Lipidome Alterations of Prefrontal Cortex and Hippocampus of Mice‐Induced Sleep Deprivation

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(8)

Published: Feb. 1, 2025

Abstract Chronic sleep deprivation (SD) impairscognitive function and promotes neurodegenerative changes, particularly in thehippocampus prefrontal cortex. Study investigates the biochemical andimmunological effects of SD evaluates neuroprotective properties ofmelatonin using Fourier Transform Raman (FT‐Raman) spectroscopy. Hippocampaland cortical tissues from four groups micecontrol, melatonin‐treated, sleep‐deprived, sleep‐deprived with melatoninwere analyzed. FT‐Ramanspectra revealed significant changes C─H bending, C─C vibrations, amides, lipids between control groups. led to increased lipidperoxidation, especially hippocampus, while melatonin treatment reducedlipid peroxidation amide levels. In cortex, mitigatedbiochemical alterations associated SD, such as elevated amides lipids.Immunological assessments showed SD‐induced T helper (Th) cellsubpopulations, including an increase effector Th cells a decrease innaive cells. Melatonin normalized these changes. PrincipalComponent Analysis (PCA) indicated clear separation SDsamples, PC1 PC2 explaining 95.58% variance. Classificationusing GS‐kNN algorithm achieved cortex (accuracies: 79.167%) andin hippocampus 70.833%). These findings highlight SD‐inducedbiochemical immunological suggest melatonin'sneuroprotective role reducing oxidative stress modulating immunedysfunction.

Language: Английский

Modular network analysis of abnormal functional connectivity and disrupted brain topology caused by sleep deprivation and its association with cognitive function

Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 106514 - 106514

Published: April 1, 2025

Language: Английский

Mapping the Lung-Brain Axis: Causal Relationships Between Brain Network Connectivity and Respiratory Disorders

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 227, P. 111402 - 111402

Published: May 21, 2025

Language: Английский