Simultaneous Activation of Immunogenic Cell Death and cGAS-STING Pathway by Liver- and Mitochondria-Targeted Gold(I) Complexes for Chemoimmunotherapy of Hepatocellular Carcinoma

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(3), С. 1982 - 2003

Опубликована: Янв. 23, 2024

Induction of immunogenic cell death (ICD) and activation the cyclic GMP-AMP synthase stimulator interferon gene (cGAS-STING) pathway are two potent anticancer immunotherapeutic strategies in hepatocellular carcinoma (HCC). Herein, 12 liver- mitochondria-targeting gold(I) complexes (

Язык: Английский

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Gold(I)-Organic Frameworks as Catalysts for Carboxylation of Alkynes with CO₂

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(41), С. 22720 - 22727

Опубликована: Окт. 4, 2023

Construction of gold-based metal-organic frameworks (Au-MOFs) would bring the merits gold chemistry into MOFs. However, it still remains challenging because cations are easily reduced to metallic under solvothermal conditions. Herein, we present first example Au-MOFs prepared from networking cyclic trinuclear gold(I) complexes by formal transimination reaction in a rapid (<15 min) and scalable (up 1 g) fashion ambient condition. The feature uniform porosity, high crystallinity, superior chemical stability toward base (i.e., 20 M NaOH). With open Au(I) sites skeleton, as heterogeneous catalysts delivered good performance substrate tolerance for carboxylation reactions alkynes with CO2. This work demonstrates facile approach reticularly synthesize combining coordination dynamic covalent chemistry.

Язык: Английский

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The Therapeutic Potential in Cancer of Terpyridine‐Based Metal Complexes Featuring Group 11 Elements

ChemMedChem, Год журнала: 2024, Номер 19(10)

Опубликована: Фев. 8, 2024

Abstract Terpyridine‐based complexes with group 11 metals emerge as potent metallodrugs in cancer therapy. This comprehensive review focuses on the current landscape of anticancer examples, particularly highlighting mechanisms action. While Cu(II) complexes, featuring diverse ancillary ligands, dominate field, exploration silver and gold species remains limited. These exhibit significant cytotoxicity against various cell lines a commendable selectivity for non‐tumorigenic cells. DNA interactions, employing intercalation groove binding, are pivotal finely tuned through terpyridine ligand functionalization. In addition, copper showcase nuclease activity, triggering apoptosis ROS generation. Despite silver‘s high affinity nitrogen donor atoms, its is relatively sparse, indications acting intercalating agents causing hydrolytic cleavage. Gold(III) compounds, overshadowing gold(I) due to stability concerns, not only intercalate but also induce disrupt mitochondrial membrane. Further investigations needed fully understand mechanism action these necessity exploring additional biological targets promising metallodrugs.

Язык: Английский

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Phthalocyanine self-assembled nanoparticles for type I photodynamic antibacterial therapy

Chinese Chemical Letters, Год журнала: 2024, Номер 35(12), С. 109522 - 109522

Опубликована: Янв. 28, 2024

Язык: Английский

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Synthesis and luminescent properties of hetero-bimetallic and hetero-trimetallic Ru(ii)/Au(i) or Ir(iii)/Au(i) complexes

Dalton Transactions, Год журнала: 2024, Номер 53(9), С. 4165 - 4174

Опубликована: Янв. 1, 2024

Luminescent, heterometallic species based on [Ru–Au] 3+ , [Ru–Au 2 ] 4+ [Ir–Au] 2+ and [Ir–Au .

Язык: Английский

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Auranofin-Loaded Chitosan Nanoparticles Demonstrate Potency against Triple-Negative Breast Cancer

