Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
Myocardial
infarction
(MI)
is
a
prevalent
disease
with
high
mortality
rates
worldwide.
The
course
of
MI
intricate
and
variable,
necessitating
personalized
treatment
strategies
based
on
different
mechanisms.
However,
variety
postoperative
complications
rejections,
such
as
heart
failure,
arrhythmias,
cardiac
rupture,
left
ventricular
thrombus,
contribute
to
poor
prognosis.
Despite
the
inclusion
antiplatelet
agents
statins
in
conventional
regimen,
their
clinical
applicability
constrained
by
potential
adverse
effects
limited
efficacy.
Additionally,
mechanisms
leading
are
complex
diverse.
Therefore,
development
novel
compounds
for
treatment.
use
traditional
Chinese
medicine
(TCM)
prevention
cardiovascular
diseases,
including
MI,
grounded
its
profound
historical
background,
comprehensive
theoretical
system,
accumulated
knowledge.
An
increasing
number
contemporary
evidence-based
medical
studies
have
demonstrated
that
TCM
plays
significant
role
alleviating
symptoms
improving
quality
life
patients.
herbal
formulations
active
ingredients
can
intervene
pathological
process
through
key
factors
inflammation,
oxidative
stress,
apoptosis,
ferroptosis,
pyroptosis,
myocardial
fibrosis,
angiogenesis,
autophagy.
This
article
critically
reviews
existing
from
an
perspective,
evaluating
research
status
applications.
it
explores
recent
advancements
medicines
components
offering
detailed
insights
into
action.
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(5), P. 1871 - 1883
Published: Jan. 1, 2024
Radiotherapy
(RT)
stands
as
the
primary
treatment
for
tumors,
but
it
inevitably
causes
damage
to
normal
cells.Consequently,
radiation
injury
is
a
crucial
consideration
oncologists
during
therapy
planning.Cell
death
including
apoptosis,
autophagy,
pyroptosis,
ferroptosis,
and
necroptosis
play
significant
roles
in
tumor
treatment.While
previous
studies
elucidated
induction
of
apoptosis
autophagy
by
ionizing
(IR),
recent
attention
has
shifted
necroptosis,
revealing
their
effects
induced
IR.This
review
aims
summarize
strategies
employed
IR,
either
alone
or
combination
therapy,
induce
injury.Furthermore,
we
explore
molecular
pathways,
shedding
light
on
injury.Finally,
regulative
agents
these
three
types
cell
mechanisms.In
summary,
optimizing
dose,
dose
rate,
combined
plans
minimize
enhance
killing
effect
RT
key
focus.
Cell & Bioscience,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Dec. 15, 2023
Abstract
In
multicellular
organisms,
regulatory
cell
death
is
a
crucial
aspect
of
growth
and
development.
Ferroptosis,
which
was
postulated
roughly
ten
years
ago,
mode
that
differs
from
apoptosis,
autophagy,
pyrodeath.
This
distinct
pattern
triggered
by
an
imbalance
between
oxidants
antioxidants
strongly
associated
with
the
metabolism
iron,
lipids,
amino
acids,
glutathione.
A
growing
body
research
has
implicated
ferroptosis
in
incidence
progression
many
organ
traumas
degenerative
diseases.
Recently,
gained
attention
as
mechanism
underlying
initiation
development
variety
cardiovascular
diseases,
including
myocardial
ischemia/reperfusion
injury,
cardiomyopathy,
arrhythmia,
chemotherapy,
Corona
Virus-2-induced
cardiac
injury.
Pharmacological
therapies
inhibit
have
great
potential
for
management
disorders.
review
discusses
prevalence
mechanisms
ferroptosis,
effect
on
immune
system,
significance
therapeutic
value
regulating
heart
Acta Biochimica et Biophysica Sinica,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Pyroptosis
is
a
regulated
inflammatory
cell
death
process
that
plays
an
essential
role
in
various
diseases.
This
study
investigates
the
of
proline/serine-rich
coiled-coil
protein
1
(PSRC1)
pyroptosis
and
inflammation
macrophages.
reports
PSRC1
expression
decreased
pyroptotic
macrophages
knockout
PSRC1
exacerbates
inflammation.
overexpression
alleviates
RNA-seq
analysis
reveals
regulates
genes
involved
extracellular
matrix
(ECM).
Specifically,
downregulates
periostin
(POSTN),
ECM
component.
Knockdown
POSTN
suppresses
macrophage
mediated
by
low
PSRC1.
