Current and Potential Use of Biologically Active Compounds Derived from Cannabis sativa L. in the Treatment of Selected Diseases
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12738 - 12738
Опубликована: Ноя. 27, 2024
Cannabis
sativa
L.
contains
numerous
compounds
with
antioxidant
and
anti-inflammatory
properties,
including
the
flavonoids
cannabinoids,
particularly
Δ-9-tetrahydrocannabinol
(THC)
cannabidiol
(CBD).
Cannabinoids
have
an
effect
on
endocannabinoid
system
(ECS),
a
cellular
communication
network,
are,
hence,
widely
studied
for
medical
applications.
Epidiolex®,
99%
pure
oral
CBD
extract,
has
been
approved
by
FDA
treatment
of
epilepsy.
Nabiximols
(Sativex)
is
oromucosal
spray
containing
equal
volume
THC
CBD,
it
commonly
used
as
add-on
unresponsive
spasticity
in
multiple
sclerosis
(MS)
patients.
Several
vitro
vivo
studies
also
shown
that
cannabinoids
can
be
to
treat
various
types
cancer,
such
melanoma
brain
glioblastoma;
first
positive
clinical
trials
anticancer
THC:CBD
blend
temozolomide
(TMZ)
highly
invasive
cancer
are
very
promising.
The
exert
their
properties
investigations
induction
cell
death,
mainly
apoptosis
cytotoxic
autophagy,
inhibition
proliferation.
In
several
studies,
found
induce
tumor
regression
inhibit
angiogenic
mechanisms
vivo,
well
two
low-numbered
epidemiological
studies.
They
exhibit
antiviral
effects
inhibiting
ACE2
transcription,
blocking
viral
replication
fusion,
acting
agents;
indeed,
prior
consumption
(a
study
93,565
persons
Chicago)
associated
much
lower
incidence
SARS-CoV-2
infections.
It
postulated
cannabis
extracts
many
other
diseases
systemic
lupus
erythematosus,
type
1
diabetes,
or
neurological
disorders,
e.g.,
Alzheimer’s
disease.
aim
this
review
outline
current
state
knowledge
regarding
currently
medicinal
preparations
derived
from
C.
selected
diseases,
present
latest
research
potential
applications
its
secondary
metabolites.
Язык: Английский
Repurposing Drugs: A Promising Therapeutic Approach against Alzheimer’s Disease
Ageing Research Reviews,
Год журнала:
2025,
Номер
unknown, С. 102698 - 102698
Опубликована: Фев. 1, 2025
Язык: Английский
Modulation of Δ5- and Δ6-desaturases in the brain-liver axis
Nutrition,
Год журнала:
2024,
Номер
131, С. 112629 - 112629
Опубликована: Ноя. 12, 2024
Язык: Английский
Prospects in the Use of Cannabis sativa Extracts in Nanoemulsions
BioTech,
Год журнала:
2024,
Номер
13(4), С. 53 - 53
Опубликована: Дек. 2, 2024
Cannabis
sativa
plants
have
been
widely
investigated
for
their
specific
compounds
with
medicinal
properties.
These
bioactive
exert
preventive
and
curative
effects
on
non-communicable
infectious
diseases.
However,
C.
extracts
barely
investigated,
although
they
constitute
an
affordable
option
to
treat
human
Nonetheless,
antioxidant,
antimicrobial,
immunogenicity
associated
extracts.
Furthermore,
innovative
extraction
methods
in
combination
nanoformulations
proposed
increase
desirable
compounds’
availability,
distribution,
conservation,
which
can
be
aided
by
modern
computational
tools
a
transdisciplinary
approach.
This
review
aims
describe
available
nanoformulation
sativa,
as
well
its
known
immunogenic
activities.
Critical
points
the
use
of
are
identified
some
prospects
envisaged.
Язык: Английский