The American Journal of Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
European Respiratory Review, Journal Year: 2024, Volume and Issue: 33(171), P. 230141 - 230141
Published: Jan. 31, 2024
Recent scientific findings in the field of sleep disordered breathing have characterised a variety phenotypes obstructive apnoea. These prompted investigations aiming to achieve more precise differentiation and description entities central apnoea (CSA). There is increasing evidence for heterogeneity CSA terms underlying aetiology, pathophysiological concepts, treatment response outcome. Assigning patients these allows selection individualised therapies. Major characteristics include loop gain, apnoeic threshold, regulation neuromuscular mechanics. Chronic heart failure most important disease, leading nonhypercapnic based on increased controller gain. Although many questions remain, this review tries describe current knowledge pathophysiology clinical entities. The prognostic aspects may guide indication pharmacotherapy invasive options. In addition, paper provides an update understanding adaptive servo-ventilation its role CSA.
Language: Английский
Citations
14
npj Digital Medicine, Journal Year: 2024, Volume and Issue: 7(1)
Published: Feb. 17, 2024
Abstract Snoring may be a risk factor for cardiovascular disease independent of other co-morbidities. However, most prior studies have relied on subjective, self-report, snoring evaluation. This study assessed prevalence objectively over multiple months using in-home monitoring technology, and its association with hypertension prevalence. In this study, 12,287 participants were monitored nightly approximately six under-the-mattress sensor technology to estimate the average percentage sleep time spent per night estimated apnea-hypopnea index (eAHI). Blood pressure cuff measurements from daytime assessments averaged define uncontrolled based mean systolic blood pressure≥140 mmHg and/or diastolic ≥90 mmHg. Associations between examined logistic regressions controlled age, body mass index, sex, eAHI. Participants middle-aged (mean ± SD; 50 12 y) male (88%). There 2467 cases (20%) hypertension. Approximately 29, 14 7% population snored an >10, 20, 30% night, respectively. A higher proportion (75th vs. 5th; 12% 0.04%) was associated ~1.9-fold increase (OR [95%CI]; 1.87 [1.63, 2.15]) in apnea. Multi-night objective repeat recordings large global consumer sample, indicate that is common positively These findings highlight potential clinical utility simple, objective, noninvasive methods detect adverse health consequences.
Language: Английский
Citations
9
Journal of Clinical Sleep Medicine, Journal Year: 2024, Volume and Issue: 20(9), P. 1479 - 1488
Published: April 23, 2024
We evaluated the accuracy and precision of continuous overnight oxygen saturation (SpO
Language: Английский
Citations
8
BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 28, 2025
Patients with obstructive sleep apnea (OSA) frequently experience disturbance and psychological distress, such as depression anxiety, which may have a negative impact on their health status functional abilities. To gain more comprehensive understanding of the symptoms depression, in patients OSA, current study utilized network analysis to examine interconnections among these symptoms. Depressive anxiety were evaluated using Hospital Anxiety Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI). A total 621 OSA completed questionnaires. The indices 'Expected influence' 'Bridge expected used centrality measures symptom network. Least Absolute Shrinkage Selection Operator (LASSO) technique Extended Bayesian Information Criterion (EBIC) estimate structure depressive, Network Comparison Test (NCT) was performed evaluate differences between mild moderate severe networks. revealed that A6 ("Getting sudden feelings panic") had highest influence value D6 ("Feeling being slowed down") bridge values NCT results edge weights significantly differed those (M = 0.263, p 0.008). There no significant difference global strength variation two networks (S 0.185, 0.773). Our suggest (e.g., D6) can be prioritized potential targets for intervention treatment OSA.
Language: Английский
Citations
1
Hypertension, Journal Year: 2024, Volume and Issue: 81(9), P. 1837 - 1844
Published: July 3, 2024
Augmented blood pressure variability has emerged as a quantity predictive of adverse cardiovascular outcomes. Among the range intrinsic and extrinsic factors shown to increase night-time, circadian, short-term, long-term variations, presence severity obstructive sleep apnea have one most prevalent potent. Obstructive alters acutely normal nocturnal equilibrium between sympathetic parasympathetic tone, magnifying oscillations, induces sustained autonomic aftereffects with capacity amplify short-term intersessional variabilities. The object this brief review is synthesize current understanding potential interrelations apnea, acute disturbances that it elicits, beat-to-beat fluctuation during sleep, dipping status, day-to-day consequences these perturbations for risk.
Language: Английский
Citations
7
Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(3)
Published: Jan. 19, 2024
Obstructive sleep apnea is a well-established risk factor for cardiovascular disease (CVD). Recent studies have also linked periodic limb movements during to CVD. We aimed determine whether and obstructive are independent or synergistic factors CVD events death.
