Muscles,
Год журнала:
2023,
Номер
2(2), С. 119 - 163
Опубликована: Март 24, 2023
Musculoskeletal
health
is
directly
linked
to
independence
and
longevity,
but
disease
aging
impairs
muscle
mass
health.
Complete
repair
after
a
pathological
or
physiological
injury
critical
for
maintaining
function,
yet
compromised
disuse,
in
conditions
such
as
metabolic
diseases,
cancer,
aging.
Regeneration
of
damaged
tissue
critically
dependent
upon
achieving
the
optimal
function
satellite
cells
(muscle
stem
cells,
MSCs).
MSC
remodeling
highly
its
microenvironment,
MSCs,
which
on
functional
capacity
their
mitochondria.
Muscle
energy
demanding
mitochondria
provide
primary
source
production
during
regeneration.
However,
induce
mitochondrial
dysfunction,
limits
Nevertheless,
role
likely
extends
beyond
ATP
could
potentially
important
regulatory
signaling
MSCs
from
injury.
The
scope
current
research
regeneration
molecules
exosomes,
largely
with
goal
understanding
ways
improve
function.
This
review
focuses
skeletal
myogenesis/regeneration
repair.
A
therapeutic
strategy
improving
number
will
be
discussed
means
enhancing
Highlights:
(a).
Mitochondrial
dysfunction
regeneration;
(b).
cell
(MSC)
can
modulated
by
mitochondria;
(c).
Enhancing
may
an
Cells,
Год журнала:
2024,
Номер
13(3), С. 255 - 255
Опубликована: Янв. 30, 2024
Understanding
the
intricate
mechanisms
governing
cellular
response
to
resistance
exercise
is
paramount
for
promoting
healthy
aging.
This
narrative
review
explored
age-related
alterations
in
recovery
from
exercise,
focusing
on
nuanced
aspects
of
exercise-induced
muscle
damage
older
adults.
Due
limited
number
studies
adults
that
attempt
delineate
age
differences
discovery,
we
delve
into
multifaceted
influences
chronic
low-grade
inflammation,
modifications
extracellular
matrix,
and
role
lipid
mediators
shaping
landscape
aging
skeletal
muscle.
From
our
literature
search,
it
evident
aged
displays
delayed,
prolonged,
inefficient
recovery.
These
changes
can
be
attributed
anabolic
resistance,
stiffening
mitochondrial
dysfunction,
unresolved
inflammation
as
well
satellite
cell
function.
Collectively,
these
impairments
may
impact
subsequent
adaptations
exercise.
Insights
gleaned
this
exploration
inform
targeted
interventions
aimed
at
enhancing
efficacy
training
programs
tailored
specific
needs
adults,
ultimately
fostering
preserving
functional
independence.
