Cellular Signalling,
Год журнала:
2023,
Номер
109, С. 110794 - 110794
Опубликована: Июль 6, 2023
Traditionally,
mitochondria
are
known
as
"the
powerhouse
of
the
cell,"
responsible
for
energy
(ATP)
generation
(by
electron
transport
chain,
oxidative
phosphorylation,
tricarboxylic
acid
cycle,
and
fatty
ß-oxidation),
regulation
several
metabolic
processes,
including
redox
homeostasis,
calcium
signalling,
cellular
apoptosis.
The
extensive
studies
conducted
in
last
decades
portray
multifaceted
signalling
organelles
that
ultimately
command
cells'
survival
or
death.
Based
on
current
knowledge,
we'll
outline
mitochondrial
to
other
intracellular
compartments
homeostasis
pathology-related
stress
conditions
here.
following
topics
discussed:
(i)
mtROS
mitohormesis,
(ii)
Ca2+
signalling;
(iii)
anterograde
(nucleus-to-mitochondria)
retrograde
(mitochondria-to-nucleus)
signal
transduction,
(iv)
mtDNA
role
immunity
inflammation,
(v)
induction
mitophagy-
apoptosis
-
cascades,
(vi)
dysfunctions
(mitochondriopathies)
cardiovascular,
neurodegenerative,
malignant
diseases.
novel
insights
into
molecular
mechanisms
mitochondria-mediated
can
explain
adaptation
environmental
stresses
achieve
cell
survival.
Molecular Neurodegeneration,
Год журнала:
2023,
Номер
18(1)
Опубликована: Ноя. 11, 2023
Abstract
Mitochondrial
dysfunction
is
strongly
implicated
in
the
etiology
of
idiopathic
and
genetic
Parkinson’s
disease
(PD).
However,
strategies
aimed
at
ameliorating
mitochondrial
dysfunction,
including
antioxidants,
antidiabetic
drugs,
iron
chelators,
have
failed
disease-modification
clinical
trials.
In
this
review,
we
summarize
cellular
determinants
impairment
electron
transport
chain
complex
1,
increased
oxidative
stress,
disturbed
quality
control
mechanisms,
bioenergetic
deficiency.
addition,
outline
pathways
to
neurodegeneration
current
context
PD
pathogenesis,
review
past
treatment
an
attempt
better
understand
why
translational
efforts
thus
far
been
unsuccessful.
Cells,
Год журнала:
2022,
Номер
11(16), С. 2518 - 2518
Опубликована: Авг. 13, 2022
Mitochondria
are
not
only
the
main
energy
supplier
but
also
cell
metabolic
center
regulating
multiple
key
metaborates
that
play
pivotal
roles
in
epigenetics
regulation.
These
metabolites
include
acetyl-CoA,
α-ketoglutarate
(α-KG),
S-adenosyl
methionine
(SAM),
NAD+,
and
O-linked
beta-N-acetylglucosamine
(O-GlcNAc),
which
substrates
for
DNA
methylation
histone
post-translation
modifications,
essential
gene
transcriptional
regulation
fate
determination.
Tumorigenesis
is
attributed
to
many
factors,
including
mutations
tumor
microenvironment.
initiation,
evolution,
metastasis,
recurrence.
Targeting
mitochondrial
metabolism
promising
therapeutic
strategies
treatment.
In
this
review,
we
summarize
of
mitochondria
required
modification
discuss
current
strategy
cancer
therapies
via
targeting
epigenetic
modifiers
related
enzymes
This
review
an
important
contribution
understanding
metabolic-epigenetic-tumorigenesis
concept.
ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 15397 - 15412
Опубликована: Сен. 15, 2022
An
elevated
bone
microenvironmental
reactive
oxygen
species
(ROS)
level
is
a
hallmark
of
osteoporosis
that
often
leads
to
the
dysfunction
bone-related
mesenchymal
stem
cells
(MSCs),
which
would
induce
MSC
senescence
and
severely
undermine
their
osteoblastic
potential.
Herein,
we
report
in
situ
construction
microenvironment-responsive
biofunctional
metal-organic
framework
(bio-MOF)
coating
on
titanium
surface
through
coordination
between
p-xylylenebisphosphonate
(PXBP)
Ce/Sr
ions
by
hydrothermal
method.
Taking
advantage
anchored
Ce
Sr
ions,
AHT-Ce/SrMOF
implants
demonstrate
on-demand
superoxide
dismutase
catalase-like
catalytic
activities
decompose
ROS
MSCs
restore
mitochondrial
functions.
