Selective Visualization of Tumor Cell Membranes and Tumors with a Viscosity-Sensitive Plasma Membrane Probe

Analytical Chemistry, Год журнала: 2023, Номер 95(18), С. 7254 - 7261

Опубликована: Апрель 26, 2023

Cancer is a worldwide health problem. Revealing the changes in microenvironment after cell carcinogenesis helpful to understand cancer and develop sensitive methods for diagnosis. We developed herein viscosity-responsive plasma membrane probe (TPA-S) that was successfully used viscosity difference between normal tumor membranes first time. The shows AIE properties with good water solubility, significant near-infrared (NIR) fluorescence responses high sensitivity, excellent location performance. With these features, our experiments showed TPA-S could selectively visualize membranes, revealing of cells more viscous than cells. In addition, applied specifically light up tumors. Altogether, this work explored canceration, provided new method selective visualization cells, opened approach

Язык: Английский

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Recent Advances in Fluorescent Probes for Cancer Biomarker Detection

Molecules, Год журнала: 2024, Номер 29(5), С. 1168 - 1168

Опубликована: Март 6, 2024

Many important biological species have been identified as cancer biomarkers and are gradually becoming reliable targets for early diagnosis late therapeutic evaluation of cancer. However, accurate quantitative detection remains challenging due to the complexity systems diversity development. Fluorescent probes extensively utilized identifying substances their notable benefits being non-invasive, quickly responsive, highly sensitive selective, allowing real-time visualization, easily modifiable. This review critiques fluorescent used detecting imaging over last five years. Focuses made on design strategies small-molecule nano-sized probes, construction methods fluorescence sensing platforms, further applications in multiple biomarkers, including enzymes, reactive oxygen species, sulfur microenvironments. aims guide development excellent diagnostic promote broad application analysis diagnosis.

Язык: Английский

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Dissecting lysosomal viscosity fluctuations in live cells and liver tissues with an ingenious NIR fluorescent probe

Talanta, Год журнала: 2024, Номер 272, С. 125825 - 125825

Опубликована: Фев. 23, 2024

Язык: Английский

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Water-soluble fluorescent probes for differentiating cancer cells and normal cells by tracking lysosomal viscosity

Chemical Communications, Год журнала: 2023, Номер 59(24), С. 3570 - 3573

Опубликована: Янв. 1, 2023

Lysosomal viscosity is a significant parameter of lysosomes and closely related to various diseases. Herein, two fluorescent probes, Lyso-vis-A Lyso-vis-B, were developed, which demonstrate diverse advantages, including great water solubility, lysosome targeting ability sensitivity. In particular, exclusively showed fluorescence response toward but was not influenced by pH changes, rendering it selective lysosomal probe. Furthermore, successfully applied monitor variations in living cells differentiate cancer normal cells.

Язык: Английский

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Exquisite visualization of mitophagy and monitoring the increase of lysosomal micro-viscosity in mitophagy with an unusual pH-independent lysosomal rotor

Analytica Chimica Acta, Год журнала: 2024, Номер 1302, С. 342506 - 342506

Опубликована: Март 19, 2024

Язык: Английский

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Dual-response and lysosome-targeted fluorescent probe for viscosity and sulfur dioxide derivatives

Analytica Chimica Acta, Год журнала: 2022, Номер 1239, С. 340721 - 340721

Опубликована: Дек. 14, 2022

Язык: Английский

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FRET-based fluorescent probe with favorable water solubility for simultaneous detection of SO2 derivatives and viscosity

Talanta, Год журнала: 2023, Номер 256, С. 124302 - 124302

Опубликована: Янв. 24, 2023

Язык: Английский

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Organic Fluorescent Probes for Monitoring Micro-Environments in Living Cells and Tissues

Molecules, Год журнала: 2023, Номер 28(8), С. 3455 - 3455

Опубликована: Апрель 14, 2023

As a vital parameter in living cells and tissues, the micro-environment is crucial for organisms. Significantly, organelles require proper to achieve normal physiological processes, can reflect state of cells. Moreover, some abnormal micro-environments are closely related organelle dysfunction disease development. So, visualizing monitoring variation helpful physiologists pathologists study mechanisms relative diseases. Recently, large variety fluorescent probes was developed tissues. However, systematic comprehensive reviews on tissues have rarely been published, which may hinder research progress field organic probes. In this review, we will summarize microenvironment, such as viscosity, pH values, polarity, temperature. Further, diverse (mitochondria, lysosome, endoplasmic reticulum, cell membrane) about microenvironments be displayed. process, “off-on” ratiometric category (the fluorescence emission) discussed. molecular designing, chemical synthesis, mechanism, bio-applications these also merits defects current microenvironment-sensitive outlined discussed, development tendency challenges kind probe presented. brief, review mainly summarizes typical examples highlights recent research. We anticipate that deepen understanding microenvironment facilitate studies physiology pathology.

Язык: Английский

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A benzothiazole-salt-based fluorescent probe for precise monitoring the changes of pH and viscosity

Talanta, Год журнала: 2023, Номер 266, С. 125049 - 125049

Опубликована: Авг. 7, 2023

Язык: Английский

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NBD-based colorimetric and ratiometric fluorescent probe in NIR for bisulfite

Talanta, Год журнала: 2024, Номер 271, С. 125684 - 125684

Опубликована: Янв. 17, 2024

Язык: Английский

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