Language: Английский
Citations
5
Sleep Medicine, Journal Year: 2024, Volume and Issue: 117, P. 152 - 161
Published: March 24, 2024
To explore sleep structure in participants with obstructive apnea (OSA) and comorbid insomnia (COMISA) OSA without (OSA-only) using both single-night polysomnography multi-night wrist-worn photoplethysmography/accelerometry. Multi-night 4-class sleep-staging was performed a validated algorithm based on actigraphy heart rate variability, 67 COMISA (23 women, median age: 51 years) 50 OSA-only (15 51) participants. Sleep statistics were compared linear regression models mixed-effects models. variability explored clustering approach between- within-participant analysis. Polysomnographic parameters showed no significant group differences. measurements, during 13.4 ± 5.2 nights per subject, demonstrated longer onset latency lower efficiency for the group. Detailed analysis of wake revealed mean durations awakenings COMISA, as well higher numbers lasting 5 min (WKN≥5min) after containing only or longer. Within-participant variance significantly larger latency, efficiency, duration WKN≥5min. Unsupervised uncovered three clusters; consistently high values at least one parameters, low values, displaying variability. Patients more often extended, variable periods wakefulness. These observations not discernible single night polysomnography, highlighting relevance measurements to assess characteristics indicative insomnia.
Language: Английский
Citations
4
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(9), P. 2700 - 2700
Published: May 4, 2024
Obstructive sleep apnea is a common type of sleep-disordered breathing associated with multiple comorbidities. Nearly billion people are estimated to have obstructive apnea, which carries substantial economic burden, but under-diagnosis still problem. Continuous positive airway pressure (CPAP) the first-line treatment for OSAS. Telemedicine-based interventions (TM) been evaluated improve access diagnosis, increase CPAP adherence, and contribute easing follow-up process, allowing healthcare facilities provide patient-centered care. This narrative review summarizes evidence available regarding potential future telemedicine in management pathway OSA. The home studies OSA diagnosis importance remote monitoring tracking adherence failure developing patient engagement tools will be presented. Further needed explore impact shifting from teleconsultations collaborative care models where patients placed at center their
Language: Английский
Citations
4
Sleep And Breathing, Journal Year: 2025, Volume and Issue: 29(1)
Published: Jan. 20, 2025
Abstract Purpose This study aimed to validate the new DormoTech Vlab device’s performance, usability, and validity as a sleep test physiological data recorder. The novel device has been designed for patient comfort, ease of use, home-based assessment disordered breathing other sleep-related measurements. Methods Forty-seven adults (mean age = 52 years, 42% female, body mass index 29.4 kg/m 2 ) underwent simultaneous testing with routine full polysomnography (PSG) using Nox A1 system (K192469, Medical). studies were manually independently scored according recommended guidelines. primary outcome measure was apnea-hypopnea (AHI) its corresponding conventional severity level (i.e., normal, mild, moderate, severe). Secondary endpoints included standard PSG parameters. Results AHI 21.7 ± 24.2 events/h deviation) versus 21.5 23.9 gold ( p 0.7). When grouped by severity, inter-test agreement high (Cohen’s kappa 0.97). between two systems largely similar in secondary endpoints, correlation systems, statistically significant < 0.05) differences only REM latency provides clinically near-identical interpretation almost all cases. Conclusion Based on these results, can be considered substantially equivalent reference terms efficacy, validity. Clinical Trial Registration name: Evaluation Usability Performance Assessment VLAB Device Home Sleep Test Identification number: NCT06224972. Date Registration: 2023-12-06.
Language: Английский
Citations
0
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 877 - 890
Published: Feb. 1, 2025
Purpose: The provision of comfortable and safe environment for painless gastroscopy in obese patients is an urgent clinical problem. This study aimed to determine the efficacy safety novel Li anesthetic protocol obesity (LAPO) which included remifentanil-propofol regimen, manual right hypochondrial compression (MRHC), easy-to-create mask, jaw thrust at preoperative patients. Patients Methods: prospective, single-center, single-arm trial recruited 106 participants underwent LAPO gastroscopy. primary outcome was incidence hypoxemia (peripheral oxygen saturation [SpO 2 ]: 75% ≤ SpO < 90%, > 10 s 60 s). Second outcomes severe hypoxemia, lowest (L-SpO ), duration other events. Results: 98 under LAPO, median body mass index (BMI) 39.2 kg/m 27.5%, while conventional (CAPO) reference 40.4% with BMI 31.4 . With increase class obesity, a significant rise observed, from I by 11.8%, 15.1% II, 41.7% III. Paired t test showed that L-SpO significantly higher than overnight polysomnography (Nadir ) (92% vs 76%, P< 0.001). Moreover, obstructive sleep apnea (OSA) associated 4.019-fold risk (Odds ratios [OR], 4.019; 95% confidence interval [CI], 1.184 14.610; P=0.028); diabetes 4.790-fold (OR, 4.790; CI, 1.288 23.600; P=0.030). Conclusion: Compared CAPO, reduced so, effective finding might provide some new schedules management absence advanced airway support instruments. Clinical Trial Registration: ChiCTR2300077889. Plain Language Summary: advancement comfortable-oriented medication, mostly performed sedation anesthesia. However, there are changes anatomy structure such as short neck, round chin, large tongue, makes them prone obstruction after or anesthesia, blocking passage out, will cause over time further damage body. Therefore, it necessary explore anesthesia obesity. Our team's work demonstrates (strategic remifentanil combined propofol respiratory through MRHC thrust, increased reserve via mask) lacking devices efficient. Furthermore, our findings contribute understanding values can tolerate during procedures, establishing Nadir cut-off point. We also identified OSA independent predictive factors hypoxemia. If these supported research, could aid anesthesiologists developing specific protocols managing Ultimately, this expand access medical treatment broader spectrum Keywords: compression, patient, apnea, gastroscopy, propofol,
Language: Английский
Citations
0