Frontiers in Psychiatry, Год журнала: 2025, Номер 16
Опубликована: Апрель 8, 2025
Язык: Английский
Frontiers in Neuroscience, Год журнала: 2025, Номер 19
Опубликована: Фев. 28, 2025
This review aimed to elucidate the mechanisms through which (i) physical activity (PA) enhances neuroplasticity and cognitive function in neurodegenerative disorders, (ii) identify specific PA interventions for improving rehabilitation programs. We conducted a literature search PubMed, Medline, Scopus, Web of Science, PsycINFO, covering publications from January 1990 August 2024. The strategy employed key terms related neuroplasticity, exercise, function, personalized activity. Inclusion criteria included original research on relationship between while exclusion eliminated studies focusing solely pharmacological interventions. identified multiple pathways may enhance including releasing neurotrophic factors, modulation neuroinflammation, reduction oxidative stress, enhancement synaptic connectivity neurogenesis. Aerobic exercise was found increase hippocampal volume by 1–2% improve executive scores 5–10% older adults. Resistance training enhanced control memory performance 12–18% elderly individuals. Mind–body exercises, such as yoga tai-chi, improved gray matter density memory-related brain regions 3–5% emotional regulation 15–20%. Dual-task attention processing speed 8–14% individuals with disorders. also discuss potential role AI-based AI preventing rehabilitating illnesses, highlighting innovative approaches patient outcomes. significantly disorders various mechanisms. resistance training, mind–body practices, dual-task exercises each offer unique benefits. Implementing these activities clinical settings can Future should focus creating tailored conditions, incorporating programs optimize rehabilitation.
Язык: Английский
Процитировано
4
Neurosciences, Год журнала: 2025, Номер 30(1), С. 5 - 19
Опубликована: Янв. 1, 2025
The hippocampus, noted as (HC), plays a crucial role in the processes of learning, memory formation, and spatial navigation. Recent research reveals that this brain region can undergo structural functional changes due to environmental exposures, including stress, noise pollution, sleep deprivation, microgravity. This review synthesizes findings from animal human studies, emphasizing HC's plasticity response these factors. It examines volume, architecture, neurogenesis, synaptic plasticity, gene expression highlights critical periods vulnerability influences impacting cognition behavior. also investigates underlying mechanisms such glucocorticoid signaling, epigenetic alterations, neural circuit adaptations. Understanding how HC reacts various exposures is vital for developing strategies enhance cognitive resilience mitigate negative effects on region. Further needed identify protective risk factors create effective interventions.
Язык: Английский
Процитировано
2
Cerebral Cortex, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Abstract Concurrent application of transcranial alternating current stimulation over distant cortical regions has been shown to modulate functional connectivity between stimulated regions; however, the precise mechanisms remain unclear. Here, we investigated how bifocal applied bilateral primary sensorimotor cortices modulates left and right motor (M1). Using a cross-over sham-controlled triple-blind design, 37 (27 female, age: 18 yrs) healthy participants received (1.0 mA, 20 Hz, min) cortices. Before after stimulation, M1s was assessed using imaginary coherence measured via resting-state electroencephalography interhemispheric inhibition dual-site magnetic protocol. Additionally, manual dexterity Purdue pegboard task. While remained unchanged beta (20 Hz) power decreased during session. Bifocal but not sham strengthened improved bimanual assembly performance. These results suggest that improvement in performance may be explained by modulation inhibition, rather than coupling oscillatory activity. As underlies many clinical symptoms neurological psychiatric disorders, these findings are invaluable developing noninvasive therapeutic interventions target neural networks alleviate symptoms.
