Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
prevalent
cancers,
characterized
by
high
morbidity
and
mortality
rates.
Recently,
immunotherapy
has
emerged
as
a
crucial
treatment
modality
for
HCC,
following
surgery,
locoregional
therapies,
targeted
therapies.
This
approach
harnesses
body's
immune
system
to
target
eliminate
cancer
cells,
potentially
resulting
in
durable
antitumor
responses.
However,
acquired
resistance
tumor
immunosuppressive
microenvironment
(TIME)
significantly
hinder
its
clinical
application.
advancements
nanotechnology,
coupled
with
deeper
understanding
biology
nano-biological
interactions,
have
led
development
various
nanoparticles
aimed
at
enhancing
therapeutic
efficacy
through
specific
targeting
tissues.
These
increase
accumulation
immunotherapeutic
drugs
within
microenvironment,
thereby
transforming
TIME.
In
this
review,
we
provide
concise
overview
fundamental
principles
governing
TIME
landscape
HCC
discuss
rationale
applications
context.
Additionally,
highlight
existing
challenges
potential
opportunities
translation
nanomedicines.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
The
development
of
novel
ladder-type
conjugated
molecules
is
crucial
for
advancing
supramolecular
chemistry
and
material
science.
In
this
study,
we
report
a
straightforward
synthesis
new
alternating
donor-acceptor
(D-A)
heteroarene,
FCDTDPP,
demonstrate
its
application
as
photothermal
agent
imaging
cancer
therapy.
FCDTDPP
constructed
by
vinylene
bridge
between
cyclopentadithiophene
(D)
diketopyrrolopyrrole
(A)
through
intramolecular
Friedel-Crafts
type
reaction.
exhibits
unique
combination
good
molecular
planarity,
efficient
intra-/intermolecular
mixed
D-A
interactions,
local
aromaticity.
These
features
collectively
contribute
to
broad
intense
absorptions
with
narrow
band
gap
in
red
the
spectra,
coupled
multiple
vibrational
absorption
feature,
thereby
enhancing
non-radiative
decay
process
resulting
conversion
property.
nanoparticles
(NPs)
exhibit
superior
performance
stability
under
660
nm
laser
irradiation.
Moreover,
vitro
studies
reveal
that
NPs
possess
excellent
biocompatibility,
low
cytotoxicity,
robust
therapeutic
efficacy,
finding
further
corroborated
preliminary
vivo
experiments
tumor-bearing
mice.
This
work
charts
course
engineering
organic
systems,
propelling
relevant
research
forward.
Bioconjugate Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Single-wavelength
lasers
that
trigger
intelligently
designed
multifunctional
theranostic
nanoplatforms
are
urgently
needed
for
early
cancer
diagnosis
and
imaging-guided
therapy.
In
this
study,
a
novel
zinc
porphyrin,
Por-TR,
was
fabricated
by
incorporating
thiophene
as
donor
introducing
electron
acceptors
on
both
sides
to
expand
the
conjugation.
The
presence
of
multiple
flexible
chains
in
molecular
structure
Por-TR
inhibits
π-π
stacking,
which
allows
it
form
J
nanoaggregates
when
coassembled
with
DSPE-PEG2000,
demonstrating
maximum
absorption
at
approximately
808
nm.
These
NPs
provide
NIR-II
fluorescence/PA
dual-modal
signals
imaging
serve
combined
PTT/PDT
therapeutic
agent,
making
them
suitable
nanoplatform.
To
further
improve
their
effects,
we
embedded
thermosensitive
NO
donor,
BNN6,
nanosystem
achieve
PDT/PTT/NO
Intravenous
injection
Por-TR-NO
into
4T1
tumor-bearing
mice
enabled
accurate
observation
tumor
location
via
imaging.
vivo
therapy
results
show
exhibited
remarkable
antitumor
efficacy
PTT/PDT/NO
therapy,
triggered
an
nm
laser.
Overall,
nanoplatform
offers
versatile
approach
treatment.
