Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Myocardial
infarction
(MI)
is
a
prevalent
disease
with
high
mortality
rates
worldwide.
The
course
of
MI
intricate
and
variable,
necessitating
personalized
treatment
strategies
based
on
different
mechanisms.
However,
variety
postoperative
complications
rejections,
such
as
heart
failure,
arrhythmias,
cardiac
rupture,
left
ventricular
thrombus,
contribute
to
poor
prognosis.
Despite
the
inclusion
antiplatelet
agents
statins
in
conventional
regimen,
their
clinical
applicability
constrained
by
potential
adverse
effects
limited
efficacy.
Additionally,
mechanisms
leading
are
complex
diverse.
Therefore,
development
novel
compounds
for
treatment.
use
traditional
Chinese
medicine
(TCM)
prevention
cardiovascular
diseases,
including
MI,
grounded
its
profound
historical
background,
comprehensive
theoretical
system,
accumulated
knowledge.
An
increasing
number
contemporary
evidence-based
medical
studies
have
demonstrated
that
TCM
plays
significant
role
alleviating
symptoms
improving
quality
life
patients.
herbal
formulations
active
ingredients
can
intervene
pathological
process
through
key
factors
inflammation,
oxidative
stress,
apoptosis,
ferroptosis,
pyroptosis,
myocardial
fibrosis,
angiogenesis,
autophagy.
This
article
critically
reviews
existing
from
an
perspective,
evaluating
research
status
applications.
it
explores
recent
advancements
medicines
components
offering
detailed
insights
into
action.
International Journal of Biological Sciences,
Год журнала:
2024,
Номер
20(5), С. 1871 - 1883
Опубликована: Янв. 1, 2024
Radiotherapy
(RT)
stands
as
the
primary
treatment
for
tumors,
but
it
inevitably
causes
damage
to
normal
cells.Consequently,
radiation
injury
is
a
crucial
consideration
oncologists
during
therapy
planning.Cell
death
including
apoptosis,
autophagy,
pyroptosis,
ferroptosis,
and
necroptosis
play
significant
roles
in
tumor
treatment.While
previous
studies
elucidated
induction
of
apoptosis
autophagy
by
ionizing
(IR),
recent
attention
has
shifted
necroptosis,
revealing
their
effects
induced
IR.This
review
aims
summarize
strategies
employed
IR,
either
alone
or
combination
therapy,
induce
injury.Furthermore,
we
explore
molecular
pathways,
shedding
light
on
injury.Finally,
regulative
agents
these
three
types
cell
mechanisms.In
summary,
optimizing
dose,
dose
rate,
combined
plans
minimize
enhance
killing
effect
RT
key
focus.
Abstract
In
multicellular
organisms,
regulatory
cell
death
is
a
crucial
aspect
of
growth
and
development.
Ferroptosis,
which
was
postulated
roughly
ten
years
ago,
mode
that
differs
from
apoptosis,
autophagy,
pyrodeath.
This
distinct
pattern
triggered
by
an
imbalance
between
oxidants
antioxidants
strongly
associated
with
the
metabolism
iron,
lipids,
amino
acids,
glutathione.
A
growing
body
research
has
implicated
ferroptosis
in
incidence
progression
many
organ
traumas
degenerative
diseases.
Recently,
gained
attention
as
mechanism
underlying
initiation
development
variety
cardiovascular
diseases,
including
myocardial
ischemia/reperfusion
injury,
cardiomyopathy,
arrhythmia,
chemotherapy,
Corona
Virus-2-induced
cardiac
injury.
Pharmacological
therapies
inhibit
have
great
potential
for
management
disorders.
review
discusses
prevalence
mechanisms
ferroptosis,
effect
on
immune
system,
significance
therapeutic
value
regulating
heart
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 3839 - 3864
Опубликована: Июнь 1, 2024
Pyroptosis
is
a
pro-inflammatory
form
of
cell
death
resulting
from
the
activation
gasdermins
(GSDMs)
pore-forming
proteins
and
release
several
factors.
However,
inflammasomes
are
intracellular
protein
complexes
that
cleave
gasdermin
D
(GSDMD),
leading
to
formation
robust
membrane
pores
initiation
pyroptosis.
Inflammasome
gasdermin-mediated
pore
important
intrinsic
processes
in
classical
pyroptotic
signaling
pathway.
Overactivation
NOD-like
receptor
thermal
domain
associated
3
(NLRP3)
inflammasome
triggers
pyroptosis
amplifies
inflammation.
