ACS Applied Nano Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 27, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2360 - 2360
Опубликована: Фев. 17, 2024
This review explores the diverse applications of gold nanoparticles (AuNPs) in neurological diseases, with a specific focus on Alzheimer's disease (AD), Parkinson's (PD), and stroke. The introduction highlights pivotal role neuroinflammation these disorders introduces unique properties AuNPs. review's core examines mechanisms by which AuNPs exert neuroprotection anti-neuro-inflammatory effects, elucidating various pathways through they manifest properties. potential therapeutic AD are discussed, shedding light promising avenues for therapy. also prospects utilizing PD interventions, presenting hopeful outlook future treatments. Additionally, delves into providing after strokes, emphasizing their significance mitigating cerebrovascular accidents' aftermath. Experimental findings from cellular animal models consolidated to provide comprehensive overview AuNPs' effectiveness, offering insights impact at both vivo levels. enhances our understanding diseases lays groundwork innovative strategies neurology.
Язык: Английский
Процитировано
29
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160631 - 160631
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
Abstract Neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease, present formidable challenges in modern medicine due to their complex pathologies the absence of curative treatments. Despite advances symptomatic management, early diagnosis remains essential for mitigating progression improving patient outcomes. Traditional diagnostic methods, such as MRI, PET, cerebrospinal fluid biomarker analysis, are often inadequate detection these diseases. Emerging porous materials, including metal–organic frameworks (MOFs), covalent–organic (COFs), MXene, zeolites, silicon, offer promising new approaches neurodegenerative These characterized by highly tunable physicochemical properties, have potential capture concentrate disease‐specific biomarkers amyloid‐beta (Aβ), tau protein, alpha‐synuclein (α‐Syn). The integration materials into advanced biosensors real‐time holds promise revolutionizing neurodiagnostic, enabling non‐invasive, sensitive, specific platforms. Furthermore, incorporation artificial intelligence (AI) machine learning (ML) techniques analysis sensor data enhances accuracy allows more efficient interpretation profiles. AI ML can optimize feature selection, improve pattern recognition, facilitate prediction progression, making them indispensable tools personalized medicine. This review explores diagnostics, emphasizing design, functionality, synergistic role advancing clinical applications.
Язык: Английский
Процитировано
2
Talanta, Год журнала: 2025, Номер 286, С. 127522 - 127522
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
1
Materials Horizons, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder marked by permanent impairment of brain function across the whole brain. This condition results in deterioration cognitive patients and frequently associated with psychological symptoms such as agitation anxiety, imposing significant burden on both their families. Nanomaterials possess numerous distinctive physical chemical features that render them extensively utilized. In biomedical domain, nanomaterials can be utilized for prevention therapy, including medication delivery systems, biosensors, tissue engineering. article explores etiology potential molecular processes AD, well application carbon-based diagnosis treatment AD. Some are carbon quantum dots, nanotubes, graphene, among others. These materials physicochemical highly promising applications biosensing, drug delivery, neuroprotection, photothermal treatment. addition, this review explored various therapeutic approaches AD terms reducing inflammation, preventing oxidative damage, inhibiting Aβ aggregation. The advent nanotechnology has facilitated development novel disease. strategies provide early diagnosis, effective intervention neuroprotection
Язык: Английский
Процитировано
4
Biosensors and Bioelectronics, Год журнала: 2025, Номер 284, С. 117535 - 117535
Опубликована: Май 2, 2025
Язык: Английский
Процитировано
0
Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 39
Опубликована: Май 21, 2025
Neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS), and prion diseases, pose a significant escalating health challenge in the context of an aging population. Gold nanoparticles (GNPs) have emerged as promising agents diagnostic therapeutic realms NDDs, due to their unique ability enhance drug delivery across blood-brain barrier (BBB). This paper presents comprehensive review application GNPs NDDs diagnosis therapy, highlighting potential transform patient management. Additionally, we systematically address critical challenges associated with use treatment focusing on pharmacokinetics metabolism, toxicity, long-term biocompatibility, regulatory challenges, cost-effectiveness. Furthermore, synthesize ongoing clinical studies provide holistic perspective current state research this field. We also explore prospective trajectories translational GNPs, which may usher new era NDDs.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156888 - 156888
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
2
Discover Nano, Год журнала: 2024, Номер 19(1)
Опубликована: Сен. 17, 2024
With the size of aging population increasing worldwide, effective diagnosis and treatment neurodegenerative diseases (NDDs) has become more important. Two-dimensional (2D) materials offer specific advantages for NDDs due to their high sensitivity, selectivity, stability, biocompatibility, as well excellent physical chemical characteristics. As such, 2D a promising avenue development highly sensitive, selective, biocompatible theragnostics. This review provides an interdisciplinary overview advanced use in biosensors, drug delivery, tissue engineering/regenerative medicine and/or NDDs. The material-based biosensors enabled early detection monitoring via precise biomarkers or biological changes, while delivery systems targeted controlled release therapeutics brain, crossing blood-brain barrier enhancing effectiveness. In addition, when used engineering regenerative medicine, facilitate cell growth, differentiation, regeneration restore neuronal functions repair damaged neural networks. Overall, show great promise NDDs, thus improving quality life patients population.
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 27, 2024
Язык: Английский
Процитировано
0