Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 9, 2023
Acute
kidney
injury
(AKI)
is
a
clinical
syndrome
that
results
from
rapid
decline
in
renal
structure
or
functional
impairment
with
the
main
pathological
feature
of
sublethal
and
lethal
damage
to
tubular
cells.
However,
many
potential
therapeutic
agents
cannot
achieve
desired
effect
because
their
poor
pharmacokinetics
short
retention
time
kidneys.
With
recent
emergence
progress
nanotechnology,
nanodrugs
unique
physicochemical
properties
could
prolong
circulation
time,
enhance
efficient
targeted
delivery,
elevate
accumulation
therapeutics
can
cross
glomerular
filtration
barrier
indicate
comprehensive
application
prospects
prevention
treatment
AKI.
In
this
review,
various
types
nanosystems
(such
as
liposomes,
polymeric
nanosystems,
inorganic
nanoparticles
cell-derived
extracellular
vesicles)
are
designed
applied
improve
drug
formation,
which
further
relieve
burden
on
kidneys
caused
by
final
cumulative
dose
drugs
conventional
treatments.
Moreover,
passive
active
targeting
also
reduce
total
off-target
adverse
effects
other
organs.
Nanodelivery
systems
for
treating
AKI
alleviate
oxidative
stress-induced
cell
regulate
inflammatory
microenvironment
summarized.
Regenerative Biomaterials,
Год журнала:
2023,
Номер
10
Опубликована: Янв. 1, 2023
Bone
defects
are
a
persistent
challenge
in
clinical
practice.
Although
repair
therapies
based
on
tissue-engineered
materials,
which
known
to
have
crucial
role
defective
bone
regeneration,
gathered
increased
attention,
the
current
treatments
for
massive
several
limitations.
In
present
study,
immunomodulatory
inflammatory
microenvironment
properties
of
quercetin,
we
encapsulated
quercetin-solid
lipid
nanoparticles
(SLNs)
hydrogel.
Temperature-responsive
poly(ε-caprolactone-co-lactide)-b-poly(ethylene
glycol)-b-poly(ε-caprolactone-co-lactide)
modifications
were
coupled
main
chain
hyaluronic
acid
hydrogel,
constructing
novel,
injectable
hydrogel
scaffold.
Extensive
Smart Materials in Medicine,
Год журнала:
2023,
Номер
4, С. 578 - 589
Опубликована: Янв. 1, 2023
Mesenchymal
stem
cell
exosomes
(MSC-Exos)
are
a
type
of
vesicle
with
biological
function
secreted
by
mesenchymal
cells
(MSCs).
In
tissue
repair,
MSC-Exos
more
effective
than
MSCs,
and
they
can
be
used
as
cell-free
alternative
therapy
to
MSCs.
This
therapeutic
system
has
stable
membrane
structure
that
is
coated
proteins,
miRNAs,
mRNA,
lncRNA,
DNA,
other
macromolecular
active
substances.
These
molecules
have
powerful
effect
on
regeneration.
regulate
the
target
through
direct
recognition,
fusion,
secretion
communication
mediators.
Skin
wound
healing
consists
mainly
blood
coagulation,
inflammation
response,
proliferation,
remodeling.
By
regulating
four
stages
healing,
effectively
reduce
inflammation,
immune
promote
enhanced
migration
angiogenesis
remodeling,
thus
shortening
time
reducing
scar
formation.
A
variety
factors,
genetic
material
signaling
pathways
involved
in
this
process.
article
reviews
efficacy
mechanism
promoting
skin
repair.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Май 1, 2024
The
need
for
tumor
postoperative
treatments
aimed
at
recurrence
prevention
and
tissue
regeneration
have
raised
wide
considerations
in
the
context
of
design
functionalization
implants.
Herein,
an
injectable
hydrogel
system
encapsulated
with
anti-tumor,
anti-oxidant
dual
functional
nanoparticles
has
been
developed
order
to
prevent
relapse
after
surgery
promote
wound
repair.
utilization
biocompatible
gelatin
methacryloyl
(GelMA)
was
geared
towards
localized
therapeutic
intervention.
Zeolitic
imidazolate
framework-8@ceric
oxide
(ZIF-8@CeO2,
ZC)
(NPs)
were
purposefully
devised
their
proficiency
as
reactive
oxygen
species
(ROS)
scavengers.
Furthermore,
GelMA
hydrogels
loaded
ZC
NPs
carrying
doxorubicin
(ZC-DOX@GEL)
tailored
multifunctional
implants,
ensuring
efficacious
eradication
residual
cells
alleviation
oxidative
stress.
In
vitro
vivo
experiments
conducted
substantiate
efficacy
cancer
cell
elimination
through
synergistic
chemotherapy
approach
employed
ZC-DOX@GEL.
acceleration
ROS
scavenging
attributes
ZC@GEL
corroborated
using
rat
models
healing.
results
underscore
potential
multifaceted
presented
herein
promising
application
treatments.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 9, 2023
Acute
kidney
injury
(AKI)
is
a
clinical
syndrome
that
results
from
rapid
decline
in
renal
structure
or
functional
impairment
with
the
main
pathological
feature
of
sublethal
and
lethal
damage
to
tubular
cells.
However,
many
potential
therapeutic
agents
cannot
achieve
desired
effect
because
their
poor
pharmacokinetics
short
retention
time
kidneys.
With
recent
emergence
progress
nanotechnology,
nanodrugs
unique
physicochemical
properties
could
prolong
circulation
time,
enhance
efficient
targeted
delivery,
elevate
accumulation
therapeutics
can
cross
glomerular
filtration
barrier
indicate
comprehensive
application
prospects
prevention
treatment
AKI.
In
this
review,
various
types
nanosystems
(such
as
liposomes,
polymeric
nanosystems,
inorganic
nanoparticles
cell-derived
extracellular
vesicles)
are
designed
applied
improve
drug
formation,
which
further
relieve
burden
on
kidneys
caused
by
final
cumulative
dose
drugs
conventional
treatments.
Moreover,
passive
active
targeting
also
reduce
total
off-target
adverse
effects
other
organs.
Nanodelivery
systems
for
treating
AKI
alleviate
oxidative
stress-induced
cell
regulate
inflammatory
microenvironment
summarized.
