Cell Biochemistry and Function,
Год журнала:
2024,
Номер
43(1)
Опубликована: Дек. 31, 2024
Endometriosis
is
a
prevalent
chronic
gynaecological
disorder,
but
its
cause
still
unclear,
and
both
genetic
environmental
factors
may
contribute
disease
aetiology.
Prominent
amongst
the
latter
vitamin
D
which
can
be
obtained
either
by
action
of
sunlight
on
skin
or
from
dietary
sources.
Serum
levels
main
circulating
form
D,
25-hydroxvitamin
(25(OH)D),
have
been
reported
to
inversely
correlated
with
endometriosis,
suggesting
that
D-deficiency
risk
factor
for
disease.
Crucially,
active
1,25-dihydroxyvitamin
(1,25(OH)
The EPMA Journal,
Год журнала:
2024,
Номер
15(2), С. 163 - 205
Опубликована: Апрель 18, 2024
Despite
their
subordination
in
humans,
to
a
great
extent,
mitochondria
maintain
independent
status
but
tightly
cooperate
with
the
"host"
on
protecting
joint
life
quality
and
minimizing
health
risks.
Under
oxidative
stress
conditions,
healthy
promptly
increase
mitophagy
level
remove
damaged
"fellows"
rejuvenating
mitochondrial
population
sending
fragments
of
mtDNA
as
SOS
signals
all
systems
human
body.
As
long
metabolic
pathways
are
under
systemic
control
well-concerted
together,
adaptive
mechanisms
become
triggered
increasing
protection,
activating
antioxidant
defense
repair
machinery.
Contextually,
attributes
patho-/physiology
instrumental
for
predictive
medical
approach
cost-effective
treatments
tailored
individualized
patient
profiles
primary
(to
protect
vulnerable
individuals
again
health-to-disease
transition)
secondary
affected
disease
progression)
care.
Nutraceuticals
naturally
occurring
bioactive
compounds
demonstrating
health-promoting,
illness-preventing,
other
health-related
benefits.
Keeping
mind
health-promoting
properties
nutraceuticals
along
therapeutic
potential
safety
profile,
there
is
permanently
growing
demand
application
mitochondria-relevant
nutraceuticals.
Application
beneficial
only
if
meeting
needs
at
individual
level.
Therefore,
risk
assessment
creation
pivotal
importance
followed
by
adapted
nutraceutical
sets
needs.
Based
scientific
evidence
available
nutraceuticals,
this
article
presents
examples
frequent
which
require
protective
measures
targeted
holistic
following
advanced
concepts
predictive,
preventive,
personalized
medicine
(PPPM/3PM)
Aging
is
the
results
of
several
complex
and
multifactorial
processes,
where
agents
contribute
to
increase
intrinsic
vulnerability
susceptibility
age-related
diseases.
The
hallmarks
aging
are
a
set
biological
mechanisms,
finely
regulated
strictly
interconnected,
initiating
or
contributing
changes
anticipating
network
cellular
intercellular
connections
between
might
represent
possible
target
for
research
with
pleiotropic
affects.
Vitamin
D
(VitD)
known
have
positive
impact
not
only
on
muscle
bone
health,
but
also
extra-skeletal
districts,
due
widespread
presence
VDRs
(VDR).
VitD
VDR
could
be
molecules
potentially
targeting
hallmark
network.
To
date,
evidence
about
potential
effect
scarce
in
humans
mainly
based
preclinical
models.
Although
underpowered
heterogeneous,
in-human
studies
seems
confirm
modulatory
some
However,
more
investigations
needed
clarify
effects
its
aging,
hopefully
highlighting
courses
translational
applications
clinical
conclusions.
Nutrients,
Год журнала:
2024,
Номер
16(6), С. 906 - 906
Опубликована: Март 21, 2024
Aging
is
the
result
of
several
complex
and
multifactorial
processes,
where
agents
contribute
to
an
increased
intrinsic
vulnerability
susceptibility
age-related
diseases.
The
hallmarks
aging
are
a
set
biological
mechanisms
that
finely
regulated
strictly
interconnected,
initiating
or
contributing
changes
anticipating
network
cellular
intercellular
connections
between
might
represent
possible
target
for
research
with
pleiotropic
effects.
Vitamin
D
(VitD)
known
have
positive
impact
not
only
on
muscle
bone
health
but
also
extra-skeletal
districts,
due
widespread
presence
Receptors
(VDRs).
VitD
VDR
could
be
molecules
potentially
targeting
network.
To
date,
evidence
about
potential
effects
scarce
in
humans
mainly
based
preclinical
models.
Although
underpowered
heterogeneous,
in-human
studies
seem
confirm
modulatory
effect
some
However,
more
investigations
needed
clarify
its
hallmark
aging,
hopefully
highlighting
courses
translational
applications
clinical
conclusions.
KIDNEYS,
Год журнала:
2025,
Номер
13(4), С. 257 - 260
Опубликована: Янв. 9, 2025
The
analysis
of
literature
revealed
the
peculiarities
vitamin
D
metabolism
in
diabetic
kidney
damage,
as
well
its
role
development
renal,
metabolic
changes,
including
bone
and
mineral
disorders.
Vitamin
D,
due
to
influence
on
various
physiological
processes
through
receptors,
plays
a
key
regulation
metabolism,
functioning
immune
system
control
other
extraskeletal
effects.
In
patients
with
deficiency
causes
impaired
hydroxylation
formation
an
active
metabolite
(1,25(OH)2D3),
which
leads
progression
proteinuria
fibrosis.
mechanisms
glucose
interaction
at
level
proximal
tubules
were
analyzed,
emphasizes
need
for
further
research
develop
therapeutic
strategies
correcting
damage
order
improve
their
prognosis.
