Electrochemical protein biosensors for disease marker detection: progress and opportunities

Microsystems & Nanoengineering, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 22, 2024

Abstract The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology. Proteins are extensively used as biological macromolecular markers in disease diagnosis the analysis therapeutic effects. Electrochemical protein biosensors have achieved desirable specificity by using specific antibody–antigen binding principle immunology. However, active centers biomarkers surrounded a peptide matrix, which hinders charge transfer results insufficient sensor sensitivity. Therefore, electrode-modified materials transducer devices been designed to increase sensitivity improve practical application prospects electrochemical sensors. In this review, we summarize recent reports biomarker detection. We highlight latest research on detection cancer, viral infectious diseases, inflammation, other diseases. corresponding sensitive materials, structures, principles associated with such also addressed generally. Finally, present an outlook use marker next few years.

Language: Английский

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Magnetic molecularly imprinted polymers and carbon dots molecularly imprinted polymers for green micro-extraction and analysis of pharmaceuticals in a variety of matrices

Microchemical Journal, Journal Year: 2024, Volume and Issue: 205, P. 111235 - 111235

Published: July 18, 2024

Language: Английский

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Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread another part body. It deadliest disease in world; therefore, rapid and sensitive detection essential fight it. In past few decades, many diagnosis tools have been developed detect cancer monitor therapy progress. Among them, electrochemical biosensor showed promising significance due its capability early detection, selectivity, sensitivity, flexibility, portability cost‐effectiveness. The performance sensor depends on surface engineering as well development techniques based types biomarkers. This review covers importance diagnosis, basic concept biosensor, design strategy biosensors including state‐of‐the‐art for different biomarker detection. Additionally, limitations advantages were parallelly explained. Finally, future direction advancement comprehensively discussed. author trusts that insights thus explained will lead further research scholarly community aimed at expanding theoretical knowledge pragmatic innovation sensing devices Such findings are anticipated facilitate high‐end developments both area application.

Language: Английский

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Beyond Single-Analyte Detection: Advancing Molecularly Imprinted Polymers for Simultaneous Multi-Target Sensing

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: 185, P. 118177 - 118177

Published: Feb. 6, 2025

Language: Английский

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Disease diagnosis and application analysis of molecularly imprinted polymers (MIPs) in saliva detection

Talanta, Journal Year: 2023, Volume and Issue: 269, P. 125394 - 125394

Published: Nov. 6, 2023

Language: Английский

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Advancements and potentials of molecularly imprinted polymer-based sensors for lysozyme determination in food and clinical samples

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 155828 - 155828

Published: Sept. 1, 2024

Language: Английский

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pH-Sensitive Nanoparticles of Epigallocatechin-3-Gallate in Enhanced Colorectal Cancer Therapy

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(6), P. 459 - 481

Published: Jan. 15, 2024

Aim: Encapsulating epigallocatechin-3-gallate (EGCG) in pH-sensitive polymeric nanoparticles for targeted delivery of drugs could revolutionize colorectal cancer treatment. Materials & methods: Nanoparticles were synthesized to release at colon pH. Dynamic light scattering measured their average diameter and ζ-potential, while differential scanning calorimetry x-ray diffraction assessed EGCG encapsulation. Results: The showed stability bioavailability the gastrointestinal tract, efficiently encapsulating releasing over 93% pH 7.2. They enhanced cytotoxicity against HT-29 cells demonstrated antibacterial properties, increasing apoptosis cell cycle arrest. Conclusion: study underscores potential enhancing therapy, aiming minimize side effects improve therapeutic outcomes.

Language: Английский

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Efficiency of electrochemical immuno- vs. apta(geno)sensors for multiple cancer biomarkers detection

Talanta, Journal Year: 2024, Volume and Issue: 281, P. 126870 - 126870

Published: Sept. 17, 2024

Language: Английский

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Current Status and Future Prospects of Lyotropic Liquid Crystals as a Nanocarrier Delivery System for the Treatment of Cancer

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 7, 2025

Language: Английский

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MIP@spots: Novel Fluorescent Sensors for CA 19-9 Detection on Solid Substrates

Published: Jan. 1, 2025

Language: Английский

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