Recent Advances in Gold Nanocluster-Based Biosensing and Therapy: A Review

Molecules, Год журнала: 2024, Номер 29(7), С. 1574 - 1574

Опубликована: Апрель 1, 2024

Gold nanoclusters (Au NCs) with bright emission and unique chemical reactivity characters have been widely applied for optical sensing imaging. With a combination of surface modifications, effective therapeutic treatments tumors are realized. In this review, we summarize the recently adopted biosensing therapy events based on Au NCs. Homogeneous fluorometric systems toward various targets, including ions, small molecules, reactive oxygen species, biomacromolecules, cancer cells, bacteria, in vitro vivo, presented by turn-off, turn-on, ratiometric tactics. The applications concluded three aspects: photodynamic therapy, photothermal as drug carrier. basic mechanisms performances these introduced. Finally, review highlights challenges future trend NC-based systems.

Язык: Английский

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Fluorescent nanosensors for detection of microbial toxins in food matrices: a review

Journal of Food Measurement & Characterization, Год журнала: 2024, Номер 18(9), С. 7669 - 7699

Опубликована: Июль 27, 2024

Язык: Английский

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Synthesis of blue emitting Aloe-Gold nanoclusters and their molecular Binding, antibacterial and cytotoxicity Profiling

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 113903 - 113903

Опубликована: Янв. 1, 2025

Язык: Английский

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MoS2–Plasmonic Hybrid Platforms: Next-Generation Tools for Biological Applications

Nanomaterials, Год журнала: 2025, Номер 15(2), С. 111 - 111

Опубликована: Янв. 13, 2025

The combination of molybdenum disulfide (MoS2) with plasmonic nanomaterials has opened up new possibilities in biological applications by combining MoS2’s biocompatibility and high surface area the optical sensitivity metals. These MoS2–plasmonic hybrid systems hold great promise areas such as biosensing, bioimaging, phototherapy, where their complementary properties facilitate improved detection, real-time visualization, targeted therapeutic interventions. adjustable features, combined plasmon resonance noble metals gold silver, enhance signal amplification, enabling detailed imaging selective photothermal or photodynamic therapies while minimizing effects on healthy tissue. This review explores various synthesis strategies for hybrids, including seed-mediated growth, situ deposition, heterojunction formation, which enable tailored configurations optimized specific applications. primary focus include highly sensitive biosensors detecting cancer infectious disease biomarkers, high-resolution cellular dynamics, development phototherapy methods that allow accurate tumor ablation through light-induced thermal reactive oxygen species generation. Despite promising advancements translating these platforms into clinical practice requires overcoming considerable challenges, reproducibility, toxicity, stability physiological conditions, delivery, scalable manufacturing. Addressing challenges is essential realizing potential next-generation tools diagnostics therapies.

Язык: Английский

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Development of novel FRET aptasensor based on the quenching ability of iron oxide-gold nanostars for the detection of aflatoxin M1

Food Chemistry, Год журнала: 2024, Номер unknown, С. 141575 - 141575

Опубликована: Окт. 1, 2024

Язык: Английский

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A highly sensitive and reusable magnetic nano-electrochemical biosensor for the detection of the liver cancer biomarker heat shock protein 70

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159860 - 159860

Опубликована: Янв. 1, 2025

Язык: Английский

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Synthesis of polyadenine-aptamer-stabilized gold nanoclusters and application to the detection of tobramycin in real samples based on their peroxidase-like activity

Food Chemistry, Год журнала: 2025, Номер 474, С. 143194 - 143194

Опубликована: Фев. 3, 2025

Язык: Английский

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Au@Fe₃O₄ Nanoparticle-Based Colorimetric Aptasensor for Noninvasive Screening of Colorectal Cancer via Detection of Parvimonas micra

ACS Sensors, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Colorectal cancer (CRC) is a common malignancy requiring early screening to improve patient outcomes. Current methods such as colonoscopy and fecal occult blood tests have several limitations including high cost, poor specificity, invasiveness, inconvenience. Recent research has identified specific bacterial communities associated with CRC, notably Parvimonas micra (P. micra), which serves biomarker for diagnosis owing its accumulation in the malignant tissues feces of CRC patients. Herein, we employed whole-bacterium systematic evolution ligands by exponential enrichment (SELEX) method isolate high-affinity aptamers against P. using 17 selection cycles. These were subsequently bound Au@Fe3O4 nanoparticles, interaction inhibited peroxidase-like activity thereby blocking 3,3',5,5'-tetramethylbenzidine (TMB) chromogenic reaction resulting measurable reduction absorbance. This colorimetric detection strategy demonstrated linear response across range 100-108 CFU/mL limit 11 CFU/mL. Using aptasensor, assessed abundance clinical samples found significantly higher levels patients compared that healthy individuals, was consistent quantitative polymerase chain results. study therefore represents first successful identification an aptamer affinity specificity micra, leading development highly sensitive aptasensor detection. The presented approach significant potential diagnosis.

Язык: Английский

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Emerging applications of biorecognition elements-based optical biosensors for food safety monitoring

Опубликована: Фев. 14, 2025

Язык: Английский

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Target-Triggered Aptasensor Using Dual-Colored Dye-Doped Silica Nanoparticles for Simultaneous Detection of Ampicillin and Oxytetracycline

Talanta, Год журнала: 2025, Номер 291, С. 127908 - 127908

Опубликована: Март 7, 2025

Язык: Английский

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