Anionic Heptamethine Cyanine as Reactive Sulfur Species-Activated Probe: Application of NIR-II Fluorescence Imaging for In Vivo Visualization of Glutathione

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137371 - 137371

Опубликована: Фев. 1, 2025

Язык: Английский

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Recent progress in small-molecule fluorescent probes for the detection of superoxide anion, nitric oxide, and peroxynitrite anion in biological systems

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

In this review, we summarized the latest progress (2020–2023) in small-molecule fluorescent probes for monitoring superoxide anion (O 2 ˙ − ), nitric oxide (NO), and peroxynitrite (ONOO ) biological systems.

Язык: Английский

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New AIE Emitters from the Unexpected Boron Tribromide/Boron Trichloride‐mediated Cyclization Reaction and Application for Fluorescence Imaging of Lipid Droplets

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

ABSTRACT The aberrant behavior of lipid droplets (LDs) is often indicative cellular dysfunction, which may contribute to the development a range diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and atherosclerosis (AS). Consequently, there an urgent need develop fluorescence probes targeting LDs monitor progression disease. In this study, unanticipated one‐pot boron tribromide (BBr₃)/boron trichloride (BCl₃)‐promoted cyclization reaction was discovered, yielding bromo‐/chloro‐substituted triphenylamine (TPA) derivative ( TPA‐Br / TPA‐Cl ). successfully transformed into new TPA‐containing donor‐acceptor (D–A) molecules show typical aggregation induced emission (AIE) property. Among these AIE emitters, TPA‐N shows most promising specificity, lowest toxicity best photo‐stability. Ex vivo studies further demonstrate that can be used image fatty AS plaque quickly effectively.

Язык: Английский

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In situ observation of mitochondrial viscosity in liver of mice with drug-induced liver injury by near-infrared fluorescence imaging

Talanta, Год журнала: 2024, Номер 284, С. 127229 - 127229

Опубликована: Ноя. 19, 2024

Язык: Английский

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Rational design of a ratiometric fluorescent probe for selective visualizing peroxynitrite in mitochondria and evaluation of organ injury

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 419, С. 136421 - 136421

Опубликована: Авг. 6, 2024

Язык: Английский

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A novel ultra-sensitive fluorescent probe for monitoring and imaging drug-induced/inhibited ferroptosis-mediated liver injury model via peroxynitrite fluctuations

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112833 - 112833

Опубликована: Янв. 1, 2025

Язык: Английский

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Monitoring Ferroptosis with NIR Fluorescence Probe Capable of Reversible Mitochondria Nucleus Translocation

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Ferroptosis, a recently proposed form of regulated cell death, is characterized by surge in reactive oxygen species and subsequent depletion glutathione. The mitochondria nucleoli play pivotal roles the process ferroptosis. Therefore, monitoring interactions between during ferroptosis crucial for clarifying its physiological pathological processes. In this study, we designed synthesized near-infrared fluorescence probe MINU, which exhibits excellent stability against biological ions pH environments. Due to cationic structure good DNA affinity, MINU can target both nucleoli. Cell imaging demonstrates that reversibly migrate response changes mitochondrial membrane potential. By detecting localization intensity signals, effectively distinguish normal cell, apoptotic ferroptotic cell. Monitoring allows us more accurately appreciate processes

Язык: Английский

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Lipid droplets-targetable fluorescent probe for monitoring polarity changes during ferroptosis

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112879 - 112879

Опубликована: Май 1, 2025

Язык: Английский

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High-Fidelity Spatiotemporal Recognition of Golgi ALP through an Initial-Accumulation and Postactivation Strategy

Analytical Chemistry, Год журнала: 2024, Номер 96(23), С. 9737 - 9743

Опубликована: Июнь 3, 2024

Various signal molecules mediate complex physiological processes collectively in the Golgi. However, most currently accessible probes are questionable illuminating functions of these reactive species Golgi because inability to irradiate only at desired location, which compromises specificity and accuracy. In this study, we rationally designed first photocontrollable Golgi-targeted fluorescent probe situ visualize alkaline phosphatase (ALP). The with natural yellow fluorescence can provide access into monitor exact timing accumulation On-demand photoactivation location affords a significant emission response ALP red 710 nm. Through responsiveness ALP, precise spatiotemporal recognition fluctuations is successfully performed. With probe, for time, revealed levels during cisplatin-induced acute kidney injury (AKI), will further facilitate complement comprehensive exploration kinetics pathological processes.

Язык: Английский

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Simultaneous visualization of lipid droplets and tracking of the endogenous hypochlorous acid in psoriatic mice models with a novel fluorescent probe in a wash-free fashion

Bioorganic Chemistry, Год журнала: 2024, Номер 153, С. 107967 - 107967

Опубликована: Ноя. 16, 2024

Язык: Английский

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