Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1133 - 1133
Опубликована: Ноя. 10, 2024
Unlike enriched environments for rodents, human-built often hinder neuroplasticity through sedentary lifestyles, to which exercise can merely overcome its adverse effects. This paper introduces "environmental affordance physical activity" quantify the potential of spatial layout designs stimulate activity and sustain neuroplasticity, mainly hippocampal neurogenesis.
Язык: Английский
Nature Reviews Molecular Cell Biology, Год журнала: 2022, Номер 24(1), С. 45 - 62
Опубликована: Июль 20, 2022
Язык: Английский
Процитировано
230
Ageing Research Reviews, Год журнала: 2022, Номер 78, С. 101636 - 101636
Опубликована: Апрель 29, 2022
Язык: Английский
Процитировано
125
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Окт. 23, 2023
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in hippocampus and formation amyloid plaques, hyperphosphorylated tau protein, neurofibrillary tangles brain. The overexpression amyloid-β precursor protein (APP) an AD brain results binding APP intracellular domain (AICD) to Fe65 via C-terminal Fe65-PTB2 interaction, which then triggers secretion consequent pathogenesis AD. Apparently, targeting interaction between can offer promising therapeutic approach for Recently, exosome, type extracellular vesicle with diameter around 30–200 nm, has gained much attention as potential delivery tool diseases, including AD, due their ability cross blood–brain barrier, efficient uptake autologous cells, be surface-modified target-specific receptor ligands. Here, engineering neuron cell-derived exosomes overexpress Fe65, enabled development novel exosome-based targeted drug system, carried Corynoxine-B (Cory-B, autophagy inducer) overexpressed-neuron cells mice. Fe65-engineered HT22 (Fe65-EXO) loaded Cory-B (Fe65-EXO-Cory-B) hijacked signaling blocked natural APP, enabling APP-targeted Cory-B. Notably, Fe65-EXO-Cory-B induced APP-expressing neuronal leading amelioration cognitive decline mice, demonstrating effective intervention
Язык: Английский
Процитировано
58
Brain Sciences, Год журнала: 2023, Номер 13(12), С. 1610 - 1610
Опубликована: Ноя. 21, 2023
Neuroplasticity refers to the ability of brain reorganize and modify its neural connections in response environmental stimuli, experience, learning, injury, disease processes. It encompasses a range mechanisms, including changes synaptic strength connectivity, formation new synapses, alterations structure function neurons, generation neurons. plays crucial role developing maintaining function, learning memory, as well recovery from injury adaptation changes. In this review, we explore vast potential neuroplasticity various aspects across lifespan context disease. Changes aging significance cognitive later life will also be reviewed. Finally, discuss common mechanisms associated with age-related neurodegenerative processes (including protein aggregation accumulation, mitochondrial dysfunction, oxidative stress, neuroinflammation) how these can mitigated, at least partially, by non-invasive non-pharmacologic lifestyle interventions aimed promoting harnessing neuroplasticity.
Язык: Английский
Процитировано
53
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 239, С. 124231 - 124231
Опубликована: Март 28, 2023
Язык: Английский
Процитировано
46
Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)
Опубликована: Фев. 2, 2024
Abstract Neuroinflammation is a pathological hallmark of Alzheimer’s disease (AD), characterized by the stimulation resident immune cells brain and penetration peripheral cells. These inflammatory processes facilitate deposition amyloid-beta (Aβ) plaques abnormal hyperphosphorylation tau protein. Managing neuroinflammation to restore homeostasis decrease neuronal damage therapeutic approach for AD. One way achieve this through exercise, which can improve function protect against neuroinflammation, oxidative stress, synaptic dysfunction in AD models. The neuroprotective impact exercise regulated various molecular factors that be activated same as administration their mimetics. Recent evidence has proven some mimetics effective alleviating AD, and, additionally, they are helpful alternative option patients who unable perform regular physical manage neurodegenerative disorders. This review focuses on current state knowledge mimetics, including efficacy, regulatory mechanisms, progress, challenges, limitations, future guidance application therapy.
