Biomedical Physics & Engineering Express,
Год журнала:
2024,
Номер
10(5), С. 052002 - 052002
Опубликована: Авг. 14, 2024
Abstract
Purpose
.
This
review
aims
to
highlight
current
improvements
in
microfluidic
devices
designed
for
digestive
cancer
simulation.
The
emphasizes
the
use
of
multicellular
3D
tissue
engineering
models
understand
complicated
biology
tumor
microenvironment
(TME)
and
progression.
purpose
is
develop
oncology
research
improve
patients’
lives.
Methods
analyzes
recent
on
mimicking
cancer.
It
uses
tissue-engineered
devices,
notably
organs
a
chip
(OOC),
simulate
human
organ
function
lab.
Cell
cultivation
modern
three-dimensional
hydrogel
platforms
allows
precise
geometry,
biological
components,
physiological
qualities.
novel
methodologies,
key
findings,
technical
progress
explain
this
field’s
advances.
Results
study
discusses
advances
Micro
systems
with
are
emphasized.
These
capture
complex
biochemical
gradients,
niche
variables,
dynamic
cell–cell
interactions
(TME).
reveal
stomach
progression
by
duplicating
TME.
Recent
discoveries
technology
have
improved
our
understanding
gut
biology,
as
shown
review.
Conclusion
Microfluidic
play
crucial
role
modeling
furthering
research.
could
transform
drug
development
treatment
revealing
provides
complete
summary
suggests
future
field
professionals.
review’s
major
goal
further
medical
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(21)
Опубликована: Июль 22, 2023
Organoids
and
cells
in
organ-on-chip
platforms
replicate
higher-level
anatomical,
physiological,
or
pathological
states
of
tissues
organs.
These
technologies
are
widely
regarded
by
academia,
the
pharmacological
industry
regulators
as
key
biomedical
developments.
To
map
advances
this
emerging
field,
a
literature
analysis
16,000
article
metadata
based
on
quality-controlled
text-mining
algorithm
is
performed.
The
covers
titles,
keywords,
abstracts
categorized
academic
publications
preprint
databases
published
after
2010.
identifies
tracks
149
107
organs
organ
substructures
modeled
organoids
organ-on-chip,
respectively,
stem
cell
sources,
well
130
diseases,
16
groups
organisms
other
than
human
mouse
which
organoid/organ-on-chip
technology
applied.
illustrates
changing
diversity
focus
research
captures
its
geographical
distribution.
downloadable
dataset
provided
robust
framework
for
researchers
to
interrogate
with
their
own
questions.
Theranostics,
Год журнала:
2024,
Номер
14(8), С. 3300 - 3316
Опубликована: Янв. 1, 2024
Patient-derived
organoids
(PDOs)
have
emerged
as
a
promising
platform
for
clinical
and
translational
studies.
A
strong
correlation
exists
between
outcomes
the
use
of
PDOs
to
predict
efficacy
chemotherapy
and/or
radiotherapy.
To
standardize
interpretation
enhance
scientific
communication
in
field
cancer
precision
medicine,
we
revisit
concept
PDO-based
drug
sensitivity
testing
(DST).
We
present
an
expert
consensus-driven
approach
medication
selection
aimed
at
predicting
patient
responses.
further
DST,
propose
guidelines
clarification
characterization.
Additionally,
identify
several
major
challenges
prediction
when
utilizing
PDOs.
Biomedical Physics & Engineering Express,
Год журнала:
2024,
Номер
10(5), С. 052002 - 052002
Опубликована: Авг. 14, 2024
Abstract
Purpose
.
This
review
aims
to
highlight
current
improvements
in
microfluidic
devices
designed
for
digestive
cancer
simulation.
The
emphasizes
the
use
of
multicellular
3D
tissue
engineering
models
understand
complicated
biology
tumor
microenvironment
(TME)
and
progression.
purpose
is
develop
oncology
research
improve
patients’
lives.
Methods
analyzes
recent
on
mimicking
cancer.
It
uses
tissue-engineered
devices,
notably
organs
a
chip
(OOC),
simulate
human
organ
function
lab.
Cell
cultivation
modern
three-dimensional
hydrogel
platforms
allows
precise
geometry,
biological
components,
physiological
qualities.
novel
methodologies,
key
findings,
technical
progress
explain
this
field’s
advances.
Results
study
discusses
advances
Micro
systems
with
are
emphasized.
These
capture
complex
biochemical
gradients,
niche
variables,
dynamic
cell–cell
interactions
(TME).
reveal
stomach
progression
by
duplicating
TME.
Recent
discoveries
technology
have
improved
our
understanding
gut
biology,
as
shown
review.
Conclusion
Microfluidic
play
crucial
role
modeling
furthering
research.
could
transform
drug
development
treatment
revealing
provides
complete
summary
suggests
future
field
professionals.
review’s
major
goal
further
medical