Current
evidence
suggests
overactivation
may
further
induce
progression
cancers,
nerve
injury,
inflammatory
disorders
metabolic
dysfunctions.
also
indicates
pyroptosis-dependent
accelerates
diabetes
its
frequent
consequences
including
diabetic
peripheral
neuropathy
(DPN).
Pyroptosis-mediated
reaction
exacerbates
DPN-mediated
CNS
injury.
Accumulating
shows
molecular
mechanisms
trigger
insulin-producing
cells,
development
DPN.
Numerous
studies
have
suggested
certain
natural
compounds
or
drugs
possess
promising
pharmacological
properties
by
modulating
pyroptosis,
thereby
offering
potential
preventive
practical
therapeutic
approaches
for
treatment
management
This
review
elaborates
on
underlying
explores
possible
strategies
regulating
pyroptosis-regulated
Molecules,
Год журнала:
2023,
Номер
28(23), С. 7813 - 7813
Опубликована: Ноя. 28, 2023
Diabetic
cardiomyopathy
(DCM)
is
a
pathophysiological
condition
triggered
by
diabetes
mellitus
(DM),
which
can
lead
to
heart
failure
(HF).
One
of
the
most
important
cellular
processes
associated
with
DCM
death
cardiomyocytes.
Gasdermin
D
(GSDMD)
plays
key
role
in
mediating
pyroptosis,
type
programmed
cell
closely
inflammasome
activation.
Recent
studies
have
revealed
that
pyroptosis
induced
during
hyperglycemia,
crucial
development
DCM.
Although
effects
on
been
discussed,
relationship
between
and
GSDMD
not
fully
clarified.
gave
us
impetus
for
clarifying
meaning
The
purpose
this
review
summarize
new
emerging
insights,
mainly
discussing
structures
mechanism
pore
formation,
activation
pathways,
molecular
mechanisms
GSDMD-mediated
therapeutic
potential
implications
will
pave
way
target
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117367 - 117367
Опубликована: Авг. 29, 2024
The
pyroptosis
of
cardiomyocytes
has
become
an
essential
topic
in
heart
failure
research.
abnormal
accumulation
these
biological
factors,
including
angiotensin
II,
advanced
glycation
end
products,
and
various
growth
factors
(such
as
connective
tissue
factor,
vascular
endothelial
transforming
factor
beta,
among
others),
activates
the
nuclear
factor-κB
(NF-κB)
signaling
pathway
cardiovascular
diseases,
ultimately
leading
to
cardiomyocytes.
Therefore,
exploring
underlying
molecular
mechanisms
is
for
developing
novel
drugs
therapeutic
strategies.
However,
our
current
understanding
precise
regulatory
mechanism
this
complex
cardiomyocyte
still
limited.
Given
this,
study
reviews
milestone
discoveries
field
research
since
1986,
analyzes
detail
similarities,
differences,
interactions
between
other
cell
death
modes
apoptosis,
necroptosis,
autophagy,
ferroptosis),
explores
deep
connection
failure.
At
same
time,
it
depicts
complete
activation,
transmission,
eventual
NF-κB
process
In
addition,
also
systematically
summarizes
approaches
that
can
inhibit
reduce
pyroptosis,
drugs,
natural
compounds,
small
molecule
inhibitors,
gene
editing,
cutting-edge
technologies,
aiming
provide
solid
scientific
support
new
perspectives
prevention
treatment
Acta Biochimica et Biophysica Sinica,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Pyroptosis
is
a
regulated
inflammatory
cell
death
process
that
plays
an
essential
role
in
various
diseases.
This
study
investigates
the
of
proline/serine-rich
coiled-coil
protein
1
(PSRC1)
pyroptosis
and
inflammation
macrophages.
reports
PSRC1
expression
decreased
pyroptotic
macrophages
knockout
PSRC1
exacerbates
inflammation.
overexpression
alleviates
RNA-seq
analysis
reveals
regulates
genes
involved
extracellular
matrix
(ECM).
Specifically,
downregulates
periostin
(POSTN),
ECM
component.
Knockdown
POSTN
suppresses
macrophage
mediated
by
low
PSRC1.
These
findings
suggest
can
alleviate
bone
marrow-derived
(BMDMs)
regulating
negatively
POSTN.
provides
insights
into
identifies
potential
target
for
treatment
Further
research
needed
to
confirm
these
in
vivo
disease
models.
