Current Stem Cell Research & Therapy,
Год журнала:
2023,
Номер
19(8), С. 1084 - 1092
Опубликована: Окт. 11, 2023
Abstract::
Wound
infection
often
requires
a
long
period
of
care
and
an
onerous
treatment
process.
Also,
the
rich
environment
makes
wound
ideal
niche
for
microbial
growth.
Stable
structures,
like
biofilm,
drug-resistant
strains
cause
delay
in
healing
process,
which
has
become
one
important
challenges
treatment.
Many
studies
have
focused
on
alternative
methods
to
deal
infections.
One
novel
highly
potential
ways
is
mesenchymal
stromal
cells
(MSCs).
MSCs
are
mesoderm-derived
pluripotent
adult
stem
with
capacity
self-renewal,
multidirectional
differentiation,
immunological
control.
anti-inflammatory
antiapoptotic
effects.
MScs,
as
cells,
differentiate
into
many
mature
cells.
produce
antimicrobial
compounds,
such
peptides
(AMP),
well
secrete
immune
modulators,
two
basic
features
considered
healing.
Despite
advantages,
preserving
structure
activity
most
points
MSCs’
effects
microorganisms
involved
been
confirmed
various
studies.
In
this
review,
we
aimed
discuss
therapeutic
applications
infected
processes.
Abstract
The
healing
process
at
a
wound
is
made
up
of
many
types
cells,
growth
factors,
the
extracellular
matrix,
nerves
and
blood
vessels
all
interacting
with
each
other
in
complex
changing
ways.
Microbial
colonization
proliferation
are
possible
place
injury,
which
makes
infection
more
likely.
Because
this,
any
cut
has
chance
getting
an
infection.
Researchers
have
found
that
infections
make
patients
upset
cost
healthcare
system
lot
money.
Surgical
site
happen
to
people
who
recently
had
surgery.
This
study
shows
such
surgical
linked
high
rate
illness
death.
shown
by
fact
25%
get
serious
sepsis
need
be
transferred
intensive
care
unit.
In
both
animal
models
people,
mesenchymal
stem
cells
(MSCs)
play
active
role
stages
positive
effects.
Exosomes
one
main
things
MSCs
release.
They
effects
similar
those
parent
MSCs.
Various
effector
proteins,
messenger
RNA
microRNAs
can
transported
vesicles
control
activity
target
cells.
big
impact
on
process.
These
results
suggest
using
MSC-exosomes
as
new
type
cell-free
therapy
could
better
safer
option
than
whole
cell
therapy.
review
mostly
about
how
use
parts
help
heal.
Nano TransMed,
Год журнала:
2023,
Номер
2(2-3), С. 100004 - 100004
Опубликована: Сен. 1, 2023
Extracellular
vesicles
(EVs),
which
are
natural
nanocarriers
characterized
by
a
phospholipid
bilayer
structure,
released
living
cells.
They
play
crucial
role
in
the
intercellular
transport
of
proteins,
nucleic
acids,
lipids,
and
metabolites,
facilitating
substance
delivery
information
exchange
between
In
light
recent
numerous
studies,
EVs
has
been
found
to
transcend
their
basic
as
mere
vehicle.
Instead,
they
demonstrate
an
impressive
array
biological
activities,
displaying
preventive
therapeutic
potential
mitigating
various
pathological
processes
encompassing
cancer,
neoplastic
proliferation,
infectious
diseases,
oxidative
trauma.
Particularly,
derived
from
edible
plants
(EPDEVs)
have
emphasized
for
extensive
range
physiological
regulatory
functions
animals
humans,
with
targeted
drug
through
oral
administration.
Leveraging
these
advantages,
EPDEVs
expected
excellent
competitiveness
clinical
applications
or
healthcare
products.
This
review
provides
brief
overview
biogenesis,
composition
EPDEVs,
summarizes
mechanisms.
It
also
analyzes
methods
isolating
purifying
plant-EVs,
assessing
advantages
disadvantages;
discusses
latest
advancements
biomedical
applications,
concludes
prospective
insight
into
research
development
directions
EPDEVs.
Abstract
Extracellular
vesicles
(EVs)
are
heterogeneous
membrane-like
secreted
by
living
cells
that
involved
in
many
physiological
and
pathological
processes
act
as
intermediaries
of
intercellular
communication
molecular
transfer.
Recent
studies
have
shown
EVs
from
specific
sources
regulate
tissue
repair
regeneration
delivering
proteins,
lipids,
nucleic
acids
to
target
signaling
molecules.
Nanotechnology
breakthroughs
facilitated
the
development
exploration
engineered
for
repair.
Enhancements
through
gene
editing,
surface
modification,
content
modification
further
improved
their
therapeutic
efficacy.
This
review
summarizes
potential
regeneration,
mechanisms
action,
research
progress
regenerative
medicine.
highlights
design
logic
typical
examples
explores
prospects
The
aim
this
is
provide
new
insights
into
applications,
thereby
expanding
use
Abstract
Effective
wound
management
and
treatment
are
crucial
in
clinical
practice,
yet
existing
strategies
often
fall
short
fully
addressing
the
complexities
of
skin
healing.
Recent
advancements
tissue
engineering
have
introduced
innovative
approaches,
particularly
through
use
nanobiomaterials,
to
enhance
healing
process.
In
this
context,
titanium
dioxide
nanoparticles
(TiO2
NPs)
garnered
attention
due
their
excellent
biological
properties,
including
antioxidant,
anti-inflammatory,
antimicrobial
properties.
Furthermore,
these
can
be
modified
therapeutic
benefits.
Scaffolds
dressings
containing
TiO2
NPs
demonstrated
promising
outcomes
accelerating
enhancing
regeneration.
This
review
paper
covers
process,
properties
that
make
them
suitable
for
promoting
healing,
methods
synthesizing
NPs,
scaffolds
application
potential
toxicity
NPs.
Journal of Cosmetic Dermatology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Background
Exosomes
are
a
nanoscale
extracellular
vesicles
derived
from
different
cell
types
that
have
been
investigated
for
various
clinical
applications,
including
functioning
as
biomarkers
and
use
direct
therapeutics.
Given
the
role
of
exosomes
in
multiple
pathophysiologic
pathways
potential
practical
they
garnered
significant
interest
scientific
community
but
much
is
still
unknown
about
their
development
use.
Aims
This
literature
review
covers
background,
mechanisms
action,
biomarkers,
methods
application,
therapeutic
applications
exosomes.
Methods
A
on
background
uses
was
conducted.
Key
articles
describing
were
summarized
described.
Results
impact
several
cellular
which
allow
them
to
function
malignancy
inflammatory
dermatoses
may
make
useful
therapeutics
skin
rejuvenation,
hair
loss,
wound
repair.
Limitations
include
an
incomplete
understanding
functions
impacts
lack
standardization
production
application.
Conclusions
unique
novel
medium
offer
promise
diagnostic
tool
therapy.
While
there
limitations
well
our
current
them,
further
investigation
yield
additional
larger
medicine