These
findings
suggest
can
alleviate
bone
marrow-derived
(BMDMs)
regulating
negatively
POSTN.
provides
insights
into
identifies
potential
target
for
treatment
Further
research
needed
to
confirm
these
in
vivo
disease
models.
Journal of Cellular and Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
29(3)
Published: Feb. 1, 2025
ABSTRACT
Ischaemic
heart
disease
(IHD)
remains
a
leading
cause
of
global
morbidity
and
mortality.
One
significant
contributor
to
the
pathology
IHD
is
excessive
release
inflammatory
mediators
during
progression.
Pyroptosis
form
programmed
cell
death
(PCD)
triggered
by
activation
inflammasomes
caspase
1.
The
1
proteolytically
cleaves
gasdermin
D
(GSDMD)
activated
amino
acid
terminus
(GSDMD‐NT),
disruption
plasma
membrane.
This
cascade
events
considered
canonical
pathway
pyroptosis.
also
caused
oxidative
stress,
thereby
triggering
noncanonical
pyroptosis
via
caspases
4/5/11.
Previous
studies
have
provided
compelling
evidence
close
relationship
between
aetiology
(e.g.,
acute
myocardial
infarction,
ischaemia
reperfusion
injury
chronic
infarction),
as
well
association
with
unfavourable
clinical
outcomes.
Several
interventions
aimed
at
targeting
demonstrated
promising
therapeutic
benefits
against
IHD‐related
pathologies.
review
provides
mechanistic
insights
into
roles
in
from
vitro,
vivo
perspectives.
In‐depth
understanding
this
area
could
pave
way
for
future
development
novel
strategies
IHD.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(3), P. 303 - 303
Published: Feb. 22, 2025
Objective:
To
investigate
the
effect
and
underlying
mechanism
of
α-cyperone
in
inhibiting
pyroptosis
rat
aortic
endothelial
cells
(RAECs).
Methods:
Molecular
docking
technology
was
used
to
predict
potential
binding
affinity
pyroptosis-related
proteins.
A
model
established
RAECs
using
serum
containing
10%
LPS,
with
administered
as
a
preventive
treatment
for
9
h.
Cell
viability
membrane
integrity
were
assessed
propidium
iodide
(PI)
staining
CCK-8
assay.
The
release
IL-1β
IL-18
quantified
by
ELISA.
Western
blot
RT-qPCR
performed
evaluate
expression
levels
NLRP3,
ASC,
caspase-1
p20,
N-GSDMD.
Additionally,
RNA
sequencing
analysis
conducted
identify
differentially
expressed
genes
related
LPS-induced
following
treatment,
key
differential
validated
blot.
Results:
reveals
that
exhibits
strong
targets.
α-Cyperone
significantly
improves
cell
(p
<
0.001),
reduces
downregulates
mRNA
protein
caspase-1,
GSDMD
0.001).
indicates
primarily
modulates
gene
through
PI3K/AKT
signaling
pathway.
validation
further
confirmed
effectively
inhibited
phosphorylated
total
PI3K
AKT
Conclusions:
alleviates
morphological
damage
RAEC
model,
suppresses
proinflammatory
cytokines
IL-18,
potentially
inhibits
NLRP3/caspase-1/GSDMD
activation
pathway,
thereby
attenuating
RAECs.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(3), P. 141 - 141
Published: Feb. 22, 2025
Cerebral
ischemia-reperfusion
injury
(CIRI)
is
a
complex
pathological
process
triggered
by
transient
obstruction
of
blood
flow
and
subsequent
reperfusion,
ultimately
leading
to
intracellular
disturbances
such
as
oxidative
stress,
inflammatory
responses,
programmed
cell
death.
Among
the
various
types
death,
pyroptosis
(an
kind
regulated
death)
has
received
increasing
attention
due
its
involvement
in
key
neurovascular
unit
cells,
including
endothelial
neurons,
microglia,
astrocytes.
Intriguingly,
accumulating
evidence
demonstrates
that
non-coding
RNAs
(ncRNAs),
long
RNAs,
microRNAs,
circular
can
modulate
multiple
stages
CIRI.
This
review
synthesizes
recent
findings
on
ncRNAs-regulated
We
highlight
molecular
underpinnings
pyroptotic
activation
following
ischemic
discuss
how
ncRNAs
shape
these
mechanisms.
By
elucidating
interactions
between
pyroptosis-related
pathways,
we
intend
present
innovative
viewpoints
for
early
diagnosis
development
potential
therapeutic
strategies
mitigate
