Gallic
acid
(GA),
widely
used
in
food
and
medicine
production
industries.
Herein,
a
kind
of
newly
synthesized
cobalt-nitrogen
co-doped
carbon
dots
(Co,N-CDs)
with
dual
functional
properties
oxidase-like
activity
photoluminescence
property
could
oxidize
the
3,3',5,5'-tetramethylbenzidine
(TMB)
to
oxTMB
new
absorption
peak
at
653
nm.
In
addition,
it
was
found
that
performed
fluorescence-quenching
effect
on
Co,N-CDs
440
nm
attributed
FRET
(Fluorescence
resonance
energy
transfer).
Reductive
GA
reduce
TMB,
weaken
blue
color,
restore
fluorescence
Co,N-CDs.
Thus,
colorimetric
fluorometric
method
for
dual-mode
detection
established.
The
synthesis
dual-signal
probe
completed
single
environmental
precursor
just
one
step.
Simultaneously,
reduced
limits,
broadened
linear
range
improved
anti-interference
ability.
This
exhibited
satisfactory
application
prospect
actual
tea
beverages.
Advanced Materials,
Год журнала:
2024,
Номер
36(31)
Опубликована: Апрель 14, 2024
Although
nanozymes
have
drawn
great
attention
over
the
past
decade,
activities
of
peroxidase-like,
oxidase-like,
and
catalase-like
are
often
pH
dependent
with
elusive
mechanism,
which
largely
restricts
their
application.
Therefore,
a
systematical
discussion
on
pH-related
catalytic
mechanisms
together
methods
to
overcome
this
limitation
is
in
need.
In
review,
various
exhibiting
pH-dependent
collected
root
causes
for
dependence
comprehensively
analyzed.
Subsequently,
regulatory
concepts
including
environment
reconstruction
direct
activity
improvement
break
restriction
summarized.
Moreover,
applications
pH-independent
sensing,
disease
therapy,
pollutant
degradation
overviewed.
Finally,
current
challenges
future
opportunities
development
suggested.
It
anticipated
that
review
will
promote
further
design
broaden
application
range
higher
efficiency.
Environmental Science Nano,
Год журнала:
2024,
Номер
11(3), С. 766 - 796
Опубликована: Янв. 1, 2024
Here
we
made
a
critical
review
on
nanozyme-involved
detection
and
degradation
of
environmental
pollutants,
the
research
progress
achieved
in
last
five
years
was
emphatically
concluded.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(28), С. 11353 - 11365
Опубликована: Июль 6, 2024
Biothiols
play
essential
roles
in
maintaining
normal
physiological
functions,
resisting
oxidative
stress,
and
protecting
cell
health.
Establishing
an
effective
reliable
sensor
array
for
the
accurate
quantification
discrimination
of
diverse
biothiols
is
extremely
meaningful.
In
this
work,
Ag/Mn3O4,
Ag3PO4,
Ag3Cit
with
excellent
oxidase-mimetic
activity
surface-enhanced
Raman
scattering
(SERS)-enhanced
features
have
been
prepared
loaded
onto
Whatman
filter
paper
(WFP)
to
build
SERS
chips
as
three
sensing
channels,
which
can
induce
3,3′,5,5′-tetramethylbenzidine
(TMB)
oxidation
SERS-active
reporters
(TMBox)
concurrently
generate
prominent
signals.
Nevertheless,
addition
suppress
conversion
from
TMB
TMBox,
cause
reduction
signal
TMBox.
Interestingly,
each
channel
different
TMBox
signals'
variations
due
differences
inhibition
abilities
exclusive
properties
chip,
be
plotted
specific
fingerprint
patterns
biothiol
further
translated
into
intuitive
two-dimensional
(2D)
clustering
profiles
through
linear
discriminant
analysis
(LDA)
hierarchical
cluster
(HCA)
techniques
precise
identification
these
six
minimum
concentration
1
μM.
More
importantly,
exploited
intracellular
glutathione
(GSH),
differentiate
between
cancer
cells
based
on
GSH
contents
even
identify
types
tumor
cells,
demonstrating
its
powerful
application
prospects
disease
diagnosis.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2024,
Номер
23(4)
Опубликована: Июнь 25, 2024
Abstract
Low‐cost,
reliable,
and
efficient
biosensors
are
crucial
in
detecting
residual
heavy
metal
ions
(HMIs)
food
products.
At
present,
based
on
distance‐induced
localized
surface
plasmon
resonance
of
noble
nanoparticles,
enzyme‐mimetic
reaction
nanozymes,
chelation
chelators,
the
constructed
optical
sensors
have
attracted
wide
attention
HMIs
detection.
Besides,
enrichment
signal
amplification
strategy
nanomaterials
construction
electrochemical
aptamer
sensing
platforms,
developed
overcome
plague
low
sensitivity,
poor
selectivity,
inability
multiplexed
detection
strategy.
Moreover,
along
with
an
in‐depth
discussion
these
different
types
biosensors,
a
detailed
overview
design
application
innovative
devices
principles
was
provided,
including
microfluidic
systems,
hydrogel‐based
test
strip
technologies.
Finally,
challenges
that
hinder
commercial
also
been
mentioned.
Overall,
this
review
aims
to
establish
theoretical
foundation
for
developing
accurate
reliable
technologies
HMIs,
thereby
promoting
widespread
food.
