Central sleep apnoea: not just one phenotype

European Respiratory Review, Год журнала: 2024, Номер 33(171), С. 230141 - 230141

Опубликована: Янв. 31, 2024

Recent scientific findings in the field of sleep disordered breathing have characterised a variety phenotypes obstructive apnoea. These prompted investigations aiming to achieve more precise differentiation and description entities central apnoea (CSA). There is increasing evidence for heterogeneity CSA terms underlying aetiology, pathophysiological concepts, treatment response outcome. Assigning patients these allows selection individualised therapies. Major characteristics include loop gain, apnoeic threshold, regulation neuromuscular mechanics. Chronic heart failure most important disease, leading nonhypercapnic based on increased controller gain. Although many questions remain, this review tries describe current knowledge pathophysiology clinical entities. The prognostic aspects may guide indication pharmacotherapy invasive options. In addition, paper provides an update understanding adaptive servo-ventilation its role CSA.

Язык: Английский

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Regular snoring is associated with uncontrolled hypertension

npj Digital Medicine, Год журнала: 2024, Номер 7(1)

Опубликована: Фев. 17, 2024

Abstract Snoring may be a risk factor for cardiovascular disease independent of other co-morbidities. However, most prior studies have relied on subjective, self-report, snoring evaluation. This study assessed prevalence objectively over multiple months using in-home monitoring technology, and its association with hypertension prevalence. In this study, 12,287 participants were monitored nightly approximately six under-the-mattress sensor technology to estimate the average percentage sleep time spent per night estimated apnea-hypopnea index (eAHI). Blood pressure cuff measurements from daytime assessments averaged define uncontrolled based mean systolic blood pressure≥140 mmHg and/or diastolic ≥90 mmHg. Associations between examined logistic regressions controlled age, body mass index, sex, eAHI. Participants middle-aged (mean ± SD; 50 12 y) male (88%). There 2467 cases (20%) hypertension. Approximately 29, 14 7% population snored an >10, 20, 30% night, respectively. A higher proportion (75th vs. 5th; 12% 0.04%) was associated ~1.9-fold increase (OR [95%CI]; 1.87 [1.63, 2.15]) in apnea. Multi-night objective repeat recordings large global consumer sample, indicate that is common positively These findings highlight potential clinical utility simple, objective, noninvasive methods detect adverse health consequences.

Язык: Английский

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Depressive, anxiety, and sleep disturbance symptoms in patients with obstructive sleep apnea: a network analysis perspective

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 28, 2025

Patients with obstructive sleep apnea (OSA) frequently experience disturbance and psychological distress, such as depression anxiety, which may have a negative impact on their health status functional abilities. To gain more comprehensive understanding of the symptoms depression, in patients OSA, current study utilized network analysis to examine interconnections among these symptoms. Depressive anxiety were evaluated using Hospital Anxiety Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI). A total 621 OSA completed questionnaires. The indices 'Expected influence' 'Bridge expected used centrality measures symptom network. Least Absolute Shrinkage Selection Operator (LASSO) technique Extended Bayesian Information Criterion (EBIC) estimate structure depressive, Network Comparison Test (NCT) was performed evaluate differences between mild moderate severe networks. revealed that A6 ("Getting sudden feelings panic") had highest influence value D6 ("Feeling being slowed down") bridge values NCT results edge weights significantly differed those (M = 0.263, p 0.008). There no significant difference global strength variation two networks (S 0.185, 0.773). Our suggest (e.g., D6) can be prioritized potential targets for intervention treatment OSA.

Язык: Английский

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Diagnostic Modalities in Sleep Disordered Breathing: Current and Emerging Technology and Its Potential to Transform Diagnostics

Respirology, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

ABSTRACT Underpinned by rigorous clinical trial data, the use of existing home sleep apnoea testing is now commonly employed for disordered breathing diagnostics in most centres globally. This has been a welcome addition field given considerable burden disease, cost, and access limitations with in‐laboratory polysomnography testing. However, approaches predominantly aim to replicate elements conventional different forms focus on estimation apnoea‐hypopnoea index. New, simplified technology screening, detection/diagnosis, or monitoring expanded exponentially recent years. Emerging innovations go beyond simple single‐night replication varying numbers signals setting. These novel have potential provide important new insights overcome many transform disease diagnosis management improve outcomes patients. Accordingly, current review summarises evidence study people suspected sleep‐related disorders, discusses emerging technologies according three key categories: (1) wearables (e.g., body‐worn sensors including wrist finger sensors), (2) nearables bed‐embedded bedside (3) airables audio video recordings), outlines their disruptive role care.