Язык: Английский
Процитировано
21
Biomedicines, Год журнала: 2022, Номер 10(5), С. 1206 - 1206
Опубликована: Май 23, 2022
Astrocytes are essential for normal brain development and functioning. They respond to injury disease through a process referred as reactive astrogliosis, where the reactivity is highly heterogenous context-dependent. Reactive astrocytes active contributors pathology can exert beneficial, detrimental, or mixed effects following insults. Transforming growth factor-β (TGF-β) has been identified one of key factors regulating astrocyte reactivity. The genetic pharmacological manipulation TGF-β signaling pathway in animal models central nervous system (CNS) alters pathological functional outcomes. This review aims provide recent understanding regarding injury, aging, neurodegeneration. Further, it explores how modulates function context CNS injury.
Язык: Английский
Процитировано
63
The Annual Review of Pharmacology and Toxicology, Год журнала: 2021, Номер 62(1), С. 255 - 277
Опубликована: Окт. 12, 2021
Neurodegenerative diseases are characterized by the loss of homeostatic functions that control redox and energy metabolism, neuroinflammation, proteostasis. The transcription factor nuclear erythroid 2–related 2 (NRF2) is a master controller these functions, its overall activity compromised during aging in diseases. However, NRF2 can be activated pharmacologically now being considered common therapeutic target. Many gaps still exist our knowledge specific role plays specialized brain cell or how cells respond to hallmarks This review discusses relevance several hallmark features neurodegenerative current status pharmacological activators might pass through blood-brain barrier provide disease-modifying effect.
Язык: Английский
Процитировано
61
Brain Plasticity, Год журнала: 2022, Номер 8(1), С. 97 - 119
Опубликована: Сен. 30, 2022
The birth, maturation, and integration of new neurons in the adult hippocampus regulates specific learning memory processes, responses to stress, antidepressant treatment efficacy. This process hippocampal neurogenesis is sensitive environmental stimuli, including peripheral signals from certain cytokines, hormones, metabolites, which can promote or hinder production survival neurons. trillions microorganisms resident gastrointestinal tract, collectively known as gut microbiota, also demonstrate ability modulate neurogenesis. In doing so, microbiota-gut-brain axis influence brain functions regulated by Unlike hippocampus, microbiota highly accessible direct interventions, such prebiotics, probiotics, antibiotics, be manipulated lifestyle choices diet. Therefore, understanding pathways shapes may reveal novel targets for non-invasive therapeutics treat disorders alterations have been implicated. review first outlines factors both microbiome neurogenesis, with cognizance that these effects might happen either independently due microbiota-driven mechanisms. We then highlight approaches investigating regulation axis. Finally, we summarize current evidence demonstrating microbiota's mechanisms driven through immune pathways, microbial endocrine signalling, nervous system, postulate implications disease onset treatment.
Язык: Английский
Процитировано
50
Neural Regeneration Research, Год журнала: 2023, Номер 19(3), С. 619 - 628
Опубликована: Июль 28, 2023
Abstract Recent studies have demonstrated that neuroplasticity, such as synaptic plasticity and neurogenesis, exists throughout the normal lifespan but declines with age is significantly impaired in individuals Alzheimer’s disease. Hence, promoting neuroplasticity may represent an effective strategy which disease can be alleviated. Due to their significant ability self-renew, differentiate, migrate, neural stem cells play essential role reversing neuronal damage, reducing pathology of disease, including amyloid-β, tau protein, neuroinflammation, secreting neurotrophic factors growth are related plasticity. These events promote neurogenesis repair microenvironment mammalian brain. Consequently, considered a potential regenerative therapy improve other neurodegenerative diseases. In this review, we discuss how regulate optimize effects enhance for treating clinic.
Язык: Английский
Процитировано
29