Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy

Chemical Society Reviews, Год журнала: 2022, Номер 51(21), С. 8957 - 9008

Опубликована: Янв. 1, 2022

We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.

Язык: Английский

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A hemicyanine-based fluorescent probe for ratiometric detection of ClO- and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish

Sensors and Actuators B Chemical, Год журнала: 2023, Номер 383, С. 133510 - 133510

Опубликована: Фев. 13, 2023

A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratiometric response toward hypochlorite (ClO-) with the LOD (0.082 μM), and "turn-on" to viscosity changes. Due low cytotoxicity good biocompatibility, used monitor hypochlorous acid in mitochondria of living cells zebrafish.

Язык: Английский

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Fluorescent Probes as a Tool in Diagnostic and Drug Delivery Systems

Pharmaceuticals, Год журнала: 2023, Номер 16(3), С. 381 - 381

Опубликована: Март 1, 2023

Over the last few years, development of fluorescent probes has received considerable attention. Fluorescence signaling allows noninvasive and harmless real-time imaging with great spectral resolution in living objects, which is extremely useful for modern biomedical applications. This review presents basic photophysical principles strategies rational design as visualization agents medical diagnosis drug delivery systems. Common phenomena, such Intramolecular Charge Transfer (ICT), Twisted (TICT), Photoinduced Electron (PET), Excited-State Proton (ESIPT), Fluorescent Resonance Energy (FRET), Aggregation-Induced Emission (AIE), are described platforms fluorescence sensing vivo vitro. The presented examples focused on pH, biologically important cations anions, reactive oxygen species (ROS), viscosity, biomolecules, enzymes that find application diagnostic purposes. general regarding molecular logic devices fluorescence-drug conjugates theranostic systems discussed. work could be help researchers working field compounds, gates, delivery.

Язык: Английский

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Recent progress and outlooks in rhodamine-based fluorescent probes for detection and imaging of reactive oxygen, nitrogen, and sulfur species

Talanta, Год журнала: 2024, Номер 274, С. 126004 - 126004

Опубликована: Апрель 1, 2024

Язык: Английский

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An ultra-sensitive ESIPT fluorescent probe for distinguishing cancerous cells and diagnosing APAP-induced liver injury via HClO fluctuation

Sensors and Actuators B Chemical, Год журнала: 2023, Номер 386, С. 133749 - 133749

Опубликована: Март 30, 2023

Язык: Английский

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Tuning the Cellular Uptake and Retention of Rhodamine Dyes by Molecular Engineering for High‐Contrast Imaging of Cancer Cells

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(17)

Опубликована: Март 1, 2023

Probes allowing high-contrast discrimination of cancer cells and effective retention are powerful tools for the early diagnosis treatment cancer. However, conventional small-molecule probes often show limited performance in both aspects. Herein, we report an ingenious molecular engineering strategy tuning cellular uptake rhodamine dyes. Introduction polar aminoethyl leads to increased brightness reduced dyes, this change can be reversed by amino acetylation. Moreover, these modifications allow take up more dyes than normal (16-fold) through active transport. Specifically, further improve signal contrast (56-fold) between constructing activatable confirm that released fluorophore remain with extended time, enabling long-term specific tumor imaging.

Язык: Английский

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A triphenylamine-based fluorescence probe for detection of hypochlorite in mitochondria

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2023, Номер 299, С. 122830 - 122830

Опубликована: Май 10, 2023

Язык: Английский

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A novel fluorescent probe based on carbazole-thiophene for the recognition of hypochlorite and its applications

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 310, С. 123912 - 123912

Опубликована: Янв. 22, 2024

Язык: Английский

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Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes

Chemical Reviews, Год журнала: 2024, Номер 124(16), С. 9225 - 9375

Опубликована: Авг. 13, 2024

Reactive oxygen and nitrogen species are small reactive molecules derived from elements in the air─oxygen nitrogen. They produced biological systems to mediate fundamental aspects of cellular signaling but must be very tightly balanced prevent indiscriminate damage molecules. Small molecule probes can transmute specific nature each into an observable luminescent signal (or even acoustic wave) offer sensitive selective imaging living cells whole animals. This review focuses specifically on for superoxide, hydrogen peroxide, hypochlorite, nitric oxide, peroxynitrite that provide a or photoacoustic signal. Important background information general photophysical phenomena, common probe designs, mechanisms, modalities will provided, then, analyte thoroughly evaluated. A discussion successes field presented, followed by recommendations improvement future outlook emerging trends. Our objectives informative, useful, thorough guide as well important context compare ecosystem chemistries molecular scaffolds has manifested within field.

Язык: Английский

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A highly sensitive and fast-response fluorescence nanoprobe for in vivo imaging of hypochlorous acid

Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137282 - 137282

Опубликована: Янв. 18, 2025

Язык: Английский

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