Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

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Zinc Oxide‐Enhanced Copper Sulfide Nanozymes Promote the Healing of Infected Wounds by Activating Immune and Inflammatory Responses

Small, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 9, 2024

Bacterial infection and an excessive inflammatory response are two major factors that affect the healing of infected wounds. The zinc oxide/copper sulfide (ZnO-CuS) microspheres (MSs) developed in this work can kill bacteria resist inflammation. ZnO-CuS exhibits different enzyme-like activities depending on pH. In acidic environments, peroxidase-like (POD-like) activity convert hydrogen peroxide (H

Язык: Английский

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Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Сен. 10, 2024

Язык: Английский

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A Novel Ce─Mn Heterojunction‐Based Multi‐Enzymatic Nanozyme with Cancer‐Specific Enzymatic Activity and Photothermal Capacity for Efficient Tumor Combination Therapy

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Abstract Catalytic medicine, using enzymes or nanozymes, is an emerging method for cancer treatment. However, its applicability limited by the low catalytic activity in tumor microenvironment (TME). In this work, a versatile and synthesis‐friendly nanozyme, CeO 2 Mn 1.08 O x nanoclusters, prepared. This novel Ce─Mn heterojunction formed oxidation of nanoparticles through H SO 4 /KMnO . exhibits high multi‐enzymatic activities acts as catalase (CAT), peroxidase (POD), oxidase (OXD) mimics under acidic conditions. It can regulate TME relieving hypoxia consuming endogenous glutathione (GSH). Glucose (GOx) then incorporated into linked with poly(ethylene glycol) (PEG) to obtain cascade enzyme system (Ce─Mn)‐PEI/GOx‐PEG. CAT‐like properties, which sensitize GOx‐based starvation therapy, POD‐ OXD‐like generate highly cytotoxic reactive oxygen species (ROS) cells. The glucose catabolic product, , also used ROS. addition, structure provides near‐infrared (NIR) photothermal capability, making it suitable therapy (PTT). Density functional theory (DFT) calculations provide possible reasons capability When combining mild PTT (Ce─Mn)‐PEI/GOx‐PEG efficiently ablate tumors.

Язык: Английский

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An iron-based single-atom nanozyme for multiple-channel sensing of epinephrine with wide pH responsivity and intelligence capabilities

Chemical Engineering Journal, Год журнала: 2025, Номер 507, С. 160341 - 160341

Опубликована: Фев. 6, 2025

Язык: Английский

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Cobalt MOF-hybridized nanozyme catalysts breaking pH limitations for boosted chlorpyrifos sensing performance

Food Chemistry, Год журнала: 2025, Номер 475, С. 143399 - 143399

Опубликована: Фев. 12, 2025

Язык: Английский

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Enhancing Peroxidase‐Like Activity and Photothermal Property of Copper Single‐Atom Nanozyme via A Cascade Competition Strategy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Abstract Single‐atom nanozymes (SANs) are promising enzyme‐active catalysts due to their maximum atomic utilization. However, it is still a challenge precisely regulate the single‐atom structure, especially in multimetallic MOFs. Based on Cu‐N 4 structure of Zn Cu 1 , cascade competition strategy mediated by buffer (polydopamine) proposed for first time, which induces one‐step nonthermal reaction remove inactive site and adjust coordination environment. Experimental results theoretical calculations show that nanozyme with 2 O (Cu‐N/O) breaks strong steric restriction, exposed active can better adsorb H making have peroxidase‐like activity. Compared traditional bimetallic (Cu ) monometallic (Cu‐MoF) nanozymes, has stronger catalytic activity photothermal properties, as well good photocatalytic extremely stability. It successfully applied Lateral flow immunoassay achieve three‐mode ultrasensitive detection Escherichia coli O157:H7, test strips after subjected broad‐spectrum sterilization treatment.

Язык: Английский

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Supramolecular Nanozymes Based on Self-Assembly of Biomolecule for Cancer Therapy

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 2043 - 2057

Опубликована: Фев. 1, 2025

Natural enzyme systems possess extraordinary functions and characteristics, making them highly appealing for use in eco-friendly technologies innovative cancer treatments. However, their inherent instability structural complexity often limit practical applications, leading to the exploration of biomolecular nanozyme alternatives. Supramolecular nanozymes, constructed using self-assembly techniques various non-covalent interactions, have emerged as a promising solution. Amino acids, peptides, protein motifs offer flexible building blocks constructing these nanozymes. Importantly, well-defined regulation mechanisms along with unique properties fundamental biological modules living systems-such selectivity, permeability, retention, biocompatibility-present new opportunities therapy. This review highlights recent advances supramolecular self-assembled including peroxidases, oxidases, catalases, superoxide dismutases, other systems, tumor Additionally, it discusses precise functional modulation through interactions therapeutic applications targeting microenvironment. These studies provide valuable insights that may inspire design novel nanozymes enhanced catalytic biocompatibility, tumor-killing efficacy.

Язык: Английский

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Efficient Separation-Free and Wash-Free Immunoassay for Sensitive Detection of Biomarkers Based on the Distance-Driven Chemiluminescent Technique

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

The wash-free method represents a promising strategy for enhancing the detection efficiency of automated chemiluminescent (CL) immunoassay analyzers. Herein, novel separation-free and was developed first time based on distance-driven CL technique. In immunoassay, well-designed Au–Co metal nanoclusters (NCs) exhibited excellent peroxidase-like activity good stability, allowing efficient catalysis luminol or its analogue (ABEI)-H2O2 system even at low concentrations. Furthermore, large specific surface area NCs facilitated accommodation greater number antibodies, thereby capture antigens achieving dual amplification signal. technique relied formation sandwich-type immunocomplexes. Upon generation hydroxyl radicals superoxide anion through catalytic decomposition H2O2 by NCs, ABEI within immunocomplexes could efficiently react with these radicals, leading to significant enhancement in signals. C-reactive protein (CRP) chosen as model analyte evaluate practicability proposed immunoassay. Notably, presented high sensitivity, selectivity, reproducibility, successfully determining CRP serum samples recoveries 96.55–106.29%. Accordingly, advantage separation-free, wash-free, reliable characteristics drastically simplify operation steps enhance efficiency, which would make advances revolution traditional

Язык: Английский

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A twin S-scheme CoFe2O4/VCNDA/BiVO4 nanozyme for photo-auto-enzyme-coupled catalytic degradation of carbamazepine

Chemical Engineering Journal, Год журнала: 2024, Номер 495, С. 153606 - 153606

Опубликована: Июнь 29, 2024

Язык: Английский

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