Abstract
Hematopoiesis
unfolds
within
the
bone
marrow
niche
where
hematopoietic
stem
cells
(HSCs)
play
a
central
role
in
continually
replenishing
blood
cells.
The
hypoxic
environment
imparts
peculiar
metabolic
characteristics
to
processes.
Here,
we
discuss
internal
metabolism
of
HSCs
and
describe
external
influences
exerted
on
HSC
by
environment.
Importantly,
suggest
that
cues
are
intertwined
with
cell
fate,
crucial
for
Metabolic
dysregulation
during
acute
stress,
inflammation,
chronic
inflammatory
conditions
can
lead
reduced
vitality.
Additionally,
raise
questions
regarding
stresses
imposed
implementation
protocols
such
as
allo‐SCT
gene
therapy,
potential
ramifications.
Enhancing
our
comprehension
will
expand
understanding
pathophysiology
improve
application
therapies.
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107589 - 107589
Опубликована: Янв. 1, 2025
Bone
marrow
hematopoietic
injury
encompasses
a
range
of
pathological
conditions
that
disrupt
the
normal
function
system,
primarily
through
impaired
production
and
differentiation
bone
cells.
Key
pathogenic
mechanisms
include
aging,
radiation
damage,
chemical
induction,
infection
inflammation,
cross-talk
with
non-hematopoietic
diseases.
These
factors
often
lead
to
myelosuppression
myeloid
skewing.
Furthermore,
we
explored
potential
application
prospects
natural
products
in
treatment
injury.
Natural
products,
particularly
those
derived
from
Chinese
herbal
medicines
other
sources,
have
emerged
as
promising
therapeutic
options
due
their
distinctive
minimal
side
effects.
A
deeper
understanding
underlying
could
illuminate
how
exert
effects,
thereby
optimizing
strategies
offering
safer,
more
effective
for
patients.
Future
research
should
leverage
emerging
technologies
further
elucidate
composition
interactions
within
microenvironment,
well
specific
pathways
which
modulate
dysfunction.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 671 - 671
Опубликована: Янв. 14, 2025
Human
hematopoietic
stem
cells
(HSCs)
have
traditionally
been
viewed
as
self-renewing,
multipotent
with
enormous
potential
in
sustaining
essential
steady
state
blood
and
immune
cell
production
throughout
life.
Indeed,
around
86%
(1011-1012)
of
new
generated
daily
a
healthy
young
human
adult
are
origin.
Therapeutically,
HSCs
contributed
to
over
1.5
million
transplants
(HCTs)
globally,
making
this
the
most
successful
regenerative
therapy
date.
We
will
commence
review
by
briefly
highlighting
selected
key
achievements
(from
1868
end
20th
century)
that
accomplishment.
Much
our
knowledge
hematopoiesis
is
based
on
small
animal
models
that,
despite
their
importance,
do
not
always
recapitulate
hematopoiesis.
Given
this,
we
critically
progress
challenges
faced
identifying
tracing
lineage
differentiation
trajectories,
referring
murine
studies
needed.
Moving
forward
given
dynamic
can
readily
adjust
variety
stressors,
then
discuss
recent
research
advances
contributing
understanding
(i)
which
HSPCs
maintain
hematopoiesis,
(ii)
where
these
located,
(iii)
mechanisms
come
into
play
when
homeostatic
switches
stress-induced
or
emergency
Journal of Clinical Investigation,
Год журнала:
2024,
Номер
134(15)
Опубликована: Июль 31, 2024
Clonal
hematopoiesis
of
indeterminate
potential
(CHIP)
is
characterized
by
the
selective
expansion
hematopoietic
stem
and
progenitor
cells
(HSPCs)
carrying
somatic
mutations.
While
CHIP
typically
asymptomatic,
it
has
garnered
substantial
attention
due
to
its
association
with
pathogenesis
multiple
disease
conditions,
including
cardiovascular
(CVD)
hematological
malignancies.
In
this
Review,
we
will
discuss
seminal
recent
studies
that
have
advanced
our
understanding
mechanisms
drive
selection
for
mutant
HSPCs
in
BM
niche.
Next,
address
evaluating
relationships
between
clonal
dynamics
development
across
lifespan.
examine
roles
systemic
factors
can
influence
cell
(HSC)
fitness,
inflammation,
exposures
cytotoxic
agents
driving
clones.
Furthermore,
consider
how
-
through
their
impact
on
niche
lifestyle
factors,
diet,
exercise,
psychosocial
stressors,
might
contribute
process
evolution
culminates
CHIP.
Finally,
review
role
old
age
as
a
major
driver
