Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

Polymers, Год журнала: 2023, Номер 15(23), С. 4563 - 4563

Опубликована: Ноя. 28, 2023

Polymeric drug delivery technology, which allows for medicinal ingredients to enter a cell more easily, has advanced considerably in recent decades. Innovative medication strategies use biodegradable and bio-reducible polymers, progress the field been accelerated by future possible research applications. Natural polymers utilized polymeric systems include arginine, chitosan, dextrin, polysaccharides, poly(glycolic acid), poly(lactic hyaluronic acid. Additionally, poly(2-hydroxyethyl methacrylate), poly(N-isopropyl acrylamide), poly(ethylenimine), dendritic bioabsorbable as well biomimetic bio-related drug-free macromolecular therapies have employed delivery. Different synthetic natural biomaterials are clinical phase mitigate different diseases. Drug methods using becoming increasingly common pharmaceutical industry, with biocompatible copolymers dendrimers having helped cure cancer systems. This review discusses all above components how, combining biological approaches, micro- nano-drug can result revolutionary gene devices.

Язык: Английский

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Unraveling the structure–property relationships in fluorescent phenylhydrazones: the role of substituents and molecular interactions

RSC Advances, Год журнала: 2025, Номер 15(3), С. 1514 - 1526

Опубликована: Янв. 1, 2025

This study investigates the structure-property relationships of a series phenylhydrazones bearing various electron-donating and electron-withdrawing substituents, such as methoxy, dimethylamino, morpholinyl, hydroxyl, chloro, bromo, nitro groups. The compounds were synthesized, their structures characterized using single-crystal X-ray diffraction, powder FTIR spectroscopy, NMR DSC. Three-dimensional excitation-emission matrix (3D-EEM) fluorescence spectroscopy UV-Vis employed to elucidate complex interplay between molecular skeleton, resulting photophysical properties. Quantum mechanical calculations provided further insights into electronic structure excited-state dynamics investigated compounds. exhibited emission wavelengths ranging from 438 482 nm, with backbone playing crucial role in determining wavelength. incorporation methoxy dimethylamino groups, led enhanced intensity, while presence resulted complete quenching. comprehensive establishes rational design principles for development highly emissive tuned properties highlights significance skeleton dictating behavior this class

Язык: Английский

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Water-Soluble Small Organic Fluorophores for Oncological Theragnostic Applications: Progress and Development

Topics in Current Chemistry, Год журнала: 2024, Номер 382(2)

Опубликована: Апрель 26, 2024

Язык: Английский

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Recent advances in small-molecules fluorescent probes bearing Salicylaldehyde unit and their sensing & bio-imaging applications

Journal of Molecular Structure, Год журнала: 2024, Номер 1317, С. 139086 - 139086

Опубликована: Июнь 21, 2024

Язык: Английский

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Design and Screening of Fluorescent Probes Based upon Hemicyanine Dyes for Monitoring Mitochondrial Viscosity in Living Cells

The Journal of Physical Chemistry B, Год журнала: 2024, Номер 128(16), С. 3910 - 3918

Опубликована: Апрель 12, 2024

Viscosity, at the subcellular level, plays a crucial role as physicochemical factor affecting microenvironment homeostasis. Abnormal changes in mitochondrial viscosity often lead to various diseases organism. Based on twisted intramolecular charge transfer mechanism, four hemicyanine dye fluorescent probes (HT-SA, HT-SA-S, HT-Bzh, and HT-NA) were designed synthesized for response. The single bond between nitrogen-containing heterocycle carbon–carbon double structure of probe served response site. Finally, HT-Bzh was screened optimal according its responsiveness, targeting, interference resistance. fluorescence intensity increased 22-fold when from 13.75 811.2 cP. In summary, all we have developed can be used different applications depending external environment, providing valuable reference design potential tools address monitoring biological systems.

Язык: Английский

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Recent Progress in ESIPT-Based Fluorescent Chemosensors for Detection of Zn2+, Mg2+ and Cu2+

Dyes and Pigments, Год журнала: 2024, Номер unknown, С. 112509 - 112509

Опубликована: Окт. 1, 2024

Язык: Английский

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Comparison of methods for rapid assessment of selectivity and efficiency of the analytical signal of fluorescent phases of different natures

Журнал аналитической химии, Год журнала: 2025, Номер 79(7), С. 782 - 799

Опубликована: Янв. 6, 2025

Язык: Английский

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Unraveling the mechanisms underlying the fluorescent probe detection of microcystin-LR and its binding with CT-DNA

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139873 - 139873

Опубликована: Янв. 1, 2025

Язык: Английский

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Carbamate‐Functionalized NLOphores via a Formal [2+2] Cycloaddition‐Retroelectrocyclization Strategy

Chemistry - A European Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

This study introduces a new donor group capable of activating click-type [2+2] cycloaddition-retroelectrocyclizations, generally known for their limited scope. Target chromophores were synthesized using isocyanate-free urethane synthesis. The developed synthetic method allows the tuning optical properties by modifying groups, acceptor units, and side chains. charge transfer (CT) bands exhibit λmax values ranging from 363 to 692 nm. CT observed have been supported solvatochromism protonation experiments. compounds positive solvatochromism. Due potential as NLOphore candidates, stability investigated both experimentally through TGA theoretically calculating parameters such frontier orbital energy differences, electronegativity, global hardness/softness. TD-DFT calculations used elucidate nature electronic transitions, revealing that correspond arising HOMO-to-LUMO excitations. NLO DFT methods EFISHG technique. Both results are shown be in agreement with HOMO-LUMO differences. experimental μβ selected molecules range 470×10-48 5400×10-48 esu.

Язык: Английский

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Design strategies of fluorescent covalent organic frameworks and visual on-site monitoring of food freshness: A state-of-the-art review

TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер 187, С. 118226 - 118226

Опубликована: Март 3, 2025

Язык: Английский

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