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(3), С. 2012 - 2022

Опубликована: Март 7, 2024

Triple-negative breast cancer (TNBC) remains a clinical challenge due to molecular, metabolic, and genetic heterogeneity as well the lack of validated drug targets. Thus, therapies or delivery paradigms are needed. Gold-derived compounds including FDA-approved drug, auranofin have shown promise effective anticancer agents against several tumors. To improve solubility bioavailability auranofin, we hypothesized that nanodelivery using biodegradable chitosan modified polyethylene glycol (PEG) nanoparticles (NPs) will enhance activity TNBC by comparing best nanoformulation with free drug. The selection was based on synthesis various PEG copolymers via formaldehyde-mediated engraftment onto form [chitosan-g-PEG] copolymer. Furthermore, altered physiochemical properties copolymer formaldehyde ratio towards (CP 1–4 NPs). Following recruitment polymer surface, explored how this process influenced stiffness nanoparticle atomic force microscopy (AFM), factor crucial for in vitro vivo studies. Our objective ensure full functionality inherent parent maintained without allowing overshadow chitosan's unique cationic while improving neutral pH. Hence, CP 2 NP chosen. demonstrate efficacy good carrier administered dose 3 mg/kg contrast which given at 5 mg/kg. In studies revealed potency encapsulated cells severe necrotic effect following treatment superior auranofin. conclusion, chitosan-g-PEG potential be an excellent system increasing its effectiveness potentially reducing limitations.

Язык: Английский

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Ion Pairing Enables Targeted Prodrug Activation via Red Light Photocatalysis: A Proof-of-Concept Study with Anticancer Gold Complexes

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(12), С. 8547 - 8556

Опубликована: Март 18, 2024

Photocatalysis has found increasing applications in biological systems, for example, localized prodrug activation; however, high-energy light is usually required without giving sufficient efficiency and target selectivity. In this work, we report that ion pairing between photocatalysts prodrugs can significantly improve the photoactivation enable tumor-targeted activation by red light. This exemplified a gold-based (1d) functionalized with morpholine moiety. Such modification causes 1d to hydrolyze aqueous solution, forming cationic species tightly interacts anionic photosensitizers including Eosin Y (EY) Rose Bengal (RB), along significant bathochromic shift of absorption tailing far-red region. As result, high EY or RB under low-energy was found, leading an effective release active gold living cells, as monitored gold-specific biosensor (GolS-mCherry). Importantly, moiety, pKa ∼6.9, brings highly pH-sensitive preferential ionic interaction slightly acidic condition over normal physiological pH, enabling irradiation vitro vivo. Since similar change other morpholine/amine-containing clinic drugs, photocages, precursors reactive labeling intermediates, it believed ion-pairing strategy could be extended targeted different mapping microenvironment

Язык: Английский

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Programmable melanoma-targeted radio-immunotherapy via fusogenic liposomes functionalized with multivariate-gated aptamer assemblies

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 12, 2024

Radio-immunotherapy exploits the immunostimulatory features of ionizing radiation (IR) to enhance antitumor effects and offers emerging opportunities for treating invasive tumor indications such as melanoma. However, insufficient dose deposition immunosuppressive microenvironment (TME) solid tumors limit its efficacy. Here we report a programmable sequential therapeutic strategy based on multifunctional fusogenic liposomes (Lip@AUR-ACP-aptPD-L1) overcome intrinsic radio-immunotherapeutic resistance tumors. Specifically, are loaded with gold-containing Auranofin (AUR) inserted multivariate-gated aptamer assemblies (ACP) PD-L1 aptamers in lipid membrane, potentiating melanoma-targeted AUR delivery while transferring ACP onto cell surface through selective membrane fusion. amplifies IR-induced immunogenic death melanoma cells release antigens damage-associated molecular patterns adenosine triphosphate (ATP) triggering adaptive immunity. AUR-sensitized radiotherapy also upregulates matrix metalloproteinase-2 (MMP-2) expression that combined released ATP activate an "and" logic operation-like process (AND-gate), thus in-situ engineered cytosine-phosphate-guanine aptamer-based immunoadjuvants (eCpG) stimulating dendritic cell-mediated T priming. Furthermore, inhibits tumor-intrinsic vascular endothelial growth factor signaling suppress infiltration fostering anti-tumorigenic TME. This study approach treatment clinics.

Язык: Английский

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Antibiotics: A “GOLDen” promise?

Coordination Chemistry Reviews, Год журнала: 2023, Номер 500, С. 215429 - 215429

Опубликована: Ноя. 6, 2023

Язык: Английский

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Efficient gold recovery from low concentrated Au(S2O3)23− solution through enhanced photocatalysis via photothermal and surface plasmon resonance assistance on MoS2/MXene/Ag

Desalination, Год журнала: 2024, Номер 584, С. 117733 - 117733

Опубликована: Май 9, 2024

Язык: Английский

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