Talanta Open,
Год журнала:
2023,
Номер
7, С. 100218 - 100218
Опубликована: Апрель 25, 2023
Severe
acute
respiratory
syndrome-coronavirus-2
(SARS-CoV-2)
was
declared
a
global
pandemic
in
2020.
Having
rapidly
spread
around
the
globe,
with
emergence
of
new
variants,
there
is
crucial
need
to
develop
diagnostic
kits
for
its
rapid
detection.
Since
it
validated
accuracy
and
reliability,
reverse
transcription
polymerase
chain
reaction
(RT-PCR)
test
has
been
gold
standard
disease
However,
despite
requirement
specialized
facilities,
reagents,
duration
PCR
run
limits
usage
There
thus
continuous
increase
design
development
rapid,
point-of-care
(PoC),
cost-effective
kits.
In
this
review,
we
discuss
potential
carbon-based
biosensors
target-specific
detection
coronavirus
19
(COVID-19)
present
an
overview
investigation
within
timeframe
last
four
years
(2019-2022),
which
have
developed
novel
platforms
using
carbon
nanomaterial-based
approaches
viral
The
discussed
offer
accurate,
strategies
COVID-19
healthcare
personnel
research
workers.
Abstract
The
focus
on
precise
medicine
enhances
the
need
for
timely
diagnosis
and
frequent
monitoring
of
chronic
diseases.
Moreover,
recent
pandemic
severe
acute
respiratory
syndrome
coronavirus
2
poses
a
great
demand
rapid
detection
surveillance
viral
infections.
protein
biomarkers
antigens
in
saliva
allows
identification
diseases
or
disease
changes
scenarios
where
when
test
response
at
point
care
is
mandated.
While
traditional
methods
testing
fail
to
provide
desired
fast
results,
electrochemical
biosensors
based
nanomaterials
hold
perfect
characteristics
point‐of‐care
settings.
advances
sensors
salivary
are
critically
reviewed
this
work,
with
emphasis
role
boost
biosensor
analytical
performance
increase
reliability
human
samples.
Furthermore,
work
identifies
critical
factors
further
modernization
nanomaterial‐based
sensors,
envisaging
development
implementation
next‐generation
sample‐in‐answer‐out
systems.
ACS Omega,
Год журнала:
2022,
Номер
7(15), С. 12467 - 12473
Опубликована: Апрель 5, 2022
Rapid
diagnosis
is
a
critical
aspect
associated
with
controlling
the
spread
of
COVID-19.
Electrochemical
sensor
platforms
are
ideally
suited
for
rapid
and
highly
sensitive
detection
biomolecules.
This
review
focuses
on
state-of-the-art
COVID-19
biomarker
by
utilizing
electrochemical
biosensing
platforms.
Point-of-care
(POC)
sensing
one
most
promising
emerging
fields
in
detecting
quantifying
health
biomarkers.
biosensors
play
major
role
development
point-of-care
devices
because
their
high
sensitivity,
specificity,
ability
analysis.
Integration
electrochemistry
technologies
context
screening
has
facilitated
convenient
operation,
miniaturization,
portability.
Identification
potential
biomarkers
disease
crucial
patient
monitoring
concerning
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
In
this
review,
we
will
discuss
choice
addition
to
various
types
sensors
that
have
been
developed
meet
needs
severity
Abstract
Peptides
have
become
an
indispensable
tool
in
engineering
of
multifunctional
nanostructure
platforms
for
biomedical
applications
such
as
targeted
drug
and
gene
delivery,
imaging
biosensing.
They
can
be
covalently
incorporated
into
a
variety
nanoparticles
(NPs)
including
polymers,
metallic
nanoparticles,
others.
Using
different
bioconjugation
techniques,
peptide‐modified
NPs
formulated
to
produce
therapeutical
diagnostic
offering
high
specificity,
lower
toxicity,
biocompatibility,
stimuli
responsive
behavior.
Targeting
peptides
direct
the
specific
tissues
delivery
due
their
specificity
towards
certain
receptors.
Furthermore,
stimuli‐responsive
features,
they
offer
controlled
release
therapeutics
desired
sites
disease.
In
addition,
peptide‐based
biosensors
agents
provide
non‐invasive
detection
monitoring
diseases
cancer,
infectious
diseases,
neurological
disorders.
this
review,
we
covered
design
formulation
recent
NP
platforms,
well
utilization
vitro
vivo
targeting,
sensing,
applications.
end,
provided
future
outlook
new
peptide
conjugated
nanomaterials
Chemosensors,
Год журнала:
2022,
Номер
10(7), С. 287 - 287
Опубликована: Июль 20, 2022
Rapid
and
early
diagnosis
of
lethal
coronavirus
disease-19
(COVID-19)
caused
by
the
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
is
an
important
issue
considering
global
human
health,
economy,
education,
other
activities.
The
advancement
understanding
chemistry/biochemistry
structure
SARS-CoV-2
virus
has
led
to
development
low-cost,
efficient,
reliable
methods
for
COVID-19
over
“gold
standard”
real-time
reverse
transcription-polymerase
chain
reaction
(RT-PCR)
due
its
several
limitations.
This
electrochemical
sensors/biosensors
rapid,
fast,
low-cost
detection
from
patient’s
biological
fluids
detecting
components
virus,
including
structural
proteins
(antigens),
nucleic
acid,
antibodies
created
after
infection.
review
comprehensively
summarizes
state-of-the-art
research
progress
biosensors
diagnosis.
They
include
spike
protein,
nucleocapsid
whole
antibodies.
also
outlines
different
methods,
design
strategies
highlighting
current
challenges
future
perspectives.
