Recent progress of metal–organic frameworks as sensors in (bio)analytical fields: towards real-world applications

Analytical and Bioanalytical Chemistry, Год журнала: 2023, Номер 415(11), С. 2005 - 2023

Опубликована: Янв. 4, 2023

Abstract The deployment of metal–organic frameworks (MOFs) in a plethora analytical and bioanalytical applications is growing research area. Their unique properties such as high but tunable porosity, well-defined channels or pores, ease post-synthetic modification to incorporate additional functional units make them ideal candidates for sensing applications. This possible because the interaction analytes with MOF often results change its structure, eventually leading intrinsic physicochemical which then transduced into measurable signal. porosity allows adsorption very efficiently, while pore sizes/nature and/or installation specific recognition groups allow modulating affinity towards different classes compounds, turn lead good sensor sensitivity selectivity, respectively. Some figures are given illustrate potential MOF-based sensors most relevant application fields, future challenges opportunities their translation from academia (i.e., laboratory testing properties) industry real-world devices) critically discussed. Graphical abstract

Язык: Английский

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Electrochemical immunosensors using electrodeposited gold nanostructures for detecting the S proteins from SARS-CoV and SARS-CoV-2

Analytical and Bioanalytical Chemistry, Год журнала: 2022, Номер 414(18), С. 5507 - 5517

Опубликована: Фев. 15, 2022

Язык: Английский

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Sandwich-type electrochemical aptasensor based on Au-modified conductive octahedral carbon architecture and snowflake-like PtCuNi for the sensitive detection of cardiac troponin I

Biosensors and Bioelectronics, Год журнала: 2022, Номер 212, С. 114431 - 114431

Опубликована: Май 28, 2022

Язык: Английский

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Metal–organic framework detectives meet infectious pathogens: A powerful tool against pandemics

Coordination Chemistry Reviews, Год журнала: 2023, Номер 488, С. 215160 - 215160

Опубликована: Май 2, 2023

Язык: Английский

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Functional Nanomaterials Enhancing Electrochemical Biosensors as Smart Tools for Detecting Infectious Viral Diseases

Molecules, Год журнала: 2023, Номер 28(9), С. 3777 - 3777

Опубликована: Апрель 27, 2023

Electrochemical biosensors are known as analytical tools, guaranteeing rapid and on-site results in medical diagnostics, food safety, environmental protection, life sciences research. Current research focuses on developing sensors for specific targets addresses challenges to be solved before their commercialization. These typically include the lowering of limit detection, widening linear concentration range, analysis real samples a environment comparison with standard validation method. Nowadays, functional nanomaterials designed applied electrochemical biosensing support all these challenges. This review will address integration development diagnosis viral infections, such COVID-19, middle east respiratory syndrome (MERS), influenza, hepatitis, human immunodeficiency virus (HIV), dengue, among others. The role relevance nanomaterial, type biosensor, technique adopted discussed. Finally, critical issues applying laboratory samples, future perspectives, commercialization aspects detection analyzed.

Язык: Английский

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Electrochemical lateral-flow device for rapid COVID-19 antigen-diagnostic testing

Bioelectrochemistry, Год журнала: 2023, Номер 152, С. 108438 - 108438

Опубликована: Апрель 6, 2023

Язык: Английский

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Sensitive SERS detection of SARS-CoV‑2 spike protein based on Y‑shaped-aptasensor and AuNPs/COFs composites

Sensors and Actuators B Chemical, Год журнала: 2023, Номер 394, С. 134470 - 134470

Опубликована: Авг. 15, 2023

Язык: Английский

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Rapid assays of SARS-CoV-2 virus and noble biosensors by nanomaterials

Nano Convergence, Год журнала: 2024, Номер 11(1)

Опубликована: Янв. 8, 2024

Abstract The COVID-19 outbreak caused by SARS-CoV-2 in late 2019 has spread rapidly across the world to form a global epidemic of respiratory infectious diseases. Increased investigations on diagnostic tools are currently implemented assist rapid identification virus because mass and diagnosis might be best way prevent virus. This critical review discusses detection principles, fabrication techniques, applications with three categories: nuclear acid augmentation test, immunoassay test biosensors. Special efforts were put enhancement nanomaterials biosensors for rapid, sensitive, low-cost diagnostics Future developments suggested regarding potential candidates hospitals, clinics laboratories control prevention large-scale epidemic. Graphical

Язык: Английский

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Recent advances in metal–organic frameworks as emerging platforms for immunoassays

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 171, С. 117520 - 117520

Опубликована: Янв. 4, 2024

Язык: Английский

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Electrospun Poly-ε-caprolactone/Poly-l-lysine (PCL/PLL) Nanofibers as an Emergent Material for the Preparation of Electrochemical Immunosensor to Detect Serum Amyloid A

ACS Applied Polymer Materials, Год журнала: 2024, Номер 6(7), С. 3778 - 3786

Опубликована: Март 20, 2024

Serum amyloid (SAA), one of the acute-phase reactants, plays a significant role in acute and chronic inflammatory diseases. It is widely used clinical field as biomarker inflammation. Developing rapid sensitive measurement systems crucial to precisely detect presence SAA, even at very low levels. Therefore, this study, we developed an electrochemical immunosensor using electrospun nanofibers (ESNFs) based on poly-ε-caprolactone (PCL) poly-l-Lysine (PLL) immobilization matrix. ESNFs covered surfaces screen-printed carbon electrodes (SPCEs) for enhanced performance. The PCL/PLL were characterized water contact angle measurements, scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET) method, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) techniques. Cyclic voltammetry (CV), differential pulse (DPV), impedance (EIS) employed characterize behavior electrode surface. In conjunction with analytical characterizations proposed immunosensor, linear range, limit detection (LOD), interfering effect some potential chemicals, real sample applications carried out. sensor exhibited working range 0.1–50 0.1–10 ng/mL calculated LOD 0.061 respectively. Additionally, demonstrated advanced specificity, showing no response species such urea, glucose, insulin, C-reactive protein. Validation yielded excellent recovery artificial serum (100.04%), human (103.32%), saliva (99.5%) samples containing 1 SAA. believe that sensor, its high sensitivity, can effectively contribute SAA levels biological fluids during tests.

Язык: Английский

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