Nutrients,
Год журнала:
2024,
Номер
17(1), С. 115 - 115
Опубликована: Дек. 30, 2024
Vitamin
D
is
increasingly
recognized
for
its
role
in
cardiovascular
health
beyond
well-established
effects
on
bone
metabolism.
This
review
synthesizes
findings
from
observational
studies,
interventional
trials,
and
meta-analyses
to
clarify
the
mechanisms
through
which
vitamin
impacts
health,
including
influence
vascular
function,
inflammation,
metabolic
pathways.
Additionally,
this
emphasizes
importance
of
a
personalized
approach
supplementation,
integrating
individual
risk
profiles,
baseline
levels,
comorbid
conditions,
such
as
hypertension
diabetes.
While
current
evidence
supports
association
between
low
levels
increased
mortality,
work
contributes
novel
insights
by
proposing
tailored
strategies
particularly
high-risk
subgroups.
Practical
recommendations
implementing
these
clinical
practice
are
also
discussed,
providing
framework
optimizing
outcomes
individualized
management.
Over
the
last
decades,
in
addition
to
improvement
of
pathophysiological
knowledge
regarding
role
and
mechanisms
action
Vitamin
D,
there
has
been
a
progressive
advancement
analytical
technologies
for
its
determination,
as
well
methodological
standardization.
A
significant
number
scientific
works,
meta-analyses,
guidelines
have
published
on
importance
D
need
supplementation
deficient
individuals.
However,
it
appears
necessary
clarify
fundamental
elements
related
determination
(both
at
strictly
post-analytical
levels)
evidence
efficacy/safety
supplementation.
Additionally,
given
important
interrelations
between
parathyroid
hormone
(PTH),
fibroblast
growth
factor-23
(FGF23),
issues
clinical
utility
these
biomarkers
will
be
discussed.
Over
the
last
decades,
in
addition
to
improvement
of
pathophysiological
knowledge
regarding
role
and
mechanisms
action
vitamin
D,
there
has
been
a
progressive
advancement
analytical
technologies
for
its
measurement,
as
well
methodological
standardization.
A
significant
number
scientific
works,
meta-analyses,
guidelines
have
published
on
importance
D
need
supplementation
deficient
individuals.
However,
it
appears
necessary
clarify
fundamental
elements
related
measurement
(both
at
strictly
post-analytical
levels)
evidence
efficacy/safety
supplementation.
In
particular,
is
discuss
current
recommended
levels
deficiency,
insufficiency
possible
toxicity
light
from
standardization
projects.
Additionally,
given
important
interrelations
between
parathyroid
hormone
(PTH),
fibroblast
growth
factor-23
(FGF23),
issues
clinical
utility
these
biomarkers
will
be
discussed.
Respiratory Research,
Год журнала:
2024,
Номер
25(1)
Опубликована: Март 8, 2024
Vitamin
D
may
help
to
alleviate
asthma
exacerbation
because
of
its
anti-inflammation
effect,
but
the
evidence
is
inconsistent
in
childhood
asthma.
MiRNAs
are
important
mediators
pathogenesis
and
also
excellent
non-invasive
biomarkers.
We
hypothesized
that
circulating
miRNAs
associated
with
modified
by
vitamin
levels.
sequenced
baseline
serum
from
461
participants
Childhood
Asthma
Management
Program
(CAMP).
Logistic
regression
was
used
associate
miRNA
expression
through
interaction
analysis
first
then
stratified
insufficient
sufficient
groups.
Microarray
lymphoblastoid
B-cells
(LCLs)
treated
or
sham
43
subjects
CAMP
were
for
validation
vitro.
The
function
gene
modules
weighted
co-expression
network
(WGCNA).
identified
eleven
effect
modification.
Of
which,
five
significant
group
nine
group.
Six
miRNAs,
including
hsa-miR-143-3p,
hsa-miR-192-5p,
hsa-miR-151a-5p,
hsa-miR-24-3p,
hsa-miR-22-3p
hsa-miR-451a
significantly
immune-related
functions,
implying
mediate
on
immune
pathways.
In
addition,
hsa-miR-143-3p
potential
predictors
at
different
their
effects
directly
impacted
Metabolites,
Год журнала:
2024,
Номер
14(10), С. 558 - 558
Опубликована: Окт. 17, 2024
Porcine
models
are
increasingly
recognized
for
their
similarities
to
humans
and
have
been
utilized
in
disease
modeling
organ
grafting
research.
While
extensive
metabolomics
studies
conducted
swine,
primarily
focusing
on
conventional
cohorts
or
specific
animal
models,
the
composition
functions
of
fecal
metabolites
pigs
across
different
age
groups-particularly
elderly-remain
inadequately
understood.
In
this
study,
an
untargeted
approach
was
employed
analyze
metabolomes
at
three
distinct
stages:
young
(one
year),
middle-aged
(four
years),
elderly
(eight
years).
The
objective
elucidate
age-associated
changes
metabolite
functionality
under
standardized
rearing
conditions.
metabolomic
analysis
revealed
a
diverse
array
age-related
metabolites.
Notably,
L-methionine
sulfoxide
levels
were
found
increase
with
age,
whereas
cytidine-5-monophosphate
exhibited
gradual
decline
throughout
aging
process.
These
demonstrated
alterations
various
biological
pathways,
including
energy
metabolism,
pyrimidine
lipid
amino
acid
metabolism.
Collectively,
identified
key
metabolites,
such
as
Cholecalciferol,
may
serve
potential
biomarkers
senescence,
providing
valuable
insights
into
mechanistic
understanding
pigs.