In
vitro
analysis
showed
substantially
activated
AMP-activated
protein
kinase
(AMPK)
signaling
pathway
reduced
levels.
Meanwhile,
grown
displayed
significantly
higher
expressions
fission
marker
(DRP1),
fusion
(MFN2
OPA1),
mitophagy
(PINK1
LC3)
than
those
AHT-CeMOF
AHT-SrMOF
groups,
indicated
bio-MOF
could
amend
function
reverse
senescence.
vivo
evaluations
bio-MOF-coated
Ti
implant
site
promote
new
formation,
leading
improved
osteointegration
osteoporotic
rat.
This
study
may
improve
implant-mediated
fracture
healing
clinics.
Chemical Reviews,
Год журнала:
2023,
Номер
123(10), С. 6612 - 6667
Опубликована: Апрель 18, 2023
The
gold
drugs,
sodium
thiomalate
(Myocrisin),
aurothioglucose
(Solganal),
and
the
orally
administered
auranofin
(Ridaura),
are
utilized
in
modern
medicine
for
treatment
of
inflammatory
arthritis
including
rheumatoid
juvenile
arthritis;
however,
new
agents
have
been
slow
to
enter
clinic.
Repurposing
different
disease
indications
such
as
cancer,
parasitic,
microbial
infections
clinic
has
provided
impetus
development
complexes
biomedical
applications
based
on
unique
mechanistic
insights
differentiated
from
auranofin.
Various
chemical
methods
preparation
physiologically
stable
associated
mechanisms
explored
biomedicine
therapeutics
or
probes.
In
this
Review,
we
discuss
chemistry
next
generation
which
encompasses
oxidation
states,
geometry,
ligands,
coordination,
organometallic
compounds
infectious
diseases,
inflammation,
tools
biology
via
gold-protein
interactions.
We
will
focus
within
past
decade.
Review
provides
readers
with
an
accessible
overview
utility,
development,
mechanism
action
gold-based
small
molecules
establish
context
basis
thriving
resurgence
medicine.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 24, 2024
Abstract
Aging
is
a
complex
and
multifaceted
process
involving
variety
of
interrelated
molecular
mechanisms
cellular
systems.
Phenotypically,
the
biological
aging
accompanied
by
gradual
loss
function
systemic
deterioration
multiple
tissues,
resulting
in
susceptibility
to
aging-related
diseases.
Emerging
evidence
suggests
that
closely
associated
with
telomere
attrition,
DNA
damage,
mitochondrial
dysfunction,
nicotinamide
adenine
dinucleotide
levels,
impaired
macro-autophagy,
stem
cell
exhaustion,
inflammation,
protein
balance,
deregulated
nutrient
sensing,
altered
intercellular
communication,
dysbiosis.
These
age-related
changes
may
be
alleviated
intervention
strategies,
such
as
calorie
restriction,
improved
sleep
quality,
enhanced
physical
activity,
targeted
longevity
genes.
In
this
review,
we
summarise
key
historical
progress
exploration
important
causes
anti-aging
strategies
recent
decades,
which
provides
basis
for
further
understanding
reversibility
phenotypes,
application
prospect
synthetic
biotechnology
therapy
also
prospected.
Cell Reports,
Год журнала:
2023,
Номер
42(2), С. 112033 - 112033
Опубликована: Янв. 31, 2023
Cell
plasticity
and
neuroendocrine
differentiation
in
prostate
lung
adenocarcinomas
are
one
of
the
major
reasons
for
therapeutic
resistance
to
targeted
therapy.
Whether
how
metabolic
changes
contribute
this
adenocarcinoma-to-neuroendocrine
cell
fate
transition
remains
largely
unclear.
Here
we
show
that
or
cancer
cells
possess
mostly
fragmented
mitochondria
with
low
membrane
potential
rely
on
glycolysis
energy
metabolism.
We
further
an
important
role
determinant
Numb
mitochondrial
quality
control
via
binding
Parkin
facilitating
Parkin-mediated
mitophagy.
Deficiency
Numb/Parkin
pathway
causes
a
reprogramming
featured
significant
increase
production
lactate
acid,
which
subsequently
leads
upregulation
histone
lactylation
transcription
neuroendocrine-associated
genes.
Collectively,
Numb/Parkin-directed
fitness
is
key
switch
promising
target
through
regulation
lactylation.
