Fluorescent probes for targeting the Golgi apparatus: design strategies and applications

Chemical Society Reviews, Год журнала: 2024, Номер 53(14), С. 7590 - 7631

Опубликована: Янв. 1, 2024

Golgi-specific fluorescent probes provide non-invasive, real-time and in situ visualization of the temporal spatial fluctuations bioactive species enabling effective disease monitoring treatment.

Язык: Английский

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Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes

Chemical Reviews, Год журнала: 2024, Номер 124(16), С. 9225 - 9375

Опубликована: Авг. 13, 2024

Reactive oxygen and nitrogen species are small reactive molecules derived from elements in the air─oxygen nitrogen. They produced biological systems to mediate fundamental aspects of cellular signaling but must be very tightly balanced prevent indiscriminate damage molecules. Small molecule probes can transmute specific nature each into an observable luminescent signal (or even acoustic wave) offer sensitive selective imaging living cells whole animals. This review focuses specifically on for superoxide, hydrogen peroxide, hypochlorite, nitric oxide, peroxynitrite that provide a or photoacoustic signal. Important background information general photophysical phenomena, common probe designs, mechanisms, modalities will provided, then, analyte thoroughly evaluated. A discussion successes field presented, followed by recommendations improvement future outlook emerging trends. Our objectives informative, useful, thorough guide as well important context compare ecosystem chemistries molecular scaffolds has manifested within field.

Язык: Английский

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A new lysosome-targeted fluorescent probe for hydrogen peroxide based on a benzothiazole derivative

Methods, Год журнала: 2023, Номер 215, С. 38 - 45

Опубликована: Июнь 1, 2023

Язык: Английский

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Quantification and visualization of hydrogen peroxide in an ischemic model and serum samples from stroke patients using a reaction-based fluorescence sensor

Sensors and Actuators B Chemical, Год журнала: 2023, Номер 397, С. 134662 - 134662

Опубликована: Сен. 22, 2023

Язык: Английский

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Anti-oxidants as Therapeutic Agents for Oxidative Stress Associated Pathologies: Future Challenges and Opportunities

Free Radical Research, Год журнала: 2025, Номер unknown, С. 1 - 25

Опубликована: Янв. 7, 2025

Free radicals have been implicated in the pathogenesis of cancer along with cardiovascular, neurodegenerative, pulmonary and inflammatory disorders. Further, relationship between oxidative stress disease is distinctively established. Clinical trials using anti-oxidants for prevention progression indicated some beneficial effects. However, these failed to establish as therapeutic agents due lack efficacy. This attributed fact that living systems are under dynamic redox control wherein their behaviour compartmentalized simple aggregation couples, distributed throughout system, miniscule importance while determining overall state. free radical metabolism intriguingly complex they play plural roles segregated a spatio-temporal manner. Depending on quality, quantity site generation, exhibit or harmful Use non-specific, non-targeted, general ROS scavengers lead systemic elimination all types interferes cellular signaling. Failure act lies this oversimplification extremely environment static non-compartmentalized Rather than generalizing term "oxidative stress" if we can identify "type different diseases, targeted more specific anti-oxidant therapy may be developed. In review, discuss concept dynamics, role type conditions, current status agents. probe possibility developing novel, efficacious drug-like properties.

Язык: Английский

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Coumarin Bialdehyde-Based Fluorescent Probe for the Detection of Hydrazine in Living Cells, Soil Samples and its Application in Test Strips

Опубликована: Янв. 1, 2025

Язык: Английский

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Small-molecule fluorescent probes for detecting hydrogen peroxide in biological systems

Coordination Chemistry Reviews, Год журнала: 2025, Номер 541, С. 216785 - 216785

Опубликована: Май 17, 2025

Язык: Английский

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A novel fluorescent probe for the detection of H2O2 in multiple food matrices and biological samples

Food Chemistry, Год журнала: 2025, Номер unknown, С. 144998 - 144998

Опубликована: Июнь 1, 2025

Язык: Английский

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Coumarin bialdehyde-based fluorescent probe for the detection of hydrazine in living cells, soil samples and its application in test strips

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер unknown, С. 126540 - 126540

Опубликована: Июнь 1, 2025

Язык: Английский

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Unraveling the dual sensing mechanism of hydrogen peroxide probe: Photoinduced electron transfer and unusual local excited state intramolecular proton transfer

Journal of Luminescence, Год журнала: 2023, Номер 267, С. 120387 - 120387

Опубликована: Дек. 15, 2023

Язык: Английский

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