Recent Advances in Gold Nanocluster-Based Biosensing and Therapy: A Review

Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1574 - 1574

Published: April 1, 2024

Gold nanoclusters (Au NCs) with bright emission and unique chemical reactivity characters have been widely applied for optical sensing imaging. With a combination of surface modifications, effective therapeutic treatments tumors are realized. In this review, we summarize the recently adopted biosensing therapy events based on Au NCs. Homogeneous fluorometric systems toward various targets, including ions, small molecules, reactive oxygen species, biomacromolecules, cancer cells, bacteria, in vitro vivo, presented by turn-off, turn-on, ratiometric tactics. The applications concluded three aspects: photodynamic therapy, photothermal as drug carrier. basic mechanisms performances these introduced. Finally, review highlights challenges future trend NC-based systems.

Language: Английский

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Synthesis of blue emitting Aloe-Gold nanoclusters and their molecular Binding, antibacterial and cytotoxicity Profiling

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 113903 - 113903

Published: Jan. 1, 2025

Language: Английский

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MoS2–Plasmonic Hybrid Platforms: Next-Generation Tools for Biological Applications

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(2), P. 111 - 111

Published: Jan. 13, 2025

The combination of molybdenum disulfide (MoS2) with plasmonic nanomaterials has opened up new possibilities in biological applications by combining MoS2’s biocompatibility and high surface area the optical sensitivity metals. These MoS2–plasmonic hybrid systems hold great promise areas such as biosensing, bioimaging, phototherapy, where their complementary properties facilitate improved detection, real-time visualization, targeted therapeutic interventions. adjustable features, combined plasmon resonance noble metals gold silver, enhance signal amplification, enabling detailed imaging selective photothermal or photodynamic therapies while minimizing effects on healthy tissue. This review explores various synthesis strategies for hybrids, including seed-mediated growth, situ deposition, heterojunction formation, which enable tailored configurations optimized specific applications. primary focus include highly sensitive biosensors detecting cancer infectious disease biomarkers, high-resolution cellular dynamics, development phototherapy methods that allow accurate tumor ablation through light-induced thermal reactive oxygen species generation. Despite promising advancements translating these platforms into clinical practice requires overcoming considerable challenges, reproducibility, toxicity, stability physiological conditions, delivery, scalable manufacturing. Addressing challenges is essential realizing potential next-generation tools diagnostics therapies.

Language: Английский

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Fluorescent nanosensors for detection of microbial toxins in food matrices: a review

Journal of Food Measurement & Characterization, Journal Year: 2024, Volume and Issue: 18(9), P. 7669 - 7699

Published: July 27, 2024

Language: Английский

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Development of novel FRET aptasensor based on the quenching ability of iron oxide-gold nanostars for the detection of aflatoxin M1

Food Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 141575 - 141575

Published: Oct. 1, 2024

Language: Английский

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A highly sensitive and reusable magnetic nano-electrochemical biosensor for the detection of the liver cancer biomarker heat shock protein 70

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159860 - 159860

Published: Jan. 1, 2025

Language: Английский

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The marvels of DNA templated gold nanoclusters: Nature's miracle materials

Next Materials, Journal Year: 2025, Volume and Issue: 8, P. 100665 - 100665

Published: April 22, 2025

Language: Английский

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Development of Optical Differential Sensing Based on Nanomaterials for Biological Analysis

Biosensors, Journal Year: 2024, Volume and Issue: 14(4), P. 170 - 170

Published: March 31, 2024

The discrimination and recognition of biological targets, such as proteins, cells, bacteria, are utmost importance in various fields research production. These include areas like medicine, clinical diagnosis, microbiology analysis. In order to efficiently cost-effectively identify a specific target from wide range possibilities, researchers have developed technique called differential sensing. Unlike traditional “lock-and-key” sensors that rely on interactions between receptors analytes, sensing makes use cross-reactive receptors. offer less specificity but can cross-react with analytes produce large amount data. Many pattern strategies been shown promising results identifying complex analytes. To create advanced sensor arrays for higher analysis efficiency larger recognizing range, nanomaterials utilized probes. possess distinct molecular affinities, optical/electrical properties, compatibility, conveniently functionalized. this review, our focus is recently reported optical utilize discriminate bioanalytes, including bacteria.

Language: Английский

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Synthesis of polyadenine-aptamer-stabilized gold nanoclusters and application to the detection of tobramycin in real samples based on their peroxidase-like activity

Food Chemistry, Journal Year: 2025, Volume and Issue: 474, P. 143194 - 143194

Published: Feb. 3, 2025

Language: Английский

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Au@Fe₃O₄ Nanoparticle-Based Colorimetric Aptasensor for Noninvasive Screening of Colorectal Cancer via Detection of Parvimonas micra

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Colorectal cancer (CRC) is a common malignancy requiring early screening to improve patient outcomes. Current methods such as colonoscopy and fecal occult blood tests have several limitations including high cost, poor specificity, invasiveness, inconvenience. Recent research has identified specific bacterial communities associated with CRC, notably Parvimonas micra (P. micra), which serves biomarker for diagnosis owing its accumulation in the malignant tissues feces of CRC patients. Herein, we employed whole-bacterium systematic evolution ligands by exponential enrichment (SELEX) method isolate high-affinity aptamers against P. using 17 selection cycles. These were subsequently bound Au@Fe3O4 nanoparticles, interaction inhibited peroxidase-like activity thereby blocking 3,3',5,5'-tetramethylbenzidine (TMB) chromogenic reaction resulting measurable reduction absorbance. This colorimetric detection strategy demonstrated linear response across range 100-108 CFU/mL limit 11 CFU/mL. Using aptasensor, assessed abundance clinical samples found significantly higher levels patients compared that healthy individuals, was consistent quantitative polymerase chain results. study therefore represents first successful identification an aptamer affinity specificity micra, leading development highly sensitive aptasensor detection. The presented approach significant potential diagnosis.

Language: Английский

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