Electrochemical protein biosensors for disease marker detection: progress and opportunities

Microsystems & Nanoengineering, Год журнала: 2024, Номер 10(1)

Опубликована: Май 22, 2024

Abstract The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology. Proteins are extensively used as biological macromolecular markers in disease diagnosis the analysis therapeutic effects. Electrochemical protein biosensors have achieved desirable specificity by using specific antibody–antigen binding principle immunology. However, active centers biomarkers surrounded a peptide matrix, which hinders charge transfer results insufficient sensor sensitivity. Therefore, electrode-modified materials transducer devices been designed to increase sensitivity improve practical application prospects electrochemical sensors. In this review, we summarize recent reports biomarker detection. We highlight latest research on detection cancer, viral infectious diseases, inflammation, other diseases. corresponding sensitive materials, structures, principles associated with such also addressed generally. Finally, present an outlook use marker next few years.

Язык: Английский

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Magnetic molecularly imprinted polymers and carbon dots molecularly imprinted polymers for green micro-extraction and analysis of pharmaceuticals in a variety of matrices

Microchemical Journal, Год журнала: 2024, Номер 205, С. 111235 - 111235

Опубликована: Июль 18, 2024

Язык: Английский

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Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread another part body. It deadliest disease in world; therefore, rapid and sensitive detection essential fight it. In past few decades, many diagnosis tools have been developed detect cancer monitor therapy progress. Among them, electrochemical biosensor showed promising significance due its capability early detection, selectivity, sensitivity, flexibility, portability cost‐effectiveness. The performance sensor depends on surface engineering as well development techniques based types biomarkers. This review covers importance diagnosis, basic concept biosensor, design strategy biosensors including state‐of‐the‐art for different biomarker detection. Additionally, limitations advantages were parallelly explained. Finally, future direction advancement comprehensively discussed. author trusts that insights thus explained will lead further research scholarly community aimed at expanding theoretical knowledge pragmatic innovation sensing devices Such findings are anticipated facilitate high‐end developments both area application.

Язык: Английский

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Beyond Single-Analyte Detection: Advancing Molecularly Imprinted Polymers for Simultaneous Multi-Target Sensing

TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер 185, С. 118177 - 118177

Опубликована: Фев. 6, 2025

Язык: Английский

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Thermal sensing of syringic acid in food samples via molecularly imprinted polymers synthesized from bio-based deep eutectic solvents as monomers

Food Chemistry, Год журнала: 2025, Номер unknown, С. 143947 - 143947

Опубликована: Март 1, 2025

Язык: Английский

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Disease diagnosis and application analysis of molecularly imprinted polymers (MIPs) in saliva detection

Talanta, Год журнала: 2023, Номер 269, С. 125394 - 125394

Опубликована: Ноя. 6, 2023

Язык: Английский

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Advancements and potentials of molecularly imprinted polymer-based sensors for lysozyme determination in food and clinical samples

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 155828 - 155828

Опубликована: Сен. 1, 2024

Язык: Английский

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pH-Sensitive Nanoparticles of Epigallocatechin-3-Gallate in Enhanced Colorectal Cancer Therapy

Nanomedicine, Год журнала: 2024, Номер 19(6), С. 459 - 481

Опубликована: Янв. 15, 2024

Aim: Encapsulating epigallocatechin-3-gallate (EGCG) in pH-sensitive polymeric nanoparticles for targeted delivery of drugs could revolutionize colorectal cancer treatment. Materials & methods: Nanoparticles were synthesized to release at colon pH. Dynamic light scattering measured their average diameter and ζ-potential, while differential scanning calorimetry x-ray diffraction assessed EGCG encapsulation. Results: The showed stability bioavailability the gastrointestinal tract, efficiently encapsulating releasing over 93% pH 7.2. They enhanced cytotoxicity against HT-29 cells demonstrated antibacterial properties, increasing apoptosis cell cycle arrest. Conclusion: study underscores potential enhancing therapy, aiming minimize side effects improve therapeutic outcomes.

Язык: Английский

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Efficiency of electrochemical immuno- vs. apta(geno)sensors for multiple cancer biomarkers detection

Talanta, Год журнала: 2024, Номер 281, С. 126870 - 126870

Опубликована: Сен. 17, 2024

Язык: Английский

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Current Status and Future Prospects of Lyotropic Liquid Crystals as a Nanocarrier Delivery System for the Treatment of Cancer

AAPS PharmSciTech, Год журнала: 2025, Номер 26(2)

Опубликована: Фев. 7, 2025

Язык: Английский

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