Язык: Английский

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Performance of a commercial smart watch compared to polysomnography reference for overnight continuous oximetry measurement and sleep apnea evaluation

Journal of Clinical Sleep Medicine, Год журнала: 2024, Номер 20(9), С. 1479 - 1488

Опубликована: Апрель 23, 2024

We evaluated the accuracy and precision of continuous overnight oxygen saturation (SpO

Язык: Английский

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Sleep Apnea, Autonomic Disturbances, and Blood Pressure Variability

Hypertension, Год журнала: 2024, Номер 81(9), С. 1837 - 1844

Опубликована: Июль 3, 2024

Augmented blood pressure variability has emerged as a quantity predictive of adverse cardiovascular outcomes. Among the range intrinsic and extrinsic factors shown to increase night-time, circadian, short-term, long-term variations, presence severity obstructive sleep apnea have one most prevalent potent. Obstructive alters acutely normal nocturnal equilibrium between sympathetic parasympathetic tone, magnifying oscillations, induces sustained autonomic aftereffects with capacity amplify short-term intersessional variabilities. The object this brief review is synthesize current understanding potential interrelations apnea, acute disturbances that it elicits, beat-to-beat fluctuation during sleep, dipping status, day-to-day consequences these perturbations for risk.

Язык: Английский

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Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality

Journal of the American Heart Association, Год журнала: 2024, Номер 13(3)

Опубликована: Янв. 19, 2024

Obstructive sleep apnea is a well-established risk factor for cardiovascular disease (CVD). Recent studies have also linked periodic limb movements during to CVD. We aimed determine whether and obstructive are independent or synergistic factors CVD events death.

Язык: Английский

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Multi-night home assessment of sleep structure in OSA with and without insomnia

Sleep Medicine, Год журнала: 2024, Номер 117, С. 152 - 161

Опубликована: Март 24, 2024

To explore sleep structure in participants with obstructive apnea (OSA) and comorbid insomnia (COMISA) OSA without (OSA-only) using both single-night polysomnography multi-night wrist-worn photoplethysmography/accelerometry. Multi-night 4-class sleep-staging was performed a validated algorithm based on actigraphy heart rate variability, 67 COMISA (23 women, median age: 51 years) 50 OSA-only (15 51) participants. Sleep statistics were compared linear regression models mixed-effects models. variability explored clustering approach between- within-participant analysis. Polysomnographic parameters showed no significant group differences. measurements, during 13.4 ± 5.2 nights per subject, demonstrated longer onset latency lower efficiency for the group. Detailed analysis of wake revealed mean durations awakenings COMISA, as well higher numbers lasting 5 min (WKN≥5min) after containing only or longer. Within-participant variance significantly larger latency, efficiency, duration WKN≥5min. Unsupervised uncovered three clusters; consistently high values at least one parameters, low values, displaying variability. Patients more often extended, variable periods wakefulness. These observations not discernible single night polysomnography, highlighting relevance measurements to assess characteristics indicative insomnia.

Язык: Английский

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Objective sleep monitoring at home in older adults: A scoping review

Journal of Sleep Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Summary Inadequate sleep in older adults is linked to health issues such as frailty, cognitive impairment and cardiovascular disorders. Maintaining regular patterns important for healthy aging, making effective monitoring essential. While polysomnography the gold‐standard diagnosing disorders, its use home settings limited. Alternative objective methods can offer insights into natural factors affecting them without limitations of polysomnography. This scoping review aims examine current technologies, sensors parameters used home‐based adults. It also explore various predictors outcomes associated with understand at home. We identified 54 relevant articles using PubMed, Scopus, Web Science an AI tool (Research Rabbit), 48 studies wearable technologies eight non‐wearable technologies. Further, six types were utilized. The most common technology employed was actigraphy wearables, while ballistocardiography electroencephalography less common. frequent measured total time, wakeup after onset efficiency, only evaluating architecture terms stages. Additionally, categories analysed, including Health‐related, Environmental, Interventional, Behavioural, Time Place, Social associations. These associations correlate include in‐bed behaviours, exterior housing conditions, aerobic exercise, living place, relationship status, seasonal thermal environments.

Язык: Английский

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The Future of Telemedicine for Obstructive Sleep Apnea Treatment: A Narrative Review

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(9), С. 2700 - 2700

Опубликована: Май 4, 2024

Obstructive sleep apnea is a common type of sleep-disordered breathing associated with multiple comorbidities. Nearly billion people are estimated to have obstructive apnea, which carries substantial economic burden, but under-diagnosis still problem. Continuous positive airway pressure (CPAP) the first-line treatment for OSAS. Telemedicine-based interventions (TM) been evaluated improve access diagnosis, increase CPAP adherence, and contribute easing follow-up process, allowing healthcare facilities provide patient-centered care. This narrative review summarizes evidence available regarding potential future telemedicine in management pathway OSA. The home studies OSA diagnosis importance remote monitoring tracking adherence failure developing patient engagement tools will be presented. Further needed explore impact shifting from teleconsultations collaborative care models where patients placed at center their

Язык: Английский

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