Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Апрель 13, 2023
Diabetic
foot
ulcer
(DFU)
is
considered
the
most
catastrophic
complication
of
diabetes
mellitus
(DM),
leading
to
repeated
hospitalizations,
infection,
gangrene,
and
finally
amputation
limb.
In
patients
suffering
from
mellitus,
wound-healing
process
impaired
due
various
factors
such
as
endothelial
dysfunction
synthesis
advanced
glycation
end-products,
hence,
conventional
therapeutic
interventions
might
not
be
effective.
With
increasing
applications
mesenchymal
stem
cells
(MSCs)
in
recent
years,
their
potential
a
method
for
improving
has
gained
remarkable
attention.
this
field,
exert
beneficial
effects
through
immunomodulation,
differentiation
into
essential
at
site
ulcers,
promoting
angiogenesis,
among
others.
article,
we
review
cellular
molecular
pathways
which
cell
therapy
reinforces
healing
non-healing
ulcers.
Bioactive Materials,
Год журнала:
2023,
Номер
25, С. 347 - 359
Опубликована: Фев. 15, 2023
Periodontitis
is
admittedly
a
microbe-driven
intractable
infectious
disease,
in
which
Porphyromonas
gingivalis
(Pg)
plays
keystone
role.
Pg
can
selectively
impair
the
antimicrobial
responses
of
periodontal
resident
macrophages
including
their
phagocytic
and
bactericidal
activity
without
interfering
proinflammatory
activity,
leads
to
microflora
disturbance,
destructive
inflammation
alveolar
bone
loss
eventually.
Here,
an
injectable
ROS-sensitive
hydrogel
developed
for
releasing
active
marrow-derived
(named
ex-situ
hereafter)
complement
C5a
receptor
antagonist
(C5A)
gingival
crevice.
Through
appropriately
tuning
stiffness,
these
greatly
enhanced,
reaching
optimal
performance
at
elastic
modulus
106
kPa.
Meanwhile,
C5A
avoids
undesired
activation
by
ensure
bacterial
killing
both
in-situ
macrophages.
Besides,
hydrogels
show
another
distinct
feature
decreasing
ROS
level
niche,
contributes
alleviated
attenuated
as
well.
This
study
highlights
potential
utilizing
with
tailored
biomechanical
properties
remodel
functions
therapeutic
cells,
expected
find
wide
applications
even
beyond
periodontitis
treatment.
Abstract
Cell
therapy
has
revolutionized
the
treatment
of
various
diseases,
such
as
cancers,
genetic
disorders,
and
autoimmune
diseases.
Currently,
most
cell
products
rely
on
ex
vivo
engineering,
which
requires
sophisticated
manufacturing
processes
poses
safety
concerns.
The
implementation
in
situ
holds
potential
to
overcome
current
limitations
provides
a
broad
range
applications
clinical
feasibility
future.
A
variety
biomaterials
have
been
developed
improve
function
target
delivery
specific
types
due
their
excellent
biocompatibility,
tunable
properties,
other
functionalities,
provide
reliable
method
achieve
modulation
reprogramming.
In
this
article,
we
summarize
recent
advances
for
including
T
cells,
macrophages,
dendritic
stem
cells
reprogramming
leveraging
lipid
nanoparticles,
polymers,
inorganic
materials,
biomaterials.
Finally,
discuss
challenges
future
perspectives
therapy.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Апрель 13, 2023
Diabetic
foot
ulcer
(DFU)
is
considered
the
most
catastrophic
complication
of
diabetes
mellitus
(DM),
leading
to
repeated
hospitalizations,
infection,
gangrene,
and
finally
amputation
limb.
In
patients
suffering
from
mellitus,
wound-healing
process
impaired
due
various
factors
such
as
endothelial
dysfunction
synthesis
advanced
glycation
end-products,
hence,
conventional
therapeutic
interventions
might
not
be
effective.
With
increasing
applications
mesenchymal
stem
cells
(MSCs)
in
recent
years,
their
potential
a
method
for
improving
has
gained
remarkable
attention.
this
field,
exert
beneficial
effects
through
immunomodulation,
differentiation
into
essential
at
site
ulcers,
promoting
angiogenesis,
among
others.
article,
we
review
cellular
molecular
pathways
which
cell
therapy
reinforces
healing
non-healing
ulcers.