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4271 - 4271
Опубликована: Апрель 30, 2025
The brain-derived neurotrophic factor (BDNF) has become one of the cornerstones neuropathology, influencing synaptic plasticity, cognitive resilience, and neuronal survival. Apart from its molecular biology, BDNF is a powerful target for transformative benefit in precision medicine, leading to innovative therapeutic approaches neurodegenerative psychiatric diseases like Alzheimer's disease (AD), Parkinson's (PD), major depressive disorder (MDD), post-traumatic stress (PTSD). Nevertheless, clinical applicability obstructed by hurdles delivery, patient-specific diversity, pleiotropic signaling. Here, we summarize findings research, including regulatory pathways diagnostic/prognostic biomarkers integrative approaches. We describe delivery systems, such as lipid nanoparticle-based mRNA therapies CRISPR-dCas9-based epigenetic editing that bypass obstacles BBB (blood-brain barrier) enzymatic degradation. recent implementation multiplex panels combining biodynamic indicators with tau amyloid-β signaling markers showcases novel levels specificity both early detection potential monitoring. Humanized preclinical models iPSC-derived neurons organoids point key role neurodeveloping processes, paralleling advances bridging observation environments. Moreover, tools delivering TrkB activators or AI-based dynamic care platforms enable tailored scalable treatments. This review also aims extend framework used understanding BDNF's relevance traditional situating more work detailing actions ischemic tissues gut-brain axis context systemic health. Finally, outline roadmap incorporation BDNF-centered into worldwide healthcare, highlighting ethical issues, equity, interdisciplinary decomposition. heralds new era neuroscience revolutionizing brain health paving way advancement medicine.
Язык: Английский
Процитировано
2
npj Mental Health Research, Год журнала: 2025, Номер 4(1)
Опубликована: Янв. 9, 2025
Attention-deficit/hyperactivity disorder (ADHD) presents with symptoms like impulsiveness, inattention, and hyperactivity, often affecting children's academic social functioning. Non-pharmacological interventions, such as digital cognitive therapy, are emerging complementary treatments for ADHD. The randomized controlled trial explored the impact of an AI-driven program on inattentiveness, neurophysiological markers in 41 children aged 8–12 Participants received either 12 weeks therapy or a placebo intervention. Assessments were conducted pre- post-intervention magnetoencephalography (MEG) analyzed brain activity. Results showed significant reductions impulsiveness inattentiveness scores treatment group, associated normalized MEG spectral profiles, indicating neuromaturation. Notably, improvements inhibitory control correlated profile normalization parieto-temporal cortex. Improvements control, linked to suggest can reduce ADHD by enhancing efficiency. This emphasizes personalized, technology-driven treatment, using assessing efficacy.
Язык: Английский
Процитировано
1
Brain Sciences, Год журнала: 2025, Номер 15(2), С. 110 - 110
Опубликована: Янв. 24, 2025
Background: The ionotropic glutamate receptor AMPA (AMPAR) mediates fast excitatory synaptic transmission and regulates strength in various parts of the CNS. Emotional challenges can affect these processes by influencing AMPAR levels localization via stress hormones, resulting, e.g., behavioral changes. AMPARs are essential for auditory processing, but their response to hormones central or peripheral system remains poorly understood. Therefore, this scoping review examines effects corticosterone (CORT), a primary hormone rodents, on rodent nervous considers potential implications system. Methods: We systematically searched PubMed, Web Science, OVID EMBASE using MeSH terms related receptors corticosterone. Studies were screened based predefined inclusion criteria, including original research published English that focused subunits (e.g., GluR1-4, GluA1-4, Gria1-4). Of 288 articles screened, 17 met criteria final analysis. Results: No reports found regarding CORT action Three main experimental models used included identified: neuronal cultures, isolated tissue animal models. Generally, short-term exposure increases surface mobility especially hippocampus prefrontal cortex. However, results from inconsistent due variations design other factors. study did not provide sufficient data clear conclusions. Conclusions: Variability limits our ability draw definitive conclusions about across different regions differences live studies highlight need standardized methods reporting. Since play crucial role CORT-induced changes cultures may occur Further is needed explore specific responses how influence disorders, which could help identify treatment strategies.
Язык: Английский
Процитировано
1
Neurobiology of Aging, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Nutrients, Год журнала: 2024, Номер 16(20), С. 3570 - 3570
Опубликована: Окт. 21, 2024
Recent research highlights the growing interest in impact of nutrition on cognitive health and function disease, as dietary habits are increasingly recognized crucial factors relation to brain function. This focus is especially important given rising prevalence neurodegenerative diseases decline associated with poor choices. Links now being sought between microbiota gut-brain axis. Mechanisms proposed that include low-grade chronic neuroinflammation, influence short-chain fatty acids, or disruption glial cells transmitters brain.
Язык: Английский
Процитировано
7
Neuroscience, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
7
The journal of nutrition health & aging, Год журнала: 2025, Номер 29(4), С. 100480 - 100480
Опубликована: Янв. 10, 2025
Язык: Английский
Процитировано
1