How age affects human hematopoietic stem and progenitor cells and strategies to mitigate HSPC aging

Experimental Hematology, Год журнала: 2025, Номер unknown, С. 104711 - 104711

Опубликована: Янв. 1, 2025

Язык: Английский

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Redox regulation: mechanisms, biology and therapeutic targets in diseases

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 7, 2025

Redox signaling acts as a critical mediator in the dynamic interactions between organisms and their external environment, profoundly influencing both onset progression of various diseases. Under physiological conditions, oxidative free radicals generated by mitochondrial respiratory chain, endoplasmic reticulum, NADPH oxidases can be effectively neutralized NRF2-mediated antioxidant responses. These responses elevate synthesis superoxide dismutase (SOD), catalase, well key molecules like nicotinamide adenine dinucleotide phosphate (NADPH) glutathione (GSH), thereby maintaining cellular redox homeostasis. Disruption this finely tuned equilibrium is closely linked to pathogenesis wide range Recent advances have broadened our understanding molecular mechanisms underpinning dysregulation, highlighting pivotal roles genomic instability, epigenetic modifications, protein degradation, metabolic reprogramming. findings provide foundation for exploring regulation mechanistic basis improving therapeutic strategies. While antioxidant-based therapies shown early promise conditions where stress plays primary pathological role, efficacy diseases characterized complex, multifactorial etiologies remains controversial. A deeper, context-specific signaling, particularly redox-sensitive proteins, designing targeted aimed at re-establishing balance. Emerging small molecule inhibitors that target specific cysteine residues proteins demonstrated promising preclinical outcomes, setting stage forthcoming clinical trials. In review, we summarize current intricate relationship disease also discuss how these insights leveraged optimize strategies practice.

Язык: Английский

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Unraveling the pathogenesis of bone marrow hematopoietic injury and the therapeutic potential of natural products

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107589 - 107589

Опубликована: Янв. 1, 2025

Bone marrow hematopoietic injury encompasses a range of pathological conditions that disrupt the normal function system, primarily through impaired production and differentiation bone cells. Key pathogenic mechanisms include aging, radiation damage, chemical induction, infection inflammation, cross-talk with non-hematopoietic diseases. These factors often lead to myelosuppression myeloid skewing. Furthermore, we explored potential application prospects natural products in treatment injury. Natural products, particularly those derived from Chinese herbal medicines other sources, have emerged as promising therapeutic options due their distinctive minimal side effects. A deeper understanding underlying could illuminate how exert effects, thereby optimizing strategies offering safer, more effective for patients. Future research should leverage emerging technologies further elucidate composition interactions within microenvironment, well specific pathways which modulate dysfunction.

Язык: Английский

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Metabolism and metabolites regulating hematopoiesis

Current Opinion in Immunology, Год журнала: 2025, Номер 93, С. 102525 - 102525

Опубликована: Янв. 18, 2025

Язык: Английский

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Metabolic landscape and rewiring in normal hematopoiesis, leukemia and aging

Seminars in Cancer Biology, Год журнала: 2025, Номер 111, С. 1 - 15

Опубликована: Фев. 9, 2025

Язык: Английский

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Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus

Bone Research, Год журнала: 2025, Номер 13(1)

Опубликована: Март 3, 2025

Abstract Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus (T2DM), which is characterized by suppressed osteoblast function disrupted bone microarchitecture. In this study, we utilized male C57BL/6 J mice to investigate the role of SIRT3 T2DM. Decreased expression impaired mitochondrial quality control mechanism are observed both vitro vivo models Mechanistically, suppression results hyperacetylation FOXO3, hindering activation PINK1/PRKN mediated mitophagy pathway resulting accumulation dysfunctional mitochondria. Genetical overexpression or pharmacological restores deacetylation status thus facilitating ameliorating osteogenic impairment Collectively, our findings highlight fundamental regulatory control, crucial for maintaining homeostasis These insights not only enhance understanding molecular mechanisms underlying diabetic osteoporosis but also identify as promising therapeutic target osteoporosis.

Язык: Английский

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Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow

Nature Aging, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Язык: Английский

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A comparison study on compounding oat β-glucan onto Pleurotus eryngii protein by using different methods: In vitro digestion and fermentation characteristics

Food Hydrocolloids, Год журнала: 2024, Номер 160, С. 110848 - 110848

Опубликована: Ноя. 15, 2024

Язык: Английский

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Metabolic regulation in normal and leukemic stem cells

Trends in Pharmacological Sciences, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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