Опубликована: Янв. 1, 2024
Язык: Английский
Опубликована: Янв. 1, 2024
Язык: Английский
Analytical Chemistry, Год журнала: 2024, Номер 96(8), С. 3436 - 3444
Опубликована: Фев. 19, 2024
Cerebral ischemia–reperfusion injury (CIRI), a cause of cerebral dysfunction during infarction treatment, is closely associated with mitochondrial viscosity and hydrogen peroxide (H2O2). However, the accurate measurement H2O2 levels in CIRI challenging because lack sufficient selectivity blood–brain barrier (BBB) penetration existing monitoring tools related to CIRI, hampering exploration role CIRI. To address this issue, we designed an activatable fluorescent probe, mitochondria-targeting styryl-quinolin-ium (Mito-IQS), excellent properties including high selectivity, targeting, BBB penetration, for visualization brain. Based on real-time capabilities bursts were visualized This probe can be used monitor therapeutic effects butylphthalein treatment. More importantly, vivo experiments further confirmed that was levels. discovery provides new insights study expected accelerate process diagnosis, drug design.
Язык: Английский
Процитировано
22TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 174, С. 117684 - 117684
Опубликована: Апрель 2, 2024
Язык: Английский
Процитировано
9Sensors and Actuators B Chemical, Год журнала: 2024, Номер 418, С. 136151 - 136151
Опубликована: Июль 4, 2024
Язык: Английский
Процитировано
7Sensors and Actuators B Chemical, Год журнала: 2024, Номер 410, С. 135646 - 135646
Опубликована: Март 16, 2024
Язык: Английский
Процитировано
4Sensors and Actuators B Chemical, Год журнала: 2024, Номер 419, С. 136419 - 136419
Опубликована: Авг. 4, 2024
Язык: Английский
Процитировано
3Опубликована: Янв. 1, 2025
Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to complexity redundancy within signaling networks in GBM, targeted inhibitors specific pathways have shown only limited success. The nuclear export receptor Chromosome Region Maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, its inhibition can simultaneously disrupt multiple key oncogenic drivers. In this study, we explore whether chromenone derivatives, known for detecting thiol-containing molecules, function CRM1 inhibitors. We synthesized several chromenone-based derivatives demonstrated that they inhibit CRM1-driven structure- dose-dependent manner. A preliminary structure-activity relationship (SAR) was established, providing rationale selective binding based on molecular docking studies. Additionally, showed active effectively endogenous signal (NES)-containing substrates glioblastoma cells. Several these compounds exhibit cytotoxicity against cell lines, highlighting their potential therapies GBM.
Язык: Английский
Процитировано
0Talanta, Год журнала: 2025, Номер 295, С. 128362 - 128362
Опубликована: Май 21, 2025
Язык: Английский
Процитировано
0Food Chemistry, Год журнала: 2025, Номер 489, С. 144998 - 144998
Опубликована: Июнь 3, 2025
Язык: Английский
Процитировано
0Опубликована: Май 14, 2024
Язык: Английский
Процитировано
1Microchemical Journal, Год журнала: 2024, Номер unknown, С. 111742 - 111742
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1