitive function and promotes neurodegenerative changes, particularly in thehippocampus prefrontal cortex. Study investigates the biochemical andimmunological effects of SD evaluates neuroprotective properties ofmelatonin using Fourier Transform Raman (FT‐Raman) spectroscopy. Hippocampaland cortical tissues from four groups micecontrol, melatonin‐treated, sleep‐deprived, sleep‐deprived with melatoninwere analyzed. FT‐Ramanspectra revealed significant changes C─H bending, C─C vibrations, amides, lipids between control groups. led to increased lipidperoxidation, especially hippocampus, while melatonin treatment reducedlipid peroxidation amide levels. In cortex, mitigatedbiochemical alterations associated SD, such as elevated amides lipids.Immunological assessments showed SD‐induced T helper (Th) cellsubpopulations, including an increase effector Th cells a decrease innaive cells. Melatonin normalized these changes. PrincipalComponent Analysis (PCA) indicated clear separation SDsamples, PC1 PC2 explaining 95.58% variance. Classificationusing GS‐kNN algorithm achieved cortex (accuracies: 79.167%) andin hippocampus 70.833%). These findings highlight SD‐inducedbiochemical immunological suggest melatonin'sneuroprotective role reducing oxidative stress modulating immunedysfunction.

Язык: Английский

Modular network analysis of abnormal functional connectivity and disrupted brain topology caused by sleep deprivation and its association with cognitive function

Sleep Medicine, Год журнала: 2025, Номер unknown, С. 106514 - 106514

Опубликована: Апрель 1, 2025

Язык: Английский

Mapping the Lung-Brain Axis: Causal Relationships Between Brain Network Connectivity and Respiratory Disorders

Brain Research Bulletin, Год журнала: 2025, Номер 227, С. 111402 - 111402

Опубликована: Май 21, 2025

Язык